Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Kits ELISA

mouse homolog regulates pattern formation during embryogenesis [RGD, Feb 2006].. De plus, nous expédions Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Anticorps (83) et Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Protéines (4) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Humain MLLT3 MLLT3 4300 P42568
Anti-Souris MLLT3 MLLT3 70122 A2AM29
Anti-Rat MLLT3 MLLT3 114510  
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Plus Kits ELISA pour Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 partenaires d'interaction

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) interaction partners

  1. YEATS domain of AF9 directly links histone crotonylation to active transcription.

  2. Results show that human MLL (Montrer MLL Kits ELISA)-AF9 expression in mouse long-term hematopoietic stem cells causes invasive, chemoresistant acute myeloid leukemia (Montrer BCL11A Kits ELISA) that expresses genes related to epithelial-mesenchymal transition.

  3. Results show that MLL (Montrer MLL Kits ELISA)-AF9 reduces Id2 and increases E2-2 (Montrer TCF4 Kits ELISA) expression to drive and sustain leukemia stem cell potential in MLL (Montrer MLL Kits ELISA)-rearranged acute myeloid leukemia (Montrer BCL11A Kits ELISA) (AML (Montrer RUNX1 Kits ELISA)). Low expression of Id2 or of an Id2 gene signature is associated with poor prognosis in not only MLL (Montrer MLL Kits ELISA)-rearranged but also t(8;21) AML (Montrer RUNX1 Kits ELISA) patients.

  4. Exploring the mechanism how AF9 recognizes and binds H3K9ac by molecular dynamics simulations and free energy calculations.

  5. Studies identified the evolutionarily conserved Af9 YEATS domain as a novel acetyllysine-binding module and established a direct link between histone acetylation and DOT1L (Montrer DOT1L Kits ELISA)-mediated H3K79 methylation in transcription control.

  6. AF9 and its homolog ENL directly interact with AF4.

  7. Abrogation of Rac1 signaling causes DNA double-strand breaks in acute monocytic leukemia (Montrer KAT6B Kits ELISA) cells harbouring the MLL (Montrer MLL Kits ELISA)-AF9 oncogene (Montrer RAB1A Kits ELISA).

  8. Interaction with CBX8 (Montrer CBX8 Kits ELISA) precludes AF9-DOT1L (Montrer DOT1L Kits ELISA) binding.

  9. We demonstrate that leukemogenic activity of MLL (Montrer MLL Kits ELISA)-AF9 requires RUVBL2 (RuvB-like 2 (Montrer RUVBL2 Kits ELISA)), an AAA (Montrer APP Kits ELISA)+ ATPase (Montrer DNAH8 Kits ELISA) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  10. neonatal cells expressing MLL (Montrer MLL Kits ELISA)-AF9 were enriched for gene signatures associated with poor prognosis

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) interaction partners

  1. YEATS domain of AF9 directly links histone crotonylation to active transcription.

  2. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  3. Using a PDK1 (Montrer PDPK1 Kits ELISA) conditional deletion MLL (Montrer MLL Kits ELISA)-AF9 murine AML (Montrer RUNX1 Kits ELISA) model, we revealed that the deletion of PDK1 (Montrer PDPK1 Kits ELISA) prolonged the survival of AML (Montrer RUNX1 Kits ELISA) mice by inducing LSC (Montrer ARHGEF1 Kits ELISA) apoptosis

  4. define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL (Montrer MLL Kits ELISA)-mediated transformation of HPCs

  5. Af9 mediates site-selective physical and functional recruitment of Rnf2 (Montrer RNF2 Kits ELISA) to the alpha-ENaC (Montrer SCNN1A Kits ELISA) promoter to constrain basal alpha-ENaC (Montrer SCNN1A Kits ELISA) transcription in collecting duct cells.

  6. Impaired alphaENaC (Montrer SCNN1A Kits ELISA) expression due to failure to inhibit Dot1a-Af9 may play an important role in the early stages of pseudohypoaldosteronism type 1 in MR(-/-) mice.

  7. We demonstrate that leukemogenic activity of MLL (Montrer MLL Kits ELISA)-AF9 requires RUVBL2 (RuvB-like 2 (Montrer RUVBL2 Kits ELISA)), an AAA (Montrer AAAS Kits ELISA)+ ATPase (Montrer DNAH8 Kits ELISA) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  8. Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 (Montrer EDN1 Kits ELISA) transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes.

  9. It was concluded that +78/+92 of the epithelial Na+ channel alpha (Montrer SCNN1A Kits ELISA)-subunit (Montrer POLG Kits ELISA) represents the primary Af9 binding site involved in recruiting Dot1a to repress basal and aldosterone-sensitive Na+ channel alpha-subunit (Montrer POLG Kits ELISA) transcription.

  10. PRC2 supports aberrant self-renewal in a mouse model of MLL (Montrer MLL Kits ELISA)-AF9;Nras (Montrer NRAS Kits ELISA)(G12D) acute myeloid leukemia (Montrer BCL11A Kits ELISA).

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) profil antigène

Antigen Summary

mouse homolog regulates pattern formation during embryogenesis

Gene names and symbols associated with MLLT3

  • myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila) (mllt3) anticorps
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3) anticorps
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (Mllt3) anticorps
  • 2210011H10Rik anticorps
  • 2610012I03Rik anticorps
  • 3830408D16Rik anticorps
  • Af-9 anticorps
  • Af9 anticorps
  • D4Ertd321e anticorps
  • fc39c11 anticorps
  • wu:fc39c11 anticorps
  • YEATS3 anticorps
  • zgc:110210 anticorps

Protein level used designations for MLLT3

protein AF-9 , ALL1-fused gene from chromosome 9 protein , YEATS domain-containing protein 3 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog , myeloid/lymphoid or mixed-lineage leukemia, translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila) , translocated to, 3

GENE ID SPECIES
550517 Danio rerio
4300 Homo sapiens
521962 Bos taurus
70122 Mus musculus
481556 Canis lupus familiaris
114510 Rattus norvegicus
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