anti-MDS1 and EVI1 Complex Locus (MECOM) Anticorps

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. De plus, nous expédions MDS1 and EVI1 Complex Locus Protéines (8) et MDS1 and EVI1 Complex Locus Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
MECOM 294924  
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Top anti-MDS1 and EVI1 Complex Locus Anticorps sur anticorps-enligne.fr

Showing 10 out of 118 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB Host: Rabbit Target Name: EVI1 Sample Tissue: Human 293T Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: MECOM Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1ug/ml 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human brain 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué WB WB Suggested Anti-MDS1 Antibody Titration: 1.25ug/mlELISA Titer: 1:312500Positive Control: Raji cell lysate WB Suggested Anti-MDS1  Antibody Titration: 1.25 µg/mL ELISA Titer: 1:312500  Positive Control: Raji cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
288,68 €
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of EVI1 Antibody (N-term) in CEM cell line lysates (35ug/lane). This demonstrates the EVI1 antibody detected the EVI1 protein (arrow). 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of MDS1 Antibody (Center) in mouse NIH-3T3 cell line lysates (35ug/lane). This demonstrates the MDS1 antibody detected the MDS1 protein (arrow). 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Chèvre Inconjugué ELISA, WB Western Blot: EVI1 Antibody [NBP1-68842] - Analysis of EVI1 in A549 lysate (35ug protein in RIPA buffer) using NBP1-68842 at 2ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 3 to 5 Days
388,75 €
Détails
Humain Souris Inconjugué EIA, WB 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué ELISA, IHC, WB 100 μL Connectez-vous pour afficher 13 Days
154,33 €
Détails
Humain Souris Inconjugué WB Western analysis of extracts from 293 cells using PRDM3 antibody. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails

MECOM Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Human , , , ,
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Mouse (Murine)
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Rat (Rattus)


anti-MDS1 and EVI1 Complex Locus Anticorps mieux référencés

  1. Human Polyclonal MECOM Primary Antibody pour EIA, WB - ABIN953364 : Goyama, Kurokawa: Evi-1 as a critical regulator of leukemic cells. dans International journal of hematology 2010 (PubMed)
    Show all 2 references for 953364

  2. Human Polyclonal MECOM Primary Antibody pour EIA, WB - ABIN952135 : Gómez-Benito, Conchillo, García, Vázquez, Maicas, Vicente, Cristobal, Marcotegui, García-Ortí, Bandrés, Calasanz, Alonso, Odero: EVI1 controls proliferation in acute myeloid leukaemia through modulation of miR-1-2. dans British journal of cancer 2010 (PubMed)
    Show all 2 references for 952135

  3. Human Polyclonal MECOM Primary Antibody pour ELISA, WB - ABIN4270672 : Konrad, Karger, Hackl, Schwarzinger, Herbacek, Wieser: Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. dans Journal of leukocyte biology 2009 (PubMed)

  4. Cow (Bovine) Polyclonal MECOM Primary Antibody pour WB - ABIN2787657 : Sato, Goyama, Nitta, Takeshita, Yoshimi, Nakagawa, Kawazu, Ichikawa, Kurokawa: Evi-1 promotes para-aortic splanchnopleural hematopoiesis through up-regulation of GATA-2 and repression of TGF-b signaling. dans Cancer science 2008 (PubMed)

  5. Cow (Bovine) Polyclonal MECOM Primary Antibody pour IHC, WB - ABIN2777403 : Chi, Senyuk, Chakraborty, Nucifora: EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity. dans The Journal of biological chemistry 2003 (PubMed)

  6. Human Polyclonal MECOM Primary Antibody pour WB - ABIN2780631 : Fears, Mathieu, Zeleznik-Le, Huang, Rowley, Nucifora: Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. dans Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)

Plus d’anticorps contre MDS1 and EVI1 Complex Locus partenaires d’interaction

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (Montrer NOTCH1 Anticorps) signaling

  2. Prdm3 and prdm16 (Montrer PRDM16 Anticorps) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Heterozygous germ line mutations in the RUNX1 (Montrer RUNX1 Anticorps) gene are responsible genetic events for FPD/AML (Montrer RUNX1 Anticorps).

  2. Data suggest that RUNX1 (Montrer RUNX1 Anticorps) pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1 (Montrer RUNX1 Anticorps), either mutations in RUNX1 (Montrer RUNX1 Anticorps) gene or variations in expression of RUNX1 (Montrer RUNX1 Anticorps), appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  3. The E3 ubiquitin ligase (Montrer MUL1 Anticorps) STUB1 (Montrer STUB1 Anticorps) is a negative regulator of both RUNX1 (Montrer RUNX1 Anticorps) and RUNX1 (Montrer RUNX1 Anticorps)-RUNX1T1 (Montrer RUNX1T1 Anticorps). Activation of STUB1 (Montrer STUB1 Anticorps) could be a promising therapeutic strategy for RUNX1 (Montrer RUNX1 Anticorps)-RUNX1T1 (Montrer RUNX1T1 Anticorps) leukemia.

  4. The clinical significance of ETV6 (Montrer ETV6 Anticorps)-RUNX1 (Montrer RUNX1 Anticorps).

  5. Deliver the necessary promotional drive for the progression of ETV6 (Montrer ETV6 Anticorps)-RUNX1 (Montrer RUNX1 Anticorps)+ pre-leukaemic cells.

  6. High RUNX1 (Montrer RUNX1 Anticorps) expression is associated with pancreatic cancer.

  7. these findings have identified a novel function for Runx1 (Montrer RUNX1 Anticorps) in sustaining normal mammary epithelial morphology and preventing epithelial-mesenchymal transition

  8. Leukaemogenesis by AML1 (Montrer RUNX1 Anticorps)-ETO (Montrer RUNX1T1 Anticorps) requires enhanced C/D box snoRNA/RNP (Montrer RNPC3 Anticorps) formation.

  9. The expression of EVI1 and SOX9 (Montrer SOX9 Anticorps) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (Montrer FRAP1 Anticorps) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (Montrer FRAP1 Anticorps) targeting failure

  10. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (Montrer F2 Anticorps)-activatable receptor PAR-1 (protease-activated receptor-1 (Montrer F2R Anticorps)), in Runx1 (Montrer RUNX1 Anticorps)/Cbfb (Montrer CBFB Anticorps)-deleted MLL (Montrer MLL Anticorps)-AF9 (Montrer MLLT3 Anticorps) cells. Similar to the effect of Runx1 (Montrer RUNX1 Anticorps)/Cbfb (Montrer CBFB Anticorps) deletion, PAR-1 (Montrer MARK2 Anticorps) overexpression induced CDKN1A/p21 (Montrer CDKN1A Anticorps) expression and attenuated proliferation in MLL (Montrer MLL Anticorps)-AF9 (Montrer MLLT3 Anticorps) cells

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Gata2 (Montrer GATA2 Anticorps) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  2. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  3. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (Montrer CEBPA Anticorps) from EVI1-induced suppression.

  4. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (Montrer CSF2 Anticorps), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (Montrer CSF2 Anticorps) levels.

  5. Survivin (Montrer BIRC5 Anticorps) partially regulates HSC (Montrer FUT1 Anticorps) function by modulating the Evi-1 transcription factor and its downstream targets

  6. Thrombopoietin (Montrer THPO Anticorps)/MPL (Montrer MPL Anticorps) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  7. Prdm16 (Montrer PRDM16 Anticorps) and Prdm3 control postnatal BAT (Montrer BAAT Anticorps) identity and function.

  8. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  9. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (Montrer MLL Anticorps)) fusion protein (MFP) leukemia

  10. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (Montrer CEBPB Anticorps), liver inhibitory protein (LIP), induced acute myeloid leukemia (Montrer BCL11A Anticorps) with short latencies in a mouse bone marow transplantation model.

MDS1 and EVI1 Complex Locus (MECOM) profil antigène

Profil protéine

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom) anticorps
  • MDS1 and EVI1 complex locus (MECOM) anticorps
  • MDS1 and EVI1 complex locus (LOC100343228) anticorps
  • MDS1 and EVI1 complex locus (Mecom) anticorps
  • runt-related transcription factor 1 (RUNX1) anticorps
  • AML1 anticorps
  • AML1-EVI-1 anticorps
  • AMLCR1 anticorps
  • CBFA2 anticorps
  • D630039M04Rik anticorps
  • EVI-1 anticorps
  • Evi1 anticorps
  • im:7140716 anticorps
  • Jbo anticorps
  • Mds anticorps
  • Mds1 anticorps
  • Mds1-Evi1 anticorps
  • PEBP2aB anticorps
  • Prdm3 anticorps
  • Znfpr1b1 anticorps

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPECIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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