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This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. De plus, nous expédions Mitochondrial Fission Factor Anticorps (55) et Mitochondrial Fission Factor Protéines (7) et beaucoup plus de produits pour cette protéine.
We suggest that, even if laboratory findings are not indicative of mitochondrial or peroxisomal dysfunction, the co-occurrence of optic and/or peripheral neuropathy with seizures warrants genetic testing for MFF mutations
membrane-anchored Mff differentially regulates various Drp1 (Montrer CRMP1 Kits ELISA) isoforms.
Data show that expression of MFF protein, miR-593-5p and BRCA1 protein correlates with cisplatin sensitivity and survival of tongue squamous cell carcinoma (TSCC).
loss of Mff results in failure of Parkin (Montrer PARK2 Kits ELISA) translocation and final clearance of damaged mitochondria
Mitochondrial fission factor (MFF) mRNA is a direct target of miR (Montrer MLXIP Kits ELISA)-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region.
MiD49 (Montrer SMCR7 Kits ELISA) and MiD51 (Montrer SMCR7L Kits ELISA) can act independently of Mff and Fis1 (Montrer FIS1 Kits ELISA) in Drp1 (Montrer CRMP1 Kits ELISA) recruitment and suggest that they provide specificity to the division of mitochondria.
TRAP1 (Montrer TRAP1 Kits ELISA) controls mitochondrial fusion/fission balance through Drp1 (Montrer CRMP1 Kits ELISA) and Mff expression.
PEX11 proteins attract both Mff and human Fis1 (hFis1 (Montrer FIS1 Kits ELISA)) to their site of action.
MFF over-expression results in extensive mitochondrial fragmentation, driving mitochondrial dysfunction. MFF fibroblasts undergo oxidative stress, with increased ROS (Montrer ROS1 Kits ELISA) production, and the onset of autophagy and mitophagy.
MFF gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.
MiD51 (Montrer SMCR7L Kits ELISA) can suppress Mff-dependent enhancement of Drp1 (Montrer CRMP1 Kits ELISA) GTPase (Montrer RACGAP1 Kits ELISA) activity.
Mff cannot bind to assembly-deficient mutants of Drp1 (Montrer CRMP1 Kits ELISA), suggesting that Mff selectively interacts with higher-order complexes of Drp1 (Montrer CRMP1 Kits ELISA).
These findings provide a mechanism wherein the multimeric states of both Mff and Drp1 (Montrer CRMP1 Kits ELISA) regulate their collaborative interaction.
Ablating Mfn1 (Montrer MFN1 Kits ELISA) eliminates the cardiac-related lethality of Mff knockout mice.
Mitochondrial fission factor has been identified as a new AMPK (Montrer PRKAA1 Kits ELISA) substrate.
This study reveals a novel model of mitochondrial fission regulation, which is composed of miR (Montrer MLXIP Kits ELISA)-761 and mitochondrial fission factor
immunofluorescence analysis of Drp1 (Montrer CRMP1 Kits ELISA) suggests that Fis1 (Montrer FIS1 Kits ELISA) and Mff are important for the number and size of Drp1 (Montrer CRMP1 Kits ELISA) puncta on mitochondria.
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants.
mitochondrial fission factor homolog B
, mitochondrial fission factor homolog A
, mitochondrial fission factor
, Uncharacterized protein C2orf33 homolog