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MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. De plus, nous expédions MACC1 Kits (9) et MACC1 Protéines (4) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 39 products:
Human Polyclonal MACC1 Primary Antibody pour EIA, IHC (p) - ABIN500214
Boardman: Overexpression of MACC1 leads to downstream activation of HGF/MET and potentiates metastasis and recurrence of colorectal cancer. dans Genome medicine 2009
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Human Polyclonal MACC1 Primary Antibody pour IF (p), IHC (p) - ABIN706526
Sun, Li, Dai, Tan, Zhao, Li, Wang: Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells. dans Molecular medicine reports 2015
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Human Polyclonal MACC1 Primary Antibody pour IHC, IHC (p) - ABIN4332277
Ge, Meng, Zhou, Zhang, Ding: Positive MACC1 expression correlates with invasive behaviors and postoperative liver metastasis in colon cancer. dans International journal of clinical and experimental medicine 2015
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Human Polyclonal MACC1 Primary Antibody pour IHC, IHC (p) - ABIN4332275
Hagemann, Fuchs, Monoranu, Herrmann, Smith, Hohmann, Grabiec, Kessler, Dehghani, Löhr, Ernestus, Vince, Stein: Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis. dans Neuro-oncology 2013
MACC1 gene (metastasis-associated in colon cancer 1) is upregulated in cancer stem cells both resistant and sensitive to chemotherapy
MACC1 overexpression is associated with gastric cancer.
High MACC1 expression is associated with colorectal cancer.
Downregulation of MACC1 upregulates E-cadherin (Montrer CDH1 Anticorps), N-cadherin (Montrer CDH2 Anticorps) and Vimentin (Montrer VIM Anticorps) in melanoma cell lines.
MACC1 is essential for acetylcholine-induced gastric cancer cell invasion/migration and epithelial-mesenchymal transition
Study demonstrated that suppression of MACC1 improves the chemosensitivity of cisplatin in epithelial ovarian cancer cells probably through regulation of the ERK1/2 (Montrer MAPK1/3 Anticorps) signaling pathway and P-gp (Montrer ABCB4 Anticorps) and its downstream apoptotic proteins.
MACC1 was a specific target gene of miR (Montrer MLXIP Anticorps)-338-3p, which regulates malignant biological behaviors of glioma cells partly through directly silencing MACC1 expression.
This study suggests that MACC1 is an independent prognostic factor in gastric adenocarcinoma and that the prognostic impact of MACC1 may be associated with MACC1 partners other than MET.
Metastasis-associated in colon cancer-1 may have an important role in tumour development in adenoid cystic carcinoma. Metastasis-associated in colon cancer-1 is a potential biomarker for adenoid cystic carcinoma.
downregulation of MACC1 expression could enhance cisplatin sensitivity and decrease drug resistance in SKOV- 3/DDP (Montrer TIMM8A Anticorps) cells.
Data suggest a critical role for MACC1 in lymphatic dissemination of GC, providing evidence that MACC1 upregulated VEGF-C/VEGF-D secretion to promote lymphangiogenesis via c-Met signaling.
HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer
MACC1 has a role in colorectal cancer and can be used for imaging in xenografts
MACC1 will be useful for the identification of poor prognosis subjects with colorectal cancer and is a promising new target for intervention in metastasis formation.
MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009
SH3 domain-containing protein 7a5
, metastasis-associated in colon cancer protein 1
, putative binding protein 7a5