Naked Cuticle Homolog 1 (Drosophila) (NKD1) Kits ELISA

In the mouse, Nkd is a Dishevelled (see DVL1\\\\; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1\\\\; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003].. De plus, nous expédions Naked Cuticle Homolog 1 (Drosophila) Anticorps (33) et Naked Cuticle Homolog 1 (Drosophila) Protéines (3) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Souris NKD1 NKD1 93960 Q99MH6
Anti-Humain NKD1 NKD1 85407 Q969G9
Anti-Rat NKD1 NKD1 364952  
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Plus Kits ELISA pour Naked Cuticle Homolog 1 (Drosophila) partenaires d'interaction

Mouse (Murine) Naked Cuticle Homolog 1 (Drosophila) (NKD1) interaction partners

  1. deletion of the EF-hand from Nkd1 reduces the number of the elongating spermatids at haploid stage

  2. Viable mice were obtained with compound mutations in the Wnt (Montrer WNT2 Kits ELISA)/Dvl (Montrer DVL1 Kits ELISA) pathway antagonists nkd1 and nkd2 (Montrer NKD2 Kits ELISA).

Human Naked Cuticle Homolog 1 (Drosophila) (NKD1) interaction partners

  1. Data indicate that microRNA miR (Montrer MLXIP Kits ELISA)-744 activated Wnt (Montrer WNT2 Kits ELISA)/beta-catenin (Montrer CTNNB1 Kits ELISA) pathway by targeting multiple negative regulators of Wnt (Montrer WNT2 Kits ELISA)/beta-catenin (Montrer CTNNB1 Kits ELISA) signaling, including SFRP1 (Montrer SFRP1 Kits ELISA), GSK3beta (Montrer GSK3b Kits ELISA), TLE3 and NKD1, and that NKD1 is a major functional target of miR (Montrer MLXIP Kits ELISA)-744.

  2. NKD1 showed significantly increased level after induction chemotherapy achieved complete remission in follow-up paired acute myeloid leukemia (Montrer BCL11A Kits ELISA) patients ( p < 0.001). These findings indicated that reduced NKD1 expression is associated with unfavorable clinical outcome in cytogenetically normal acute myeloid leukemia (Montrer BCL11A Kits ELISA).

  3. Low NKD1 expression is associated with hepatocellular carcinoma.

  4. Silencing of NKD1 significantly inhibited the proliferation and invasion of osteosarcoma cells.

  5. Suggest that NKD1 plays an important role in invasion in human breast cancer and it appears to be a potential prognostic marker for patients with breast cancer.

  6. Reduced NKD1 protein expression correlates with a poor prognosis in NSCLC

  7. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt (Montrer WNT2 Kits ELISA)/Dvl (Montrer DVL2 Kits ELISA)/beta-catenin (Montrer CTNNB1 Kits ELISA) signaling

Zebrafish Naked Cuticle Homolog 1 (Drosophila) (NKD1) interaction partners

  1. Nkd1 activity is specifically dependent on Wnt (Montrer WNT2 Kits ELISA) ligand activation of the receptor. Nkd1 is recruited to the Wnt (Montrer WNT2 Kits ELISA) signalosome with Dvl2 (Montrer DVL2 Kits ELISA), where it becomes activated to move into the cytoplasm to interact with beta-catenin (Montrer CTNNB1 Kits ELISA), inhibiting its nuclear accumulation.

  2. Nkd1 functions as a passive antagonist of Wnt (Montrer WNT2 Kits ELISA) signaling, functioning only when homeostatic levels of Wnt (Montrer WNT2 Kits ELISA) signaling have been breached or when Wnt (Montrer WNT2 Kits ELISA) signaling becomes destabilized.

  3. Data demonstrate that Nkd1 binds to beta-catenin (Montrer CTNNB1 Kits ELISA) and prevents its nuclear accumulation. Nkd1 function is dependent on its interaction with the cell membrane.

  4. Nkd1 knockdown in the dorsal forerunner cells causes beta-catenin (Montrer CTNNB1 Kits ELISA) nuclear localization/transcriptional activation & changes in DFC migration, Kupffer's vesicle formation, ciliogenesis, left-right patterning, & asymmetric charon expression.

  5. data indicate that zebrafish Nkd1 and Nkd2 (Montrer NKD2 Kits ELISA) function to limit both canonical and non-canonical Wnt (Montrer WNT2 Kits ELISA) signaling

Naked Cuticle Homolog 1 (Drosophila) (NKD1) profil antigène

Antigen Summary

In the mouse, Nkd is a Dishevelled (see DVL1\; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1\; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.

Gene names and symbols associated with NKD1

  • naked cuticle homolog 1 (Drosophila) (NKD1) anticorps
  • naked cuticle 1 homolog (Drosophila) (Nkd1) anticorps
  • naked cuticle homolog 1 (Drosophila) (Nkd1) anticorps
  • naked cuticle homolog 1 (Drosophila) (nkd1) anticorps
  • 2810434J10Rik anticorps
  • 9030215G15Rik anticorps
  • Naked1 anticorps
  • Nkd anticorps

Protein level used designations for NKD1

naked cuticle homolog 1 (Drosophila) , mNkd , mNkd1 , naked-1 , protein naked cuticle homolog 1 , Dvl-binding protein , naked cuticle-1 , naked cuticle 1 homolog , naked 1

GENE ID SPECIES
487288 Canis lupus familiaris
93960 Mus musculus
415729 Gallus gallus
85407 Homo sapiens
618586 Bos taurus
364952 Rattus norvegicus
751108 Danio rerio
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