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KHK encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. De plus, nous expédions Ketohexokinase Protéines (15) et Ketohexokinase Kits (8) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 121 products:
Human Polyclonal KHK Primary Antibody pour IHC, IHC (p) - ABIN4328612
Ishimoto, Lanaspa, Le, Garcia, Diggle, Maclean, Jackman, Asipu, Roncal-Jimenez, Kosugi, Rivard, Maruyama, Rodriguez-Iturbe, Sánchez-Lozada, Bonthron, Sautin, Johnson: Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. dans Proceedings of the National Academy of Sciences of the United States of America 2012
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Human Polyclonal KHK Primary Antibody pour ELISA, WB - ABIN561590
DAmour, Agulnick, Eliazer, Kelly, Kroon, Baetge: Efficient differentiation of human embryonic stem cells to definitive endoderm. dans Nature biotechnology 2005
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Human Polyclonal KHK Primary Antibody pour WB - ABIN391089
Springer, Lindbloom-Hawley, Schermerhorn: Tissue expression of ketohexokinase in cats. dans Research in veterinary science 2009
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Human Polyclonal KHK Primary Antibody pour ELISA, WB - ABIN561589
Levi, Cheng, Gheysens, Patel, Chan, Wang, Namavari, Gambhir: Fluorescent fructose derivatives for imaging breast cancer cells. dans Bioconjugate chemistry 2007
Cow (Bovine) Polyclonal KHK Primary Antibody pour WB - ABIN2776884
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... dans Molecular systems biology 2007
This studies provided the first evidence that fructokinase modulates vasopressin (Montrer AVP Anticorps) synthesis in the SON and secretion from the posterior pituitary into circulation.
Fructokinase knockout mice were protected from renal injury both at baseline and after high salt intake (3 wk) compared with wild-type mice. This was associated with higher levels of active (phosphorylated serine 1177) endothelial nitric oxide synthase (Montrer NOS3 Anticorps) in their kidneys.
Feedforward upregulation of fructolytic and gluconeogenic enzymes specifically requires GLUT5 (Montrer SLC2A5 Anticorps) and KHK and may proactively enhance the intestine's ability to process anticipated increases in dietary fructose concentrations.
Significant levels of blood fructose are maintained independent of dietary fructose, KHK, and GLUT5 (Montrer SLC2A5 Anticorps), probably by endogenous synthesis of fructose.
myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (Montrer HIF1A Anticorps)) activation of SF3B1 (Montrer SF3B1 Anticorps) and SF3B1 (Montrer SF3B1 Anticorps)-mediated splice switching of KHK-A to KHK-C
Fructokinase-knockout mice with delayed hydration were protected from renal injury. Thus, recurrent dehydration can induce renal injury via a fructokinase-dependent mechanism, likely from the generation of endogenous fructose via the polyol pathway.
This study demonstrates that blocking KHK and redirecting fructose metabolism to alternative pathways is an effective way to prevent visceral obesity and insulin (Montrer INS Anticorps) resistance induced by high fructose, a widespread component of Western diets.
These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.
High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.
Fructose-induced metabolic syndrome is prevented in mice lacking both fructokinase B and A but is exacerbated in mice lacking fructokinase A.
Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis were the top four botanical candidiates identified with inhibitory activity against ketohexokinase-C.
compared with normal hepatocytes, hepatocellular carcinoma (HCC (Montrer FAM126A Anticorps)) cells markedly reduce the rate of fructose metabolism and the level of reactive oxygen species, as a result of a c-Myc (Montrer MYC Anticorps)-dependent and heterogeneous nuclear ribonucleoprotein (Montrer PCBP2 Anticorps) (hnRNP (Montrer HNRNPC Anticorps)) H1- and H2-mediated switch from expression of the high-activity fructokinase (KHK)-C to the low-activity KHK-A isoform.
myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (Montrer HIF1A Anticorps)) activation of SF3B1 (Montrer SF3B2 Anticorps) and SF3B1 (Montrer SF3B2 Anticorps)-mediated splice switching of KHK-A to KHK-C
This study determined if single nucleotide polymorphisms in genes involved in fructose transport,SLC2A2 (Montrer SLC2A2 Anticorps) and SLC2A5 (Montrer SLC2A5 Anticorps) and metabolism, etohexokinase affect inter-individual variability in metabolic phenotypes.
In human hepatocytes uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose.
ketohexokinase-A serves an unknown physiologic function that remains intact in essential fructosuria.
The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma (Montrer MOK Anticorps)
Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells.
The structure of the KHK-A ternary complex revealed an active site with fructose & the ATP analogue in positions ready for phosphorylation. The effects of the pathogenic mutations Gly40Arg & Ala43Thr have been modelled in the context of the KHK structure.
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified.
, hepatic fructokinase