MDS1 and EVI1 Complex Locus (MECOM) Kits ELISA

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. De plus, nous expédions MDS1 and EVI1 Complex Locus Anticorps (118) et MDS1 and EVI1 Complex Locus Protéines (8) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Anti-Rat MECOM MECOM 294924  
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Plus Kits ELISA pour MDS1 and EVI1 Complex Locus partenaires d'interaction

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (Montrer NOTCH1 Kits ELISA) signaling

  2. Prdm3 and prdm16 (Montrer PRDM16 Kits ELISA) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. discussion of the role of RUNX1 (Montrer RUNX1 Kits ELISA) in diseases caused by their mutations or deletions (review)

  2. Placental hematopoietic stem and progenitor cells likely arise from hematopoietic niches comprised RUNX1 (Montrer RUNX1 Kits ELISA)+ mesenchyme and vascular endothelium. Pregnancy complications that result in preterm birth differentially affect placental hematopoietic stem and progenitor cells localization and RUNX1 (Montrer RUNX1 Kits ELISA) expression

  3. deficiency alters the expression of a crucial subset of TAL1 (Montrer TAL1 Kits ELISA)- and NOTCH1 (Montrer NOTCH1 Kits ELISA)-regulated genes, including the MYB (Montrer MYB Kits ELISA) and MYC (Montrer MYC Kits ELISA) oncogenes, respectively.

  4. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (Montrer ETS1 Kits ELISA)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  5. Our findings strengthen previous data concerning RUNX1 (Montrer RUNX1 Kits ELISA) mutations in acute myeloid leukemia (Montrer BCL11A Kits ELISA) and support the notion that RUNX1 (Montrer RUNX1 Kits ELISA) mutational status should be integrated into a diagnostic workup of acute myeloid leukemia (Montrer BCL11A Kits ELISA).

  6. Heterozygous germ line mutations in the RUNX1 (Montrer RUNX1 Kits ELISA) gene are responsible genetic events for FPD/AML (Montrer RUNX1 Kits ELISA).

  7. Data suggest that RUNX1 (Montrer RUNX1 Kits ELISA) pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1 (Montrer RUNX1 Kits ELISA), either mutations in RUNX1 (Montrer RUNX1 Kits ELISA) gene or variations in expression of RUNX1 (Montrer RUNX1 Kits ELISA), appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  8. The E3 ubiquitin ligase STUB1 (Montrer STUB1 Kits ELISA) is a negative regulator of both RUNX1 (Montrer RUNX1 Kits ELISA) and RUNX1 (Montrer RUNX1 Kits ELISA)-RUNX1T1 (Montrer RUNX1T1 Kits ELISA). Activation of STUB1 (Montrer STUB1 Kits ELISA) could be a promising therapeutic strategy for RUNX1 (Montrer RUNX1 Kits ELISA)-RUNX1T1 (Montrer RUNX1T1 Kits ELISA) leukemia.

  9. The clinical significance of ETV6 (Montrer ETV6 Kits ELISA)-RUNX1 (Montrer RUNX1 Kits ELISA).

  10. Deliver the necessary promotional drive for the progression of ETV6 (Montrer ETV6 Kits ELISA)-RUNX1 (Montrer RUNX1 Kits ELISA)+ pre-leukaemic cells.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Gata2 (Montrer GATA2 Kits ELISA) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  2. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  3. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (Montrer CEBPA Kits ELISA) from EVI1-induced suppression.

  4. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (Montrer CSF2 Kits ELISA), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (Montrer CSF2 Kits ELISA) levels.

  5. Survivin (Montrer BIRC5 Kits ELISA) partially regulates HSC (Montrer FUT1 Kits ELISA) function by modulating the Evi-1 transcription factor and its downstream targets

  6. Thrombopoietin (Montrer THPO Kits ELISA)/MPL (Montrer MPL Kits ELISA) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  7. Prdm16 (Montrer PRDM16 Kits ELISA) and Prdm3 control postnatal BAT (Montrer BAAT Kits ELISA) identity and function.

  8. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  9. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (Montrer MLL Kits ELISA)) fusion protein (MFP) leukemia

  10. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (Montrer CEBPB Kits ELISA), liver inhibitory protein (LIP), induced acute myeloid leukemia (Montrer BCL11A Kits ELISA) with short latencies in a mouse bone marow transplantation model.

MDS1 and EVI1 Complex Locus (MECOM) profil antigène

Antigen Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom) anticorps
  • MDS1 and EVI1 complex locus (MECOM) anticorps
  • MDS1 and EVI1 complex locus (LOC100343228) anticorps
  • MDS1 and EVI1 complex locus (Mecom) anticorps
  • runt-related transcription factor 1 (RUNX1) anticorps
  • AML1 anticorps
  • AML1-EVI-1 anticorps
  • AMLCR1 anticorps
  • CBFA2 anticorps
  • D630039M04Rik anticorps
  • EVI-1 anticorps
  • Evi1 anticorps
  • im:7140716 anticorps
  • Jbo anticorps
  • Mds anticorps
  • Mds1 anticorps
  • Mds1-Evi1 anticorps
  • PEBP2aB anticorps
  • Prdm3 anticorps
  • Znfpr1b1 anticorps

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPECIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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