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Mesp2 encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. De plus, nous expédions Mesp2 Protéines (2) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal Mesp2 Primary Antibody pour ELISA, WB - ABIN1098148
Qiu, Zhou, Jiang, Ji, Ding, Lv, Liu, Tang, Cheng, Qiu: Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis. dans Studies in health technology and informatics 2012
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Mouse (Murine) Polyclonal Mesp2 Primary Antibody pour WB - ABIN2779870
Morimoto, Takahashi, Endo, Saga: The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. dans Nature 2005
Show all 2 Pubmed References
Studies indicate that mesodermal posterior 1 (Mesp1 (Montrer MESP1 Anticorps)) and mesodermal posterior 2 (Mesp2) double-knockout embryos exhibited defective development of the embryonic mesoderm.
conclusion was supported by analyses of Mesp2 KO and Ripply1/2 double KO embryos lacking rostral and caudal (Montrer CAD Anticorps) properties, respectively
current observations of the spatiotemporal disorder of vertebral organogenesis in the Mesp2-null mice provide further insight into the pathogenesis of SCDO and STDO, and the physiological development of the axial skeleton
Data demonstrate that Mesp2 is a novel component involved in the suppression of Notch (Montrer NOTCH1 Anticorps) target genes.
Data propose a novel function of Notch (Montrer NOTCH1 Anticorps) signaling, in which a progressive oscillating wave of Notch (Montrer NOTCH1 Anticorps) activity is translated into the rostral-caudal (Montrer CAD Anticorps) polarity of a somite by regulating Mesp2 expression in the anterior presomitic mesoderm.
A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice.
Data describe the genetic interactions between Dll1 (Montrer DLL1 Anticorps), Dll3 (Montrer DLL3 Anticorps), Mesp2 and Psen1 (Montrer PSEN1 Anticorps), and the roles of Dll1 (Montrer DLL1 Anticorps)- and Dll3 (Montrer DLL3 Anticorps)-Notch (Montrer NOTCH1 Anticorps) pathways, with or without Psen1 (Montrer PSEN1 Anticorps), in rostrocaudal patterning.
Mesp2 is responsible for the rostro-caudal (Montrer CAD Anticorps) patterning process itself in the anterior presomitic mesoderm, via cellular interaction.
developmental protein "wavefront" is generated by suppression of Notch (Montrer NOTCH1 Anticorps) activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe (Montrer LFNG Anticorps) gene (Lfng (Montrer LFNG Anticorps))
Tbx6 (Montrer TBX6 Anticorps) directly binds to the Mesp2 gene upstream region and mediates Notch (Montrer NOTCH1 Anticorps) signaling, and subsequent Mesp2 transcription, in the anterior presomitic mesoderm.
MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.
Mutated MESP2 causes spondylocostal dysostosis
Mesp1 (Montrer MESP1 Anticorps) is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo.
findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).
mesoderm posterior 2
, mesoderm posterior protein 2
, class C basic helix-loop-helix protein 6