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MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. De plus, nous expédions MAD2L1 Protéines (8) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 136 products:
Human Polyclonal MAD2L1 Primary Antibody pour ICC, IF - ABIN151995
Wu, Glickstein, Liu, Fujita, Li, Yang, Duvoisin, Wan: The anaphase-promoting complex coordinates initiation of lens differentiation. dans Molecular biology of the cell 2007
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Human Monoclonal MAD2L1 Primary Antibody pour IHC (p), IP - ABIN108555
Burum-Auensen, Deangelis, Schjølberg, Røislien, Andersen, Clausen: Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. dans Journal of clinical pathology 2007
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Human Monoclonal MAD2L1 Primary Antibody pour IHC (p), IP - ABIN108556
Gysin, Paquette, McMahon: Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. dans Molecular cancer research : MCR 2012
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Human Polyclonal MAD2L1 Primary Antibody pour WB - ABIN2801908
Gemma, Hosoya, Seike, Uematsu, Kurimoto, Hibino, Yoshimura, Shibuya, Kudoh, Emi: Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers. dans Lung cancer (Amsterdam, Netherlands) 2001
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Human Polyclonal MAD2L1 Primary Antibody pour ELISA, WB - ABIN268644
Li, Benezra: Identification of a human mitotic checkpoint gene: hsMAD2. dans Science (New York, N.Y.) 1996
Human Monoclonal MAD2L1 Primary Antibody pour ELISA, WB - ABIN561710
Yeh, Yeh, Chen, Juang: RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. dans The Journal of biological chemistry 2012
Human Polyclonal MAD2L1 Primary Antibody pour ICC, IF - ABIN441319
Itoh, Sugino, Ikeda, Mizuguchi, Kanno, Amin, Iemura, Yasui, Hirota, Tanaka: Nucleoporin Nup188 is required for chromosome alignment in mitosis. dans Cancer science 2013
Mad2 (Montrer MXI1 Anticorps)-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.
reduced MAD2 (Montrer MXI1 Anticorps) levels attenuate the apoptotic response to mis (Montrer AMH Anticorps)-segregating sex chromosomes and allow the formation of aneuploid sperm.
p31comet-induced cell death is mediated by interactions with Mad2 (Montrer MXI1 Anticorps)
study shows that Mad2 (Montrer MXI1 Anticorps) is a novel substrate for CCP6 (Montrer AGBL4 Anticorps) in megakaryocytes; Mad2 (Montrer MXI1 Anticorps) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis
Exacerbating chromosome missegregation in CENP-E (Montrer CENPE Anticorps)+/- mice by reducing levels of another mitotic checkpoint component (Montrer BUB3 Anticorps), Mad2 (Montrer MXI1 Anticorps), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.
Mad2 (Montrer MXI1 Anticorps) is also repressed by p53 (Montrer TP53 Anticorps) and its upregulation is required for chromosome instability in a p53 (Montrer TP53 Anticorps) mutant tumor model
Data show that Mad2 (Montrer MXI1 Anticorps) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (Montrer APEX1 Anticorps) inhibitor in vitro.
Pcid2 (Montrer PCID2 Anticorps) is essential for B cell survival through the regulation of MAD2 (Montrer MXI1 Anticorps) expression during B cell differentiation
tumours that experience transient Mad2 (Montrer MXI1 Anticorps) overexpression and consequent chromosome instability recur at markedly elevated rates
a functional Mad2 (Montrer MXI1 Anticorps)-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes
Low MAD2L1 expression is associated with Chromophobe Renal Cell Carcinomas.
TRAP1 (Montrer TRAP1 Anticorps) is relevant in the control of key cell cycle regulators in tumor cells. TRAP1 (Montrer TRAP1 Anticorps)/TBP7 (Montrer PSMC4 Anticorps) quality control of CDK1 (Montrer CDK1 Anticorps) and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.
Thes authors show that p31 (Montrer ATP6V1E1 Anticorps)(comet) binding to the TRIP13 (Montrer TRIP13 Anticorps) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (Montrer TRIP13 Anticorps) "pore loops", which then unfold MAD2 in the presence of ATP.
catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (Montrer BUB3 Anticorps) complex assembly
in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (Montrer AURKB Anticorps).
Aberrant Mad2 expression was associated with cell proliferation and genetic instability, which may contribute to the carcinogenesis of PGI (Montrer BGN Anticorps)-DLBCL. Mad2 overexpression indicated a poor DFS (Montrer FST Anticorps).
interactions between Mad2 and H3K4 regulate resolution of the spindle assembly checkpoint by limiting closed Mad2 availability for Cdc20 (Montrer CDC20 Anticorps) inhibition.
we showed that BubR1 (Montrer BUB1B Anticorps) and Mad2 are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity.
Studied the folding/unfolding process of the open and closed conformers of human Mad2.
MAD1L1 (Montrer MAD1L1 Anticorps) Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
, mitotic spindle assembly checkpoint protein MAD2A
, spindle assembly checkpoint protein Mad2
, MAD2 mitotic arrest deficient-like 1 (yeast)
, MAD2 mitotic arrest deficient-like 1
, MAD2 (mitotic arrest deficient, homolog)-like 1
, MAD2-like protein 1
, mitotic arrest deficient 2-like protein 1
, MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
, mitotic arrest deficient, yeast, homolog-like 1