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Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.. De plus, nous expédions Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 Protéines (23) et Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 Kits (5) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal LRPAP1 Primary Antibody pour IF, IHC - ABIN4219250
Kounnas, Argraves, Strickland: The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330. dans The Journal of biological chemistry 1992
data also reveal that D1D2 is able to bind to a second distinct site on LRP1 (Montrer LRP1 Anticorps) to form a monovalent complex. The studies confirm the canonical model for ligand recognition by this class of receptors, which is initiated by pairs of lysine residues that dock into acidic pockets on the receptor
The clinical and biometric features we describe in this report characterize LRPAP1-related high myopia and should raise suspicion for mutations in the gene.
The inhibition caused by reagents that prevented the activation of Rap was reversed by mobilizing intracellular calcium pharmacologically, whereas that caused by acrosome reaction inhibitors that impeded Rab3 (Montrer RAB3A Anticorps)'s binding to GTP (Montrer AK3 Anticorps) was not.
The LRPAP1 I allelic variant may be considered a candidate gene for PD, predominantly in patients having the APOE (Montrer APOE Anticorps) epsilon4 allelic variant.
RAP inhibited light chain (LC)endocytosis by approximately 88% and ameliorated LC-induced cytokine responses and epithelial-to-mesenchymal transformation in human proximal tubular cells.
Mutations in LRPAP1 are associated with severe myopia in humans.
Data indicate that the region of complement-type repeats 2-5 in LDLR (Montrer LDLR Anticorps) was identified as the binding site for FVIII (Montrer F8 Anticorps) and for alpha-2-macroglobulin receptor-associated protein (RAP).
LRP1 (Montrer LRP1 Anticorps)-C/T, A2M (Montrer A2M Anticorps)-Ile/Val and APOE (Montrer APOE Anticorps)-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD.
Findings reveal that RAP is a novel Abeta (Montrer APP Anticorps)-binding protein that promotes cellular internalization of Abeta (Montrer APP Anticorps).
Adenoviral-mediated expression of human receptor-asociated protein RAP in a murine model of von Willebrand disease results in a continuous rise in FVIII (Montrer F8 Anticorps) over 6 days.
RAP deficiency attenuated atherosclerosis without influencing abdominal aortic aneurysms in hypercholesterolemic mice infused with angiotensin II.
In RAP-deficient mice megalin expression was strongly reduced and restricted to a subapical localization and NaP(i)-IIa protein distribution and abundance in the kidney was not altered.
the His-sRAP (Montrer SRA1 Anticorps)-induced acceleration of megalin (Montrer LRP2 Anticorps)-mediated endocytosis causes phosphaturia via altered subcellular distribution of NaPi-II [39-kD receptor-associated protein (RAP)]
Results suggest that receptor-associated protein (Montrer BCAP31 Anticorps) is required for the establishment of thyroglobulin (Montrer TG Anticorps) reservoirs, but its absence does not affect hormone secretion.
RAP binds to LPL (Montrer LPL Anticorps) with high affinity both in purified systems and cell extracts and RAP-deficient adipocytes secrete poorly assembled LPL (Montrer LPL Anticorps)
RAP is expressed by thyrocytes in a TSH-dependent manner, both in cultured thyroid cells and in vivo
Disruption of the RAP gene determines not only thyroid abnormalities, but also a severe defect of megalin (Montrer LRP2 Anticorps) expression and function in the kidney.
Receptor-associated protein (RAP) plays a central role in modulating Abeta (Montrer APP Anticorps) deposition in APP (Montrer APP Anticorps)/PS1 (Montrer PSEN1 Anticorps) transgenic mice
Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
alpha-2-macroglobulin receptor-associated protein
, low density lipoprotein receptor-related protein associated protein 1
, alpha-2-macroglobulin receptor-associated protein 1
, lipoprotein receptor associated protein
, low density lipoprotein receptor-related protein-associated protein 1
, low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
, receptor-associated protein
, gp330-binding 45 kDa protein
, Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin binding protein-44) (HBP-44)
, heparin-binding protein 44
, low density lipoprotein receptor related protein, associated protein 1