MDS1 and EVI1 Complex Locus (MECOM) Kits ELISA

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. De plus, nous expédions MDS1 and EVI1 Complex Locus Anticorps (115) et MDS1 and EVI1 Complex Locus Protéines (8) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Anti-Rat MECOM MECOM 294924  
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Plus Kits ELISA pour MDS1 and EVI1 Complex Locus partenaires d'interaction

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (Montrer NOTCH1 Kits ELISA) signaling

  2. Prdm3 and prdm16 (Montrer PRDM16 Kits ELISA) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Our findings suggest ETV6 (Montrer ETV6 Kits ELISA)-RUNX1 (Montrer RUNX1 Kits ELISA) is associated with space-time clustering of childhood leukemia (CL) and are consistent with an infection interacting with that oncogene (Montrer RAB1A Kits ELISA) in early life leading to clinical leukemia.

  2. EVI1 overexpression alters cellular metabolism. EVI1 promotes CKMT1 (Montrer CKMT1B Kits ELISA) expression by repressing the myeloid differentiation regulator RUNX1 (Montrer RUNX1 Kits ELISA).

  3. Mutation in RUNX1 (Montrer RUNX1 Kits ELISA) gene is associated with chronic myelomonocytic leukemia.

  4. RUNX1 (Montrer RUNX1 Kits ELISA)-RUNX1T1 (Montrer RUNX1T1 Kits ELISA) fusion is associated with acute myeloid leukemia (Montrer BCL11A Kits ELISA).

  5. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (Montrer RUNX1 Kits ELISA)-175) of AML1 (Montrer RUNX1 Kits ELISA)-ETO (Montrer RUNX1T1 Kits ELISA) is consistent with its contribution to the activity of full-length AML1 (Montrer RUNX1 Kits ELISA)-ETO (Montrer RUNX1T1 Kits ELISA) and is mediated through its direct association with the DNA-binding domain

  6. results provide novel insight into RUNX1 (Montrer RUNX1 Kits ELISA)-mediated perturbations of higher-order genome organization that are functionally linked with RUNX1 (Montrer RUNX1 Kits ELISA)-dependent compromised gene expression in breast cancer cells

  7. RUNX1 (Montrer RUNX1 Kits ELISA) and AXIN1 (Montrer AXIN1 Kits ELISA) proteins are strongly correlated in ER(-) tumors as well.

  8. he data suggest a central role for RUNX1 (Montrer RUNX1 Kits ELISA) as master regulator of gene expression in the U87 glioblastoma multiforme cell line and mark RUNX1 (Montrer RUNX1 Kits ELISA) as a potential target for novel future therapies for glioblastoma multiforme

  9. Study highlights the importance of interactions among lncRNA HCP5, microRNA-139, and transcription factor RUNX1 in regulating the malignant behavior of glioma cells. HCP5 down-regulated miR-139 to up-regulate RUNX1. RUNX1 promoted AEG-1 expression, which was involved in a series of oncogenic effects in glioma cells. RUNX1 also up-regulated HCP5 expression, which formed a positive feedback loop.

  10. Data suggest that RUNX1 (Montrer RUNX1 Kits ELISA) functions in stem cells regulating cell differentiation; cancer cells appear to have corrupted this function of RUNX1 (Montrer RUNX1 Kits ELISA) into promotion of oncogenesis. [REVIEW]

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (Montrer CEBPA Kits ELISA) from EVI1-induced suppression.

  2. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (Montrer CSF2 Kits ELISA), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (Montrer CSF2 Kits ELISA) levels.

  3. Survivin (Montrer BIRC5 Kits ELISA) partially regulates HSC (Montrer FUT1 Kits ELISA) function by modulating the Evi-1 transcription factor and its downstream targets

  4. Thrombopoietin (Montrer THPO Kits ELISA)/MPL (Montrer MPL Kits ELISA) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  5. Prdm16 (Montrer PRDM16 Kits ELISA) and Prdm3 control postnatal BAT (Montrer BAAT Kits ELISA) identity and function.

  6. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  7. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (Montrer MLL Kits ELISA)) fusion protein (MFP) leukemia

  8. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (Montrer CEBPB Kits ELISA), liver inhibitory protein (LIP), induced acute myeloid leukemia (Montrer BCL11A Kits ELISA) with short latencies in a mouse bone marow transplantation model.

  9. Transient Evi1 transfection inhibited TGF-beta (Montrer TGFB1 Kits ELISA)-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta (Montrer TGFB1 Kits ELISA) in MC-26 (Montrer Glycam1 Kits ELISA) mouse colon cancer cells.

  10. Evi1 is a key regulator of adipogenic competency

MDS1 and EVI1 Complex Locus (MECOM) profil antigène

Antigen Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom) anticorps
  • MDS1 and EVI1 complex locus (MECOM) anticorps
  • MDS1 and EVI1 complex locus (LOC100343228) anticorps
  • MDS1 and EVI1 complex locus (Mecom) anticorps
  • runt-related transcription factor 1 (RUNX1) anticorps
  • AML1 anticorps
  • AML1-EVI-1 anticorps
  • AMLCR1 anticorps
  • CBFA2 anticorps
  • D630039M04Rik anticorps
  • EVI-1 anticorps
  • Evi1 anticorps
  • im:7140716 anticorps
  • Jbo anticorps
  • Mds anticorps
  • Mds1 anticorps
  • Mds1-Evi1 anticorps
  • PEBP2aB anticorps
  • Prdm3 anticorps
  • Znfpr1b1 anticorps

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPECIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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