anti-MDS1 and EVI1 Complex Locus (MECOM) Anticorps

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. De plus, nous expédions MDS1 and EVI1 Complex Locus Protéines (8) et MDS1 and EVI1 Complex Locus Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
MECOM 294924  
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Top anti-MDS1 and EVI1 Complex Locus Anticorps sur anticorps-enligne.fr

Showing 10 out of 118 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB <b>WB Suggested Anti-EVI1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Hela cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB Host: Rabbit Target Name: EVI1 Sample Tissue: Human 293T Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: MECOM Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1ug/ml 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human brain 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of EVI1 Antibody (N-term) in CEM cell line lysates (35ug/lane). This demonstrates the EVI1 antibody detected the EVI1 protein (arrow). 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Lapin Inconjugué WB <b>WB Suggested Anti-MDS1 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Raji cell lysate WB Suggested Anti-MDS1 <br /> Antibody Titration: 1.25 µg/mL ELISA Titer: 1:312500 <br /> Positive Control: Raji cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$229.00
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of MDS1 Antibody (Center) in mouse NIH-3T3 cell line lysates (35ug/lane). This demonstrates the MDS1 antibody detected the MDS1 protein (arrow). 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Chèvre Inconjugué ELISA, WB Western Blot: EVI1 Antibody [NBP1-68842] - Analysis of EVI1 in A549 lysate (35ug protein in RIPA buffer) using NBP1-68842 at 2ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 7 to 9 Days
$485.88
Détails
Humain Lapin Inconjugué WB EVI1 Antibody (N-term)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the EVI1 antibody detected the EVI1 protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Humain Souris Inconjugué EIA, WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Souris Lapin Inconjugué WB MDS1 Antibody (Center)  western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the MDS1 antibody detected the MDS1 protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails

MECOM Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Human , , , ,
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Mouse (Murine)
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Rat (Rattus)


anti-MDS1 and EVI1 Complex Locus Anticorps mieux référencés

  1. Human Polyclonal MECOM Primary Antibody pour ELISA, WB - ABIN4270672 : Konrad, Karger, Hackl, Schwarzinger, Herbacek, Wieser: Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. dans Journal of leukocyte biology 2009 (PubMed)

Plus d’anticorps contre MDS1 and EVI1 Complex Locus partenaires d’interaction

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Letter/Case Report: ETV6 (Montrer ETV6 Anticorps)/MECOM gene fusion in therapy-related acute myeloid leukemia (Montrer BCL11A Anticorps) with t(3;12) and monosomy 7.

  2. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  3. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (Montrer ETS1 Anticorps)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  4. The expression of EVI1 and SOX9 (Montrer SOX9 Anticorps) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (Montrer FRAP1 Anticorps) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (Montrer FRAP1 Anticorps) targeting failure

  5. EVI1 contributes to PCa (Montrer FLVCR1 Anticorps) progression by regulating different oncogenic functions. EVI1 regulates the PCa (Montrer FLVCR1 Anticorps) stem cell compartment responsible for disease initiation and also development of CRPC.

  6. oncogenic potential for EVI1 in modulating genomic stability

  7. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  8. EVI1 overexpression alters cellular metabolism. EVI1 promotes CKMT1 (Montrer CKMT1B Anticorps) expression by repressing the myeloid differentiation regulator RUNX1 (Montrer RUNX1 Anticorps).

  9. EVI1 transcription is directly regulated by LEF1 (Montrer LEF1 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) complex in myeloid blast crisis of chronic myeloid leukemia (Montrer BCL11A Anticorps). Loss of p53 (Montrer TP53 Anticorps) function as a key regulator for beta-catenin (Montrer CTNNB1 Anticorps)-EVI1 in myeloid blast crisis of chronic myeloid leukemia (Montrer BCL11A Anticorps).

  10. we demonstrated that miR (Montrer MLXIP Anticorps)-22 promoted monocyte/macrophage differentiation, and MECOM (EVI1) mRNA is a direct target of miR (Montrer MLXIP Anticorps)-22 and MECOM (EVI1) functions as a negative regulator in the differentiation.The miR (Montrer MLXIP Anticorps)-22-mediated MECOM degradation increased c-Jun (Montrer JUN Anticorps) but decreased GATA2 (Montrer GATA2 Anticorps) expression, which results in increased interaction between c-Jun (Montrer JUN Anticorps) and PU.1

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  2. Gata2 (Montrer GATA2 Anticorps) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  3. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  4. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (Montrer CEBPA Anticorps) from EVI1-induced suppression.

  5. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (Montrer CSF2 Anticorps), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (Montrer CSF2 Anticorps) levels.

  6. Survivin (Montrer BIRC5 Anticorps) partially regulates HSC (Montrer FUT1 Anticorps) function by modulating the Evi-1 transcription factor and its downstream targets

  7. Thrombopoietin (Montrer THPO Anticorps)/MPL (Montrer MPL Anticorps) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  8. Prdm16 (Montrer PRDM16 Anticorps) and Prdm3 control postnatal BAT (Montrer BAAT Anticorps) identity and function.

  9. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  10. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (Montrer MLL Anticorps)) fusion protein (MFP) leukemia

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (Montrer NOTCH1 Anticorps) signaling

  2. Prdm3 and prdm16 (Montrer PRDM16 Anticorps) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Xenopus laevis MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Evi-1 (Montrer RUNX1 Anticorps) is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck

MDS1 and EVI1 Complex Locus (MECOM) profil antigène

Profil protéine

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (MECOM) anticorps
  • MDS1 and EVI1 complex locus (Mecom) anticorps
  • MDS1 and EVI1 complex locus (mecom) anticorps
  • MDS1 and EVI1 complex locus L homeolog (mecom.L) anticorps
  • AML1-EVI-1 anticorps
  • D630039M04Rik anticorps
  • evi-1 anticorps
  • evi1 anticorps
  • im:7140716 anticorps
  • Jbo anticorps
  • Mds anticorps
  • Mds1 anticorps
  • Mds1-Evi1 anticorps
  • mecom anticorps
  • mecom-a anticorps
  • mecom-b anticorps
  • prdm3 anticorps
  • xEvi-1 anticorps
  • Znfpr1b1 anticorps

Protein level used designations for MECOM

AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic viral integration site 1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , MDS1 and EVI1 complex locus protein EVI1-A , ecotropic virus integration site 1 protein homolog-A , myelodysplasia syndrome 1-ectopic viral integration site 1

GENE ID SPECIES
2122 Homo sapiens
424997 Gallus gallus
532209 Bos taurus
14013 Mus musculus
497407 Danio rerio
460837 Pan troglodytes
488148 Canis lupus familiaris
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
294924 Rattus norvegicus
734157 Xenopus laevis
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