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MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. De plus, nous expédions MAPK8IP1 Anticorps (75) et MAPK8IP1 Protéines (4) et beaucoup plus de produits pour cette protéine.
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It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK (Montrer MAPK8 Kits ELISA) signaling may contribute to amyloid-independent mechanisms of AD pathogenesis.
Enhanced fast-velocity and efficient high-frequency APP (Montrer APP Kits ELISA) anterograde transport observed in neurons are mediated by novel roles of JIP1b.
a simple yet modular mechanism for JIP1 scaffold assembly in mammals
There is a collaborative relationship between JIP1 and AKT (Montrer AKT1 Kits ELISA) that is required for axon growth and can be regulated by changes in neuronal activity.
identify plenty of SH3 (POSH (Montrer SH3RF1 Kits ELISA)) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 (Montrer MAPK8 Kits ELISA) activation in CD8 (Montrer CD8A Kits ELISA)(+) T cells.
The phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP (Montrer APP Kits ELISA) transport in neurons.
Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (Montrer MAP3K11 Kits ELISA) interaction with JIP1 scaffold protein (Montrer HOMER1 Kits ELISA) in cytokine-induced pancreatic beta cell death
JIP1 forms a trimetric complex with RBP-Jk (Montrer RBPJ Kits ELISA) and Notch1 (Montrer NOTCH1 Kits ELISA)-IC, prevents physical association between Notch1 (Montrer NOTCH1 Kits ELISA)-IC and RBP-Jk (Montrer RBPJ Kits ELISA), sequesters RBP-JK (Montrer RBPJ Kits ELISA) in the cytoplasm, and suppresses the Notch1 (Montrer NOTCH1 Kits ELISA) signaling pathway.
Data suggest that JIP1-mediated JNK (Montrer MAPK8 Kits ELISA) activation plays a critical role in metabolic stress regulation of the JNK (Montrer MAPK8 Kits ELISA) signaling pathway.
JIP1b can directly modulate APP (Montrer APP Kits ELISA) metabolism by interacting with the APP (Montrer APP Kits ELISA) cytoplasmic domain, independent of its regulation of the JNK (Montrer MAPK8 Kits ELISA) signaling cascade.
All binary complexes (KLC1 (Montrer KLC1 Kits ELISA):APP (Montrer APP Kits ELISA), KLC1 (Montrer KLC1 Kits ELISA):JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 (Montrer KLC1 Kits ELISA) and JIP1 may take part in APP (Montrer APP Kits ELISA) transport in Alzheimer's disease patients.
analysis of the role of JIP1 in APP (Montrer APP Kits ELISA) transport; knockdown of JIP1 did not affect either amyloid precursor protein (Montrer APP Kits ELISA) transport or amyloid-beta peptide production
Data show that small GTPase (Montrer RACGAP1 Kits ELISA) RALA (Montrer rala Kits ELISA) regulates formation of a JIP1 (C-Jun (Montrer JUN Kits ELISA)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (Montrer MAPK8 Kits ELISA) signaling toward FOXO4 (Montrer FOXO4 Kits ELISA) (forkhead box O transcription factor) in response to reactive oxygen species (ROS (Montrer ROS1 Kits ELISA)).
In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present.
Data suggest that caspase 3 (Montrer CASP3 Kits ELISA)-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK (Montrer MAPK8 Kits ELISA) signalling during apoptotic cell death.
Data show that mechanical stress of urothelial cells activates in vivo JNK (Montrer MAPK8 Kits ELISA), as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 (Montrer GJB2 Kits ELISA) may be directly regulated by the AP-1 (Montrer FOSB Kits ELISA) complex.
results suggest that JIP (Montrer SMAD4 Kits ELISA)-1b may function as a protein linking the kinesin-I motor protein to the cargo receptor, APP (Montrer APP Kits ELISA), and that the JNK (Montrer MAPK8 Kits ELISA) signaling pathway may regulate the phosphorylation of this cargo protein through the JIP (Montrer SMAD4 Kits ELISA)-1b scaffold
JIP1 may act as an Akt1 (Montrer AKT1 Kits ELISA) scaffold, which regulates the enzymatic activity of Akt1 (Montrer AKT1 Kits ELISA) and can exert signaling effects independent of JNK (Montrer MAPK8 Kits ELISA) activity
JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
mitogen-activated protein kinase 8 interacting protein 1
, c-Jun-amino-terminal kinase-interacting protein 1-like
, C-Jun-amino-terminal kinase-interacting protein 1
, JNK MAP kinase scaffold protein 1
, JNK-interacting protein 1
, mitogen activated protein kinase 8 interacting protein 1
, mitogen-activated protein kinase 8-interacting protein 1
, protein kinase, mitogen-activated 8 interacting protein
, JIP-1-related protein
, mitogen activated protein kinase 8 interacting protein
, PRKM8 interacting protein
, islet-brain 1
, islet brain 1