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MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. De plus, nous expédions Metastasis Associated in Colon Cancer 1 Kits (7) et Metastasis Associated in Colon Cancer 1 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal MACC1 Primary Antibody pour EIA, IHC (p) - ABIN500214
Boardman: Overexpression of MACC1 leads to downstream activation of HGF/MET and potentiates metastasis and recurrence of colorectal cancer. dans Genome medicine 2009
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Human Polyclonal MACC1 Primary Antibody pour IF (p), IHC (p) - ABIN706526
Sun, Li, Dai, Tan, Zhao, Li, Wang: Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells. dans Molecular medicine reports 2015
the expression levels of MACC1 were significantly correlated with the biological processes underlying glioma cell proliferation, invasion and metastasis.
In renal cell carcinoma (Montrer MOK Anticorps), positive MACC1 expression was found to significantly correlate with distant metastasis and TNM (Montrer ODZ1 Anticorps) stage. patients with higher MACC1 expression had a significantly lower disease-free rate
conclusion, high MACC1 expression may serve as a prognostic biomarker to guide individualized management in clinical practice for digestive system neoplasms.
MACC1 promotes vasculogenic mimicry in gastric cancer by regulating the HGF/c-Met-TWIST1 (Montrer TWIST1 Anticorps)/2 signaling pathway.
MACC1 expression predicts survival outcome in colorectal cancer patients.
These results suggested that MACC1 leads to a poor prognosis in HCC (Montrer FAM126A Anticorps), partly by promoting proliferation via enhancement in glucose metabolism by HK2 (Montrer HK2 Anticorps).
our findings provide some novel insights into the role of MACC1 in breast cancer, indicating that it plays different roles in breast and several other cancers.
MACC1 overexpression predicted worse prognosis after liver resection, which was attributed to the repression of HCC (Montrer FAM126A Anticorps) cell apoptosis via a molecular mechanism in which MACC1 accelerated the activation of the HGF/c-MET/PI3K (Montrer PIK3CA Anticorps)/AKT (Montrer AKT1 Anticorps) pathway
MACC1 expression might be closely related to carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma.
Silencing of MACC1 was found to enhance the apoptosis.
Data suggest a critical role for MACC1 in lymphatic dissemination of GC, providing evidence that MACC1 upregulated VEGF-C/VEGF-D secretion to promote lymphangiogenesis via c-Met signaling.
HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer
MACC1 has a role in colorectal cancer and can be used for imaging in xenografts
MACC1 will be useful for the identification of poor prognosis subjects with colorectal cancer and is a promising new target for intervention in metastasis formation.
MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009
SH3 domain-containing protein 7a5
, metastasis-associated in colon cancer protein 1
, putative binding protein 7a5