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Mesp2 encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. De plus, nous expédions Mesp2 Anticorps (35) et Mesp2 Protéines (2) et beaucoup plus de produits pour cette protéine.
Studies indicate that mesodermal posterior 1 (Mesp1) and mesodermal posterior 2 (Mesp2) double-knockout embryos exhibited defective development of the embryonic mesoderm.
conclusion was supported by analyses of Mesp2 KO and Ripply1 (Montrer RIPPLY1 Kits ELISA)/2 double KO embryos lacking rostral and caudal (Montrer CAD Kits ELISA) properties, respectively
current observations of the spatiotemporal disorder of vertebral organogenesis in the Mesp2-null mice provide further insight into the pathogenesis of SCDO and STDO, and the physiological development of the axial skeleton
Data demonstrate that Mesp2 is a novel component involved in the suppression of Notch (Montrer NOTCH1 Kits ELISA) target genes.
Data propose a novel function of Notch (Montrer NOTCH1 Kits ELISA) signaling, in which a progressive oscillating wave of Notch (Montrer NOTCH1 Kits ELISA) activity is translated into the rostral-caudal (Montrer CAD Kits ELISA) polarity of a somite by regulating Mesp2 expression in the anterior presomitic mesoderm.
A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice.
Data describe the genetic interactions between Dll1 (Montrer DLL1 Kits ELISA), Dll3 (Montrer DLL3 Kits ELISA), Mesp2 and Psen1 (Montrer PSEN1 Kits ELISA), and the roles of Dll1 (Montrer DLL1 Kits ELISA)- and Dll3 (Montrer DLL3 Kits ELISA)-Notch (Montrer NOTCH1 Kits ELISA) pathways, with or without Psen1 (Montrer PSEN1 Kits ELISA), in rostrocaudal patterning.
Mesp2 is responsible for the rostro-caudal (Montrer CAD Kits ELISA) patterning process itself in the anterior presomitic mesoderm, via cellular interaction.
developmental protein "wavefront" is generated by suppression of Notch (Montrer NOTCH1 Kits ELISA) activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe (Montrer LFNG Kits ELISA) gene (Lfng (Montrer LFNG Kits ELISA))
Tbx6 (Montrer TBX6 Kits ELISA) directly binds to the Mesp2 gene upstream region and mediates Notch (Montrer NOTCH1 Kits ELISA) signaling, and subsequent Mesp2 transcription, in the anterior presomitic mesoderm.
MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.
Mutated MESP2 causes spondylocostal dysostosis
Mesp1 is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo.
findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).
mesoderm posterior 2
, mesoderm posterior protein 2
, class C basic helix-loop-helix protein 6