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NELL1 encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. De plus, nous expédions NEL-Like 1 (Chicken) Anticorps (33) et NEL-Like 1 (Chicken) Protéines (8) et beaucoup plus de produits pour cette protéine.
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Nell-1-haploinsufficient mice (Montrer WNT2 Kits ELISA)have normal s (Montrer CTNNB1 Kits ELISA)keletal development but undergo age-related osteoporosis, characterized by a reduction in osteoblast:osteoclast ratio and increased bone fragility.
These results suggest that an oligomerization-induced conformational change in the C-terminal region of NELL1 is important for the efficient mediation of cell adhesion and spreading by NELL1.
Nell-1 might play a role in ameloblast and odontoblast differentiation, secretion and mineralization of the extracellular enamel matrix, molar crown morphogenesis, as well as root formation during the entire development period.
NELL-1 protein promotes cell adhesion in ST2 cells.
The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin alpha3beta1
data suggest Nell-1 is important growth factor for regulation of osteochondral differentiation regulating both Runx2 (Montrer RUNX2 Kits ELISA) and Sox9 (Montrer SOX9 Kits ELISA) expression in calvarium. Nell-1 is required for normal craniofacial membranous and endochondral skeletal development.
These studies suggest that Nell-1 is a potent anti-adipogenic agent. Moreover, Nell-1 signaling may inhibit adipogenic differentiation via a Hedgehog (Montrer SHH Kits ELISA) dependent mechanism.
Nfatc2 (Montrer NFAT1 Kits ELISA) likely plays an important role in Nell-1-mediated osteochondral differentiation in vitro and in vivo.
Nell-1 supports continued osteoblastic differentiation and function in osteoblastic lineage cells during calvarial development. Nell-1 is a key functional, downstream mediator of Runx2 (Montrer RUNX2 Kits ELISA) osteogenic activity.
A recessive, neonatal-lethal point mutation in the Nell1 gene causes cranial and skeletal defects.
lipoaspirate-derived hPSCs present a novel and abundant cell source of MSCs for cartilage regeneration, and the combinatorial application of NELL-1, TGF-beta3 (Montrer TGFB3 Kits ELISA), and BMP-6 (Montrer BMP6 Kits ELISA) with hPSCs may remarkably enhance and accelerate cartilage repair.
establish the feasibility of combining NELL-1 with BMP2 (Montrer BMP2 Kits ELISA) to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt (Montrer WNT2 Kits ELISA) pathway activity during NELL-1 and BMP2 (Montrer BMP2 Kits ELISA) osteogenesis
Data suggest that TSPN (N-terminal thrombospondin-1-like (Montrer THBS1 Kits ELISA)) domain of NELL1 exhibits major heparin-binding sites which may be involved in interaction of NELL1 with cell surface heparan sulfate proteoglycans.
NELL-1 signaling activates Wnt (Montrer WNT2 Kits ELISA)/beta-catenin (Montrer CTNNB1 Kits ELISA) signaling.
We also detected lower relative expression of Nell-1 by real-time PCR. Furthermore, immunohistochemical analyses revealed that Nell-1 staining was less intense in cancer tissue relative to normal tissue and that the tumor cells had spread to the muscle
CpG islands in the NELL1 and NELL2 (Montrer NELL2 Kits ELISA) promoters are hypermethylated in renal cell carcinoma.NELL1 and NELL2 (Montrer NELL2 Kits ELISA) protein expression is downregulated in clear cell renal carcinoma (Montrer TSC2 Kits ELISA).
NELL-1 demonstrates diffuse and reliable expression in benign but not malignant bone-forming skeletal tumors
NELL1 overexpression greatly enhanced the osteogenic differentiation and mineral synthesis of iPSC-MSCs on RGD-grafted CPC scaffold for the first time.
Two single-nucleotide polymorphisms of the NELL1 gene may represent a novel mechanism underlying hydrochlorothiazide-induced adverse metabolic effects (meta-analysis).
NELL1 is able to promote the osteogenic differentiation of periodontal ligament stem cells, which may be related to the downregulation of Msx2 expression.
This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Two transcript variants encoding different isoforms have been found for this gene.
NEL-like protein 1
, protein kinase C-binding protein NELL1
, NELL-1 protein short isoform
, nel-related protein 1
, neural epidermal growth factor-like 1