anti-MDS1 and EVI1 Complex Locus (MECOM) Anticorps

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. De plus, nous expédions MDS1 and EVI1 Complex Locus Protéines (8) et MDS1 and EVI1 Complex Locus Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
MECOM 294924  
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Top anti-MDS1 and EVI1 Complex Locus Anticorps sur anticorps-enligne.fr

Showing 10 out of 118 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB <b>WB Suggested Anti-EVI1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Hela cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB Host: Rabbit Target Name: EVI1 Sample Tissue: Human 293T Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: MECOM Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1ug/ml 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human brain 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué WB <b>WB Suggested Anti-MDS1 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Raji cell lysate WB Suggested Anti-MDS1 <br /> Antibody Titration: 1.25 µg/mL ELISA Titer: 1:312500 <br /> Positive Control: Raji cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
288,68 €
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of EVI1 Antibody (N-term) in CEM cell line lysates (35ug/lane). This demonstrates the EVI1 antibody detected the EVI1 protein (arrow). 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of MDS1 Antibody (Center) in mouse NIH-3T3 cell line lysates (35ug/lane). This demonstrates the MDS1 antibody detected the MDS1 protein (arrow). 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Chèvre Inconjugué ELISA, WB Western Blot: EVI1 Antibody [NBP1-68842] - Analysis of EVI1 in A549 lysate (35ug protein in RIPA buffer) using NBP1-68842 at 2ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 3 to 5 Days
388,75 €
Détails
Humain Souris Inconjugué EIA, WB 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué ELISA, IHC, WB 100 μL Connectez-vous pour afficher 13 Days
154,33 €
Détails
Humain Souris Inconjugué WB Western analysis of extracts from 293 cells using PRDM3 antibody. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails

MECOM Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Human , , , ,
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Mouse (Murine)
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Rat (Rattus)


anti-MDS1 and EVI1 Complex Locus Anticorps mieux référencés

  1. Human Polyclonal MECOM Primary Antibody pour ELISA, WB - ABIN4270672 : Konrad, Karger, Hackl, Schwarzinger, Herbacek, Wieser: Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. dans Journal of leukocyte biology 2009 (PubMed)

Plus d’anticorps contre MDS1 and EVI1 Complex Locus partenaires d’interaction

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (Montrer NOTCH1 Anticorps) signaling

  2. Prdm3 and prdm16 (Montrer PRDM16 Anticorps) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. discussion of the role of RUNX1 (Montrer RUNX1 Anticorps) in diseases caused by their mutations or deletions (review)

  2. Placental hematopoietic stem and progenitor cells likely arise from hematopoietic niches comprised RUNX1 (Montrer RUNX1 Anticorps)+ mesenchyme and vascular endothelium. Pregnancy complications that result in preterm birth differentially affect placental hematopoietic stem and progenitor cells localization and RUNX1 (Montrer RUNX1 Anticorps) expression

  3. deficiency alters the expression of a crucial subset of TAL1 (Montrer TAL1 Anticorps)- and NOTCH1 (Montrer NOTCH1 Anticorps)-regulated genes, including the MYB (Montrer MYB Anticorps) and MYC (Montrer MYC Anticorps) oncogenes, respectively.

  4. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (Montrer ETS1 Anticorps)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  5. Our findings strengthen previous data concerning RUNX1 (Montrer RUNX1 Anticorps) mutations in acute myeloid leukemia (Montrer BCL11A Anticorps) and support the notion that RUNX1 (Montrer RUNX1 Anticorps) mutational status should be integrated into a diagnostic workup of acute myeloid leukemia (Montrer BCL11A Anticorps).

  6. Heterozygous germ line mutations in the RUNX1 (Montrer RUNX1 Anticorps) gene are responsible genetic events for FPD/AML (Montrer RUNX1 Anticorps).

  7. Data suggest that RUNX1 (Montrer RUNX1 Anticorps) pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1 (Montrer RUNX1 Anticorps), either mutations in RUNX1 (Montrer RUNX1 Anticorps) gene or variations in expression of RUNX1 (Montrer RUNX1 Anticorps), appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  8. The E3 ubiquitin ligase (Montrer MUL1 Anticorps) STUB1 (Montrer STUB1 Anticorps) is a negative regulator of both RUNX1 (Montrer RUNX1 Anticorps) and RUNX1 (Montrer RUNX1 Anticorps)-RUNX1T1 (Montrer RUNX1T1 Anticorps). Activation of STUB1 (Montrer STUB1 Anticorps) could be a promising therapeutic strategy for RUNX1 (Montrer RUNX1 Anticorps)-RUNX1T1 (Montrer RUNX1T1 Anticorps) leukemia.

  9. The clinical significance of ETV6 (Montrer ETV6 Anticorps)-RUNX1 (Montrer RUNX1 Anticorps).

  10. Deliver the necessary promotional drive for the progression of ETV6 (Montrer ETV6 Anticorps)-RUNX1 (Montrer RUNX1 Anticorps)+ pre-leukaemic cells.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Gata2 (Montrer GATA2 Anticorps) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  2. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  3. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (Montrer CEBPA Anticorps) from EVI1-induced suppression.

  4. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (Montrer CSF2 Anticorps), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (Montrer CSF2 Anticorps) levels.

  5. Survivin (Montrer BIRC5 Anticorps) partially regulates HSC (Montrer FUT1 Anticorps) function by modulating the Evi-1 transcription factor and its downstream targets

  6. Thrombopoietin (Montrer THPO Anticorps)/MPL (Montrer MPL Anticorps) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  7. Prdm16 (Montrer PRDM16 Anticorps) and Prdm3 control postnatal BAT (Montrer BAAT Anticorps) identity and function.

  8. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  9. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (Montrer MLL Anticorps)) fusion protein (MFP) leukemia

  10. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (Montrer CEBPB Anticorps), liver inhibitory protein (LIP), induced acute myeloid leukemia (Montrer BCL11A Anticorps) with short latencies in a mouse bone marow transplantation model.

MDS1 and EVI1 Complex Locus (MECOM) profil antigène

Profil protéine

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom) anticorps
  • MDS1 and EVI1 complex locus (MECOM) anticorps
  • MDS1 and EVI1 complex locus (LOC100343228) anticorps
  • MDS1 and EVI1 complex locus (Mecom) anticorps
  • runt-related transcription factor 1 (RUNX1) anticorps
  • AML1 anticorps
  • AML1-EVI-1 anticorps
  • AMLCR1 anticorps
  • CBFA2 anticorps
  • D630039M04Rik anticorps
  • EVI-1 anticorps
  • Evi1 anticorps
  • im:7140716 anticorps
  • Jbo anticorps
  • Mds anticorps
  • Mds1 anticorps
  • Mds1-Evi1 anticorps
  • PEBP2aB anticorps
  • Prdm3 anticorps
  • Znfpr1b1 anticorps

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPECIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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