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Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM, Mar 2008].. De plus, nous expédions MIXL1 Protéines (4) et et beaucoup plus de produits pour cette protéine.
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Findings support the existence of a novel MIXL1-c REL (Montrer NFkBP65 Anticorps) mediated survival axis in AML (Montrer RUNX1 Anticorps) that can be targeted by BMPR1 (Montrer BMPR1A Anticorps) inhibitors. (MIXL1- human gene, Mixl1- mouse ortholog, MIXL1- protein).
results demonstrate that Mixl1 and Flk1 (Montrer KDR Anticorps) play roles...during dimethyl sulfoxide-induced mesodermal specification in P19 (Montrer CDKN2D Anticorps) cells.
Brachyury (Montrer TBX1 Anticorps) and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity
These results demonstrate for a functional role for TGF-beta (Montrer TGFB1 Anticorps) ligands in regulation of mammalian Mixl1, identify FoxH1 (Montrer FOXH1 Anticorps) as an essential co-activator, and implicate Nodal as the embryonic regulator of Mixl1 in mesendoderm morphogenesis.
MIXL1 protein is differentially expressed in non-Hodgkin lymphoma and Hodgkin lymphoma; findings suggest that MIXL1 overexpression may play a role in driving proliferatin or blocking differentiation in lymphoma oncogenesis
Targeted insertion in human embryonic stem cells of sequences encoding green fluorescent protein (GFP) into the locus of MIXL1, a gene transiently expressed in the primitive streak during embryogenesis.
In this study, we demonstrated that forced expression of Mix-like protein 1 (encoded by Mixl1) can be used to guide contribution of mouse embryonic stem cells to endodermal organs after blastocyst injection.
Embryonic localization of Mixl1 shows its co-localized with the early hematopoietic marker, Runx1 (Montrer RUNX1 Anticorps), in the allantois and visceral yolk sac (Montrer ADCY10 Anticorps) blood islands.
At later stages, in contrast with wild-type embryos, E7.5-8.0, Mixl1 knockout (KO) KO/KO (Montrer KRT8 Anticorps) embryos lacked morphologically recognizable midline structures such as the node and notochord.
These data support the hypothesis that Mixl1 directly regulates Pdgfralpha and Flk1 (Montrer KDR Anticorps) gene expression.
results strongly suggest that Gsc (Montrer GSC Anticorps) is a direct target gene of Mixl1 during embryogenesis.
required for the morphogenesis of axial mesoderm, the heart and the gut (Montrer GUSB Anticorps) during embryogenesis
Mixl1 is required for efficient haematopoiesis and BMP4 (Montrer BMP4 Anticorps)-induced ventral mesoderm patterning in differentiating ES cells
all mice reconstituted with Mixl1-transduced bone marrow developed fatal, transplantable acute myeloid leukemia (Montrer BCL11A Anticorps) with a mean latency period of 200 days
As goosecoid (Montrer GSC Anticorps) is itself induced in a Foxh1 (Montrer FOXH1 Anticorps)-dependent manner, we propose that Foxh1 (Montrer FOXH1 Anticorps) initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation
Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005
Mix1 homeobox-like 1 (Xenopus laevis)
, Mix-like homeobox protein 1
, MIX1 homeobox-like protein 1
, homeobox protein MIXL1
, homeodomain protein MIX
, mix.1 homeobox-like protein
, CMIX homeobox
, Mix1 homeobox-like 1