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The protein encoded by MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. De plus, nous expédions Mitogen-Activated Protein Kinase 8 Interacting Protein 3 Anticorps (50) et et beaucoup plus de produits pour cette protéine.
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
The crystal structure of an N-terminally truncated form of LZII of JIP3 alone shows an unexpected antiparallel arrangement.
Results demonstrated the increased expression of JIP3 in the temporal neocortex of TLE patients and in the experimental model of epileptic seizures
JSAP1 and JLP (Montrer SPAG9 Kits ELISA) play critical roles in kinesin-1-dependent axonal transport
The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin (Montrer PPFIA1 Kits ELISA)-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions
This study demonistrated that JIP3 mediates TrkB (Montrer NTRK2 Kits ELISA) axonal anterograde transport and enhances BDNF (Montrer BDNF Kits ELISA) signaling by directly bridging TrkB (Montrer NTRK2 Kits ELISA) with kinesin-1.
Expression of constitutively active PI3K (Montrer PIK3CA Kits ELISA) stimulated translocation of Tiam1 to the membrane, increased Rac1 activity, and increased wound healing of airway epithelial cells. Increased Rac1 activity resulted in increased phosphorylation of JNK1 (Montrer MAPK8 Kits ELISA).
demonstration that JSAP1 bound ASK1 (Montrer MAP3K5 Kits ELISA) and enhanced ASK1 (Montrer MAP3K5 Kits ELISA)- and H2O2-induced JNK (Montrer MAPK8 Kits ELISA) activity
Pressure application of 160 mmHg for 3 h produced cell proliferation and activated ERK (Montrer EPHB2 Kits ELISA) and c-JUN N-terminal kinase
JIP1 (Montrer MAPK8IP1 Kits ELISA) and JIP3, have a cross-talk that leads to the regulation of the ASK1 (Montrer MAP3K5 Kits ELISA)-SEK1 (Montrer MAP2K4 Kits ELISA)-JNK (Montrer MAPK8 Kits ELISA) signal during glucose deprivation; cross-talk between JIP3 and JIP1 (Montrer MAPK8IP1 Kits ELISA) is mediated through SEK1 (Montrer MAP2K4 Kits ELISA)-JNK2 (Montrer MAPK9 Kits ELISA) and Akt1 (Montrer AKT1 Kits ELISA).
JSAP1.FAK (Montrer PTK2 Kits ELISA) complex functions cooperatively as a scaffold for the JNK (Montrer MAPK8 Kits ELISA) signaling pathway and regulator of cell migration on FN
These results establish the critical role of JIP3-dependent axonal lysosome transport in regulating amyloidogenic amyloid precursor protein (Montrer APP Kits ELISA) processing and support a model wherein Abeta (Montrer APP Kits ELISA) production is amplified by plaque-induced axonal lysosome transport defects.
Data show that c-Jun NH2-terminal kinase (JNK (Montrer MAPK8 Kits ELISA))-interacting protein-3 (JIP3) participates in the migration of cortical neurons during cortical development by mediating TrkB (Montrer NTRK2 Kits ELISA) receptor axonal anterograde transport.
JSAP1/JIP3 and JLP (Montrer SPAG9 Kits ELISA) regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration
These findings reveal that JIP3 regulation of kinesin-1 motility is critical for axon elongation and regeneration.
JSAP1 and JLP (Montrer SPAG9 Kits ELISA), which might be paralogous to each other, are critical and functionally redundant in cytokinesis and control ARF6 (Montrer ARF6 Kits ELISA) localization to the midbody by forming a tripartite complex of JSAP1/JLP (Montrer SPAG9 Kits ELISA), active ARF6 (Montrer ARF6 Kits ELISA), and kinesin-1.
JIP3 regulates neuronal axon elongation in a kinesin- and JNK (Montrer MAPK8 Kits ELISA)-dependent manner
Results suggest that JSAP1 is required for the pathfinding of the developing telencephalic commissures in the early brains.
syd activates kinesin heavy chain for transport & enhances its motility, increasing its velocity & run length. syd mutants binding KHC but not kinesin light chain are transported to axons & dendrites normally.
The results provide evidence that ARF6 (Montrer ARF6 Kits ELISA)/JIP3 signaling regulates neurite morphogenesis.
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
mitogen-activated protein kinase 8 interacting protein 3
, C-Jun-amino-terminal kinase-interacting protein 3
, JNK-interacting protein 3
, c-Jun-amino-terminal kinase-interacting protein 3-like
, C-jun-amino-terminal kinase interacting protein 3
, JNK MAP kinase scaffold protein 3
, JNK/SAPK-associated protein-1
, JNK/stress-activated protein kinase-associated protein 1
, homolog of Drosophila Sunday driver 2
, mitogen-activated protein kinase 8-interacting protein 3
, JNK/SAPK-associated protein 1
, JNK/SAPK-associated protein 1c
, JUN/SAPK-associated protein 1
, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1
, mitogen activated protein kinase 8 interacting protein 3
, sunday driver 2