Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Kits ELISA

The protein encoded by MKL1 interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. De plus, nous expédions MKL1 Anticorps (77) et et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Humain MKL1 MKL1 57591 Q969V6
Anti-Rat MKL1 MKL1 315151  
Anti-Souris MKL1 MKL1 223701 Q8K4J6
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Plus Kits ELISA pour MKL1 partenaires d'interaction

Human Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. Data suggest 2 major isoforms of profilin (Pfn1 and Pfn2) are co-regulated by a common mechanism involving the action of MKL1 [megakaryoblastic leukemia (translocation) 1 protein] that is independent of its SRF- (serum-response factor)-related activity; cellular externalization of Pfn1, rather than transcription, is affected by the perturbations of MKL1; MKL1 can influence cell migration by modulating Pfn1 expression.

  2. RBM15-MKL1 fusion is associated with acute megakaryoblastic leukemia in non-Down syndrome.

  3. The authors show MRTF family proteins bind YAP (Montrer YAP1 Kits ELISA) via a conserved PPXY motif that interacts with the YAP (Montrer YAP1 Kits ELISA) WW domain (Montrer DRP2 Kits ELISA). This interaction allows MRTF to recruit NcoA3 (Montrer NCOA3 Kits ELISA) to the TEAD-YAP (Montrer YAP1 Kits ELISA) transcriptional complex and potentiate its transcriptional activity.

  4. The MKL1 promotes ovarian cancer cell migration and invasion by epigenetically activating MMP2 (Montrer MMP2 Kits ELISA) transcription.

  5. Data suggest an interplay between megakaryocytic leukemia 1 (MKL1) and ASH2 protein to promote tumor necrosis factor alpha (TNF-alpha (Montrer TNF Kits ELISA)) induced proinflammatory transcription in macrophages.

  6. The results suggest that integrin-adhesion-induced MRTF-A-SRF activation and ISG15 (Montrer ISG15 Kits ELISA) expression constitute a newly discovered signaling circuit that promotes cell migration and invasion.

  7. Study showed that MRTF-A and MRTF-B were upregulated in pancreatic cancer tissues supporting the hypothesis that both of them are oncogenes in pancreatic cancer.

  8. FLNA (Montrer FLNA Kits ELISA) functions as a positive cellular transducer linking actin polymerization to MKL1-SRF activity, counteracting the known repressive complex of MKL1 and monomeric G-actin (Montrer ACTB Kits ELISA).

  9. Redox-sensitive regulation of MRTF-A phosphorylation via palladin (Montrer PALLD Kits ELISA) in vascular smooth muscle cell differentiation marker gene expression.

  10. Identification of SAP (Montrer APCS Kits ELISA)-dependent Mkl1 signaling as a previously unrecognized mediator of aggressive progression of mammary tumors locally relapsing after radiotherapy.

Cow (Bovine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. beta-catenin (Montrer CTNNB1 Kits ELISA) controls myocardin (Montrer MYOCD Kits ELISA)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes.

Mouse (Murine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. knockdown of MKL1 induces a significant increase in the transcriptional activity of PPARgamma (Montrer PPARG Kits ELISA) target genes and MKL1 interacts with PPARg (Montrer PPARG Kits ELISA), suggesting that SRF and MKL1 independently inhibit brown adipogenesis and that MKL1 exerts its effect mainly by modulating PPARgamma (Montrer PPARG Kits ELISA) activity

  2. further found that hypericin ameliorates inflammatory response by suppressing MKL1, which is the essential cofactor of p65 (Montrer NFkBP65 Kits ELISA) during the transcription process. In an Abeta (Montrer APP Kits ELISA) injection AD mouse model, animals orally administrated hypericin (50 mg/kg) for seven days significantly decreased pro-inflammatory cytokines expression and NO production in hippocampus, meanwhile, hypericin improved oAbeta42-induced learning and memory...

  3. Study demonstrates that WH2 domains activate MRTF-A and contribute to target gene regulation by a competitive mechanism, independently of their role in actin filament formation.

  4. The transcriptional co-activator MRTF-A was activated by sphingosine-1-phosphate as assessed by its nuclear accumulation and induction of a RhoA (Montrer RHOA Kits ELISA)/MRTF-A luciferase reporter.

  5. MRTF-A regulates liver fibrosis by epigenetically tuning the TGF-beta (Montrer TGFB1 Kits ELISA) signaling pathway in HSCs

  6. Exploration of the molecular causes of enhanced cardiac hypertrophy revealed significant activation of beta-catenin/GSK-3beta signaling, whereas MAPK and MKL1/serum-response factor pathways were inhibited.

  7. MRTF-A is a critical for epithelial to mesenchymal transition and can be stereoselectively inhibited by CCG-1423.

  8. MKL1 plays a significant role in mediating the fibrotic response to bleomycin injury. Loss of MKL1 attenuated early neutrophil influx, as well as myofibroblast-mediated remodeling.

  9. MRTF-A/B depletion results in an increase in the cell surface expression of ICAM-1 (Montrer ICAM1 Kits ELISA) and interactions between HAoECs and leukocytes

  10. knockdown of MRTF-A synthesis abolishes the systemic sclerosis myofibroblast enhanced basal contractility and synthesis of type I collagen and inhibits the matricellular profibrotic protein, connective tissue growth factor (CCN2/CTGF (Montrer CTGF Kits ELISA)

MKL1 profil antigène

Antigen Summary

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

Gene names and symbols associated with MKL1

  • megakaryoblastic leukemia 1 protein (MKL1) anticorps
  • megakaryoblastic leukemia 1 protein (LOC100358994) anticorps
  • megakaryoblastic leukemia 1 protein (mkl1) anticorps
  • megakaryoblastic leukemia (translocation) 1 (MKL1) anticorps
  • megakaryoblastic leukemia (translocation) 1 (Mkl1) anticorps
  • megakaryoblastic leukemia (translocation) 1 (mkl1) anticorps
  • MKL (megakaryoblastic leukemia)/myocardin-like 1 (Mkl1) anticorps
  • AI852829 anticorps
  • AMKL anticorps
  • AW743281 anticorps
  • AW821984 anticorps
  • Bsac anticorps
  • Mal anticorps
  • MKL1 anticorps
  • Mrtf-A anticorps
  • mrtfa anticorps

Protein level used designations for MKL1

megakaryoblastic leukemia 1 protein , MKL/myocardin-like protein 1 , RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein , basic, SAP and coiled-coil domain , megakaryocytic acute leukemia protein , myocardin-related transcription factor A , xMRTF-A , basic SAP and coiled-coil domains , basic SAP coiled-coil transcription activator , megakaryoblastic leukemia (translocation) 1 homolog , megakaryoblastic leukemia 1 protein homolog

GENE ID SPECIES
745765 Pan troglodytes
100358994 Oryctolagus cuniculus
100510767 Anolis carolinensis
418005 Gallus gallus
57591 Homo sapiens
509011 Bos taurus
315151 Rattus norvegicus
398403 Xenopus laevis
223701 Mus musculus
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