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MDS1 and EVI1 Complex Locus (MECOM) Kits ELISA

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. De plus, nous expédions MDS1 and EVI1 Complex Locus Anticorps (118) et MDS1 and EVI1 Complex Locus Protéines (8) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Anti-Rat MECOM MECOM 294924  
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96 Tests Connectez-vous pour afficher 9 to 12 Days
788,70 €

Plus Kits ELISA pour MDS1 and EVI1 Complex Locus partenaires d'interaction

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (Montrer NOTCH1 Kits ELISA) signaling

  2. Prdm3 and prdm16 (Montrer PRDM16 Kits ELISA) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (Montrer NR4A2 Kits ELISA))early growth response (EGR)2 (Montrer EGR2 Kits ELISA) and NR4A2EGR3. Therefore, RUNX1 (Montrer RUNX1 Kits ELISA), NR4A2 (Montrer NR4A2 Kits ELISA), EGR2 (Montrer EGR2 Kits ELISA), EGR3 (Montrer EGR3 Kits ELISA) and ID4 (Montrer ID4 Kits ELISA) may be key genes associated with the pathogenesis of DS.

  2. Study shows that AML1 gene overexpression characterizes a broader range of leukemic subtypes than previously thought, including various maturation stages of B-cell acute lymphoblastic leukemia and cytogenetic types additional to those involving the AML1 gene.

  3. MECOM gene harbors both somatic frameshift mutations.

  4. the effects of various aberrations in ETV6 (Montrer ETV6 Kits ELISA) and RUNX1 (Montrer RUNX1 Kits ELISA) gene copy number on disease prognosis were evaluated in 21 pediatric patients diagnosed with B-cell ALL with/without t(12;21).

  5. The RUNX1 (Montrer RUNX1 Kits ELISA) fusion transcript encodes a truncated protein containing the Runt (Montrer RUNX1 Kits ELISA) homology domain responsible for both heterodimerization with CBFB (Montrer CBFB Kits ELISA) and DNA binding, but lacking the proline-, serine-, and threonine-rich (PST (Montrer SULT1A1 Kits ELISA)) region which is the transcription activation domain at the C terminal end

  6. novel RUNX1 (Montrer RUNX1 Kits ELISA) isoforms contribute in controlling CD56 (Montrer NCAM1 Kits ELISA) expression in acute myeloid leukemia (Montrer BCL11A Kits ELISA) cells.

  7. this paper shows that RUNX1 (Montrer RUNX1 Kits ELISA) is associated with the pathogenesis of immune thrombocytopenia possibly through regulation of Th17 cell differentiation

  8. We show that RUNX1 (Montrer RUNX1 Kits ELISA) P1 expression is associated with colon cancer free survival suggesting a role for RUNX1 (Montrer RUNX1 Kits ELISA) in aspirin's protective effect in colon cancer. Our studies reveal an effect of aspirin on RUNX1 (Montrer RUNX1 Kits ELISA) and gene expression that may additionally explain aspirin's effects in cardiovascular disease and cancer.

  9. we identified rs2249650 and rs2268276 as new AML (Montrer RUNX1 Kits ELISA) susceptibility-associated SNPs. Genome editing at rs2249650 and rs2268276 may be performed in future to uncover the effect of this potential RUNX1 (Montrer RUNX1 Kits ELISA) enhancer region.

  10. RUNX1 (Montrer RUNX1 Kits ELISA) and FKBP7 (Montrer FKBP7 Kits ELISA), involved in erythropoesis and muscle protein synthesis, respectively, are related to change in cardiorespiratory fitness in response to exercise.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (Montrer CEBPA Kits ELISA) from EVI1-induced suppression.

  2. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (Montrer CSF2 Kits ELISA), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (Montrer CSF2 Kits ELISA) levels.

  3. Survivin (Montrer BIRC5 Kits ELISA) partially regulates HSC (Montrer FUT1 Kits ELISA) function by modulating the Evi-1 transcription factor and its downstream targets

  4. Thrombopoietin (Montrer THPO Kits ELISA)/MPL (Montrer MPL Kits ELISA) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  5. Prdm16 (Montrer PRDM16 Kits ELISA) and Prdm3 control postnatal BAT (Montrer BAAT Kits ELISA) identity and function.

  6. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  7. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (Montrer MLL Kits ELISA)) fusion protein (MFP) leukemia

  8. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (Montrer CEBPB Kits ELISA), liver inhibitory protein (LIP), induced acute myeloid leukemia (Montrer BCL11A Kits ELISA) with short latencies in a mouse bone marow transplantation model.

  9. Transient Evi1 transfection inhibited TGF-beta (Montrer TGFB1 Kits ELISA)-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta (Montrer TGFB1 Kits ELISA) in MC-26 (Montrer Glycam1 Kits ELISA) mouse colon cancer cells.

  10. Evi1 is a key regulator of adipogenic competency

MDS1 and EVI1 Complex Locus (MECOM) profil antigène

Antigen Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom) anticorps
  • MDS1 and EVI1 complex locus (MECOM) anticorps
  • MDS1 and EVI1 complex locus (LOC100343228) anticorps
  • MDS1 and EVI1 complex locus (Mecom) anticorps
  • runt-related transcription factor 1 (RUNX1) anticorps
  • AML1 anticorps
  • AML1-EVI-1 anticorps
  • AMLCR1 anticorps
  • CBFA2 anticorps
  • D630039M04Rik anticorps
  • EVI-1 anticorps
  • Evi1 anticorps
  • im:7140716 anticorps
  • Jbo anticorps
  • Mds anticorps
  • Mds1 anticorps
  • Mds1-Evi1 anticorps
  • PEBP2aB anticorps
  • Prdm3 anticorps
  • Znfpr1b1 anticorps

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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