Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Kits ELISA

The protein encoded by MKL1 interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. De plus, nous expédions MKL1 Anticorps (81) et et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Humain MKL1 MKL1 57591 Q969V6
Anti-Rat MKL1 MKL1 315151  
Anti-Souris MKL1 MKL1 223701 Q8K4J6
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Plus Kits ELISA pour MKL1 partenaires d'interaction

Human Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. Herein, we propose a new ILK (Montrer ILK Kits ELISA)-MMP9 (Montrer MMP9 Kits ELISA)-MRTF axis that appears to be critical for endothelial-mesenchymal transition differentiation of endothelial to cancer-associated fibroblasts -like cells. Thus, it might be an attractive target for cancer treatment

  2. CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.

  3. HOTAIR is regulated by the RhoC-MRTF-A-SRF signaling pathway in breast cancer cells.

  4. TNF-alpha (Montrer TNF Kits ELISA) and LPS (Montrer IRF6 Kits ELISA) promoted the interaction between MKL1 and PCAF (Montrer KAT2B Kits ELISA).

  5. MRTF-A-miR (Montrer MLXIP Kits ELISA)-206-WDR1 (Montrer WDR1 Kits ELISA) form feedback loop to regulate breast cancer cell migration.

  6. miR (Montrer MLXIP Kits ELISA)-93-5p regulates myocardin-like (Montrer MYOCD Kits ELISA) 1 and STAT3 (Montrer STAT3 Kits ELISA) to affect epithelial-mesenchymal transition controlling breast cancer cell migration

  7. results highlight the critical role of the actin-regulated MRTF transcriptional pathway for bleb-associated invasive motility, such as during entosis.

  8. transcriptional co-activator MRTF-A and actin polymerization regulated a subset of miRNAs in vascular smooth muscle. Identification of novel miRNAs regulated by actin/MRTF-A may provide further insight into the mechanisms underlying vascular disease states, such as aortic aneurysm, as well as novel ideas regarding therapeutic strategies

  9. Data suggest 2 major isoforms of profilin (Pfn1 and Pfn2) are co-regulated by a common mechanism involving the action of MKL1 [megakaryoblastic leukemia (translocation) 1 protein] that is independent of its SRF- (serum-response factor)-related activity; cellular externalization of Pfn1, rather than transcription, is affected by the perturbations of MKL1; MKL1 can influence cell migration by modulating Pfn1 expression.

  10. RBM15-MKL1 fusion is associated with acute megakaryoblastic leukemia in non-Down syndrome.

Cow (Bovine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. beta-catenin (Montrer CTNNB1 Kits ELISA) controls myocardin (Montrer MYOCD Kits ELISA)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes.

Mouse (Murine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. Here, the authors show that Rho-dependent MRTF phosphorylation reflects its nuclear accumulation and dissociation from G-actin (Montrer ACTB Kits ELISA), and identify multiple sites for MRTF phosphorylation, which contribute to transcriptional activation.

  2. BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.

  3. knockdown of MKL1 induces a significant increase in the transcriptional activity of PPARgamma (Montrer PPARG Kits ELISA) target genes and MKL1 interacts with PPARg (Montrer PPARG Kits ELISA), suggesting that SRF and MKL1 independently inhibit brown adipogenesis and that MKL1 exerts its effect mainly by modulating PPARgamma (Montrer PPARG Kits ELISA) activity

  4. further found that hypericin ameliorates inflammatory response by suppressing MKL1, which is the essential cofactor of p65 (Montrer NFkBP65 Kits ELISA) during the transcription process. In an Abeta (Montrer APP Kits ELISA) injection AD mouse model, animals orally administrated hypericin (50 mg/kg) for seven days significantly decreased pro-inflammatory cytokines expression and NO production in hippocampus, meanwhile, hypericin improved oAbeta42-induced learning and memory...

  5. Study demonstrates that WH2 domains activate MRTF-A and contribute to target gene regulation by a competitive mechanism, independently of their role in actin filament formation.

  6. The transcriptional co-activator MRTF-A was activated by sphingosine-1-phosphate as assessed by its nuclear accumulation and induction of a RhoA (Montrer RHOA Kits ELISA)/MRTF-A luciferase reporter.

  7. MRTF-A regulates liver fibrosis by epigenetically tuning the TGF-beta (Montrer TGFB1 Kits ELISA) signaling pathway in HSCs

  8. Exploration of the molecular causes of enhanced cardiac hypertrophy revealed significant activation of beta-catenin/GSK-3beta signaling, whereas MAPK and MKL1/serum-response factor pathways were inhibited.

  9. MRTF-A is a critical for epithelial to mesenchymal transition and can be stereoselectively inhibited by CCG-1423.

  10. MKL1 plays a significant role in mediating the fibrotic response to bleomycin injury. Loss of MKL1 attenuated early neutrophil influx, as well as myofibroblast-mediated remodeling.

MKL1 profil antigène

Antigen Summary

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

Gene names and symbols associated with MKL1

  • megakaryoblastic leukemia (translocation) 1 (MKL1) anticorps
  • megakaryoblastic leukemia 1 protein (mkl1) anticorps
  • megakaryoblastic leukemia (translocation) 1 (Mkl1) anticorps
  • megakaryoblastic leukemia (translocation) 1 S homeolog (mkl1.S) anticorps
  • MKL (megakaryoblastic leukemia)/myocardin-like 1 (Mkl1) anticorps
  • AI852829 anticorps
  • AMKL anticorps
  • AW743281 anticorps
  • AW821984 anticorps
  • Bsac anticorps
  • Mal anticorps
  • MKL1 anticorps
  • Mrtf-A anticorps
  • mrtfa anticorps

Protein level used designations for MKL1

megakaryoblastic leukemia 1 protein , MKL/myocardin-like protein 1 , RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein , basic, SAP and coiled-coil domain , megakaryocytic acute leukemia protein , myocardin-related transcription factor A , xMRTF-A , basic SAP and coiled-coil domains , basic SAP coiled-coil transcription activator , megakaryoblastic leukemia (translocation) 1 homolog , megakaryoblastic leukemia 1 protein homolog

745765 Pan troglodytes
100358994 Oryctolagus cuniculus
100510767 Anolis carolinensis
418005 Gallus gallus
57591 Homo sapiens
509011 Bos taurus
315151 Rattus norvegicus
398403 Xenopus laevis
223701 Mus musculus
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