Muscleblind-Like 2 (Drosophila) (MBNL2) Kits ELISA

MBNL2 is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. De plus, nous expédions MBNL2 Anticorps (31) et MBNL2 Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Souris MBNL2 MBNL2 105559 Q8C181
Anti-Humain MBNL2 MBNL2 10150 Q5VZF2
Anti-Rat MBNL2 MBNL2 680445 F2Z3T4
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Plus Kits ELISA pour MBNL2 partenaires d'interaction

Mouse (Murine) Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Depletion of Mbnl1 and/or Mbnl2 reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites

  2. Sense DMPK (Montrer DMPK Kits ELISA) RNA foci clearly co-localize with MBNL1 and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  3. depletion of Mbnl proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.

  4. consistent with a central and negative regulatory role for MBNL proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  5. This analysis identified several hundred splicing events whose regulation depended on Mbnl function in a pattern indicating functional interchangeability between Mbnl1 and Mbnl2.

  6. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  7. Conserved developmental stage- and tissue-specific alternative splicing of MBNL transcripts is an important mechanism by which MBNL activity is regulated during embryonic development.

  8. The authors propose that expanded CTG DNA repeats cause two separate effects: loss of Mbnl1 function (disrupting splicing) and loss of another function that disrupts extracellular matrix mRNA regulation, possibly mediated by Mbnl2.

  9. MBNL2 contribute to the pathogenesis of myotonic dystrophy.

Zebrafish Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. MBNL2 in splicing regulation of specific transcripts, which, when altered, contributes to the myotonic dystrophy phenotype.

Human Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Sense DMPK (Montrer DMPK Kits ELISA) RNA foci clearly co-localize with MBNL1 and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  2. both MBNL1 and MBNL2 are involved in the regulation of Tau exon 2 splicing and the mis-splicing of Tau in DM1 is due to the combined inactivation of both

  3. consistent with a central and negative regulatory role for MBNL proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  4. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  5. MBNL proteins promote opposite splicing patterns for cardiac troponin T (Montrer TNNT2 Kits ELISA) and insulin receptor (Montrer INSR Kits ELISA) alternative exons

  6. MBNL1 and MBNL2 always co-distributed. Functional differences between MBNL1 and MBNL2 have not yet been found

  7. solution structures of both tandem zinc finger (TZF) motifs, TZF12 (comprising ZF1 (Montrer PRMT1 Kits ELISA) and ZF2 (Montrer ZNF274 Kits ELISA)) and TZF34 (ZF3 and ZF4), in MBNL2

MBNL2 profil antigène

Antigen Summary

This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.

Gene names and symbols associated with MBNL2

  • muscleblind-like 2 (Mbnl2) anticorps
  • muscleblind-like 2 (Drosophila) (mbnl2) anticorps
  • muscleblind-like 2 (Drosophila) (MBNL2) anticorps
  • muscleblind-like splicing regulator 2 (MBNL2) anticorps
  • muscleblind-like splicing regulator 2 (Mbnl2) anticorps
  • 1110002M11Rik anticorps
  • AI047808 anticorps
  • AI837313 anticorps
  • AI849185 anticorps
  • AL118326 anticorps
  • MBLL anticorps
  • MBLL39 anticorps
  • mKIAA4072 anticorps
  • PRO2032 anticorps
  • R75232 anticorps
  • wu:fj89c04 anticorps

Protein level used designations for MBNL2

muscleblind-like protein 2 , fj89c04 , muscleblind-like 2 , muscleblind-like protein 1 , muscleblind-like protein-like 39

GENE ID SPECIES
105559 Mus musculus
560384 Danio rerio
418784 Gallus gallus
527679 Bos taurus
10150 Homo sapiens
612815 Canis lupus familiaris
680445 Rattus norvegicus
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