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MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. De plus, nous expédions MAD2L1 Anticorps (137) et MAD2L1 Protéines (8) et beaucoup plus de produits pour cette protéine.
Low MAD2L1 expression is associated with Chromophobe Renal Cell Carcinomas.
TRAP1 (Montrer TRAP1 Kits ELISA) is relevant in the control of key cell cycle regulators in tumor cells. TRAP1 (Montrer TRAP1 Kits ELISA)/TBP7 (Montrer PSMC4 Kits ELISA) quality control of CDK1 (Montrer CDK1 Kits ELISA) and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.
Thes authors show that p31 (Montrer ATP6V1E1 Kits ELISA)(comet) binding to the TRIP13 (Montrer TRIP13 Kits ELISA) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (Montrer TRIP13 Kits ELISA) "pore loops", which then unfold MAD2 in the presence of ATP.
catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (Montrer BUB3 Kits ELISA) complex assembly
in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (Montrer AURKB Kits ELISA).
Aberrant Mad2 expression was associated with cell proliferation and genetic instability, which may contribute to the carcinogenesis of PGI (Montrer BGN Kits ELISA)-DLBCL. Mad2 overexpression indicated a poor DFS (Montrer FST Kits ELISA).
interactions between Mad2 and H3K4 regulate resolution of the spindle assembly checkpoint by limiting closed Mad2 availability for Cdc20 (Montrer CDC20 Kits ELISA) inhibition.
we showed that BubR1 (Montrer BUB1B Kits ELISA) and Mad2 are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity.
Studied the folding/unfolding process of the open and closed conformers of human Mad2.
MAD1L1 (Montrer MAD1L1 Kits ELISA) Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer
Mad2 (Montrer MXI1 Kits ELISA)-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.
reduced MAD2 (Montrer MXI1 Kits ELISA) levels attenuate the apoptotic response to mis (Montrer AMH Kits ELISA)-segregating sex chromosomes and allow the formation of aneuploid sperm.
p31comet-induced cell death is mediated by interactions with Mad2 (Montrer MXI1 Kits ELISA)
study shows that Mad2 (Montrer MXI1 Kits ELISA) is a novel substrate for CCP6 (Montrer AGBL4 Kits ELISA) in megakaryocytes; Mad2 (Montrer MXI1 Kits ELISA) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis
Exacerbating chromosome missegregation in CENP-E (Montrer CENPE Kits ELISA)+/- mice by reducing levels of another mitotic checkpoint component (Montrer BUB3 Kits ELISA), Mad2 (Montrer MXI1 Kits ELISA), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.
Mad2 (Montrer MXI1 Kits ELISA) is also repressed by p53 (Montrer TP53 Kits ELISA) and its upregulation is required for chromosome instability in a p53 (Montrer TP53 Kits ELISA) mutant tumor model
Data show that Mad2 (Montrer MXI1 Kits ELISA) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (Montrer APEX1 Kits ELISA) inhibitor in vitro.
Pcid2 (Montrer PCID2 Kits ELISA) is essential for B cell survival through the regulation of MAD2 (Montrer MXI1 Kits ELISA) expression during B cell differentiation
tumours that experience transient Mad2 (Montrer MXI1 Kits ELISA) overexpression and consequent chromosome instability recur at markedly elevated rates
a functional Mad2 (Montrer MXI1 Kits ELISA)-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
, MAD2-like protein 1
, mitotic arrest deficient 2-like protein 1
, mitotic arrest deficient, yeast, homolog-like 1
, mitotic spindle assembly checkpoint protein MAD2A
, MAD2 (mitotic arrest deficient, homolog)-like 1
, MAD2-like 1
, spindle assembly checkpoint protein Mad2
, MAD2 mitotic arrest deficient-like 1
, MAD2 mitotic arrest deficient-like 1 (yeast)