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anti-Neutrophil Cytosolic Factor 1 (NCF1) Anticorps

The protein encoded by NCF1 is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase.

afficher tous les anticorps Gène GeneID UniProt
Anti-Souris NCF1 NCF1 17969 Q09014
Anti-Humain NCF1 NCF1 653361 P14598
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Plus d’anticorps contre Neutrophil Cytosolic Factor 1 partenaires d’interaction

Mouse (Murine) Neutrophil Cytosolic Factor 1 (NCF1) interaction partners

  1. data partly explains the discrepancy of the phenotypes reported earlier utilizing the Ncf1m1J mice or Ncf1 knockout mice.

  2. Data (including data from studies in transgenic mice) suggest that ability to generate Ncf1-derived superoxide, specifically in CD4 (Montrer CD4 Anticorps)-positive T-lymphocytes, is key for development of autoimmune responses in type 1 diabetes.

  3. The Park7 (Montrer PARK7 Anticorps) binds to p47(phox), a subunit of the NADPH oxidase (Montrer NOX1 Anticorps), to promote NADPH oxidase (Montrer NOX1 Anticorps)-dependent production of ROS (Montrer ROS1 Anticorps).

  4. p47(phox)-dependent NADPH (Montrer FDXR Anticorps) oxidases are a major glomerular source of reactive oxygen species, contributing to kidney injury

  5. p47phox mRNA expression was increased in diet-induced obese (DIO) mice. p47phox suppresses collateral vessel growth after femoral artery ligation in DIO mice.

  6. These findings suggest that a p47(phox)-dependent NAD(P)H (Montrer NQO1 Anticorps) oxidase mediates the increase in diaphragm oxidants and contractile dysfunction in chronic heart failure.

  7. The present study provides evidence that augmented EGFRtk impairs vascular function by NADPH oxidase (Montrer NOX1 Anticorps)-dependent mechanism. Therefore, EGFRtk and oxidative stress should be potential targets to treat vascular dysfunction in TD2.

  8. NOX2 (Montrer CYBB Anticorps)/ROS (Montrer ROS1 Anticorps) activity in macrophages signals the development of antigen-specific CD8 (Montrer CD8A Anticorps)(+)T cell response.

  9. p47phox plays a critical role in the regulation of adventitial fibroblast proliferation and migration and may be a new therapeutic target for neointimal hyperplasia

  10. p47phox-Nox2 (Montrer CYBB Anticorps)-dependent physiological reactive oxygen species signaling suppresses inflammation in aging.

Human Neutrophil Cytosolic Factor 1 (NCF1) interaction partners

  1. A rare mutation in NCF1 encoding p47phox of the leukocyte NADPH oxidase (Montrer NOX1 Anticorps) causes lack of superoxide generation, leads to chronic granulomatous disease and was recently (1200-2300 years ago) introduced into the Kavkazi Jewish population

  2. Data show that diphenylene iodonium (DPI (Montrer DSP Anticorps)) and apocynin can reduce hyperoxia-induced reactive oxygen species (ROS (Montrer ROS1 Anticorps)) production by decreasing the translocation and level of NADPH Oxidase (Montrer NOX1 Anticorps) p47phox.

  3. increased levels of gp91phox (Montrer CYBB Anticorps), p47phox and p22phox (Montrer CYBA Anticorps) likely account for the interferon-gamma (Montrer IFNG Anticorps) mediated enhancement of dimethyl sulfoxide-induced Nox2 (Montrer CYBB Anticorps) activity.

  4. Results identifies p47phox-dependent NADPH oxidase (Montrer NOX1 Anticorps) activity as a critical component of Angpt-1 (Montrer ANGPT1 Anticorps)-mediated endothelial barrier defense against classic inflammatory permeability factors.

  5. DCLRE1C (Montrer DCLRE1C Anticorps) and NCF1 mutations have been found by whole-genome sequencing to cause primary immunodeficiency in unrelated patients.

  6. TLR8 (Montrer TLR8 Anticorps), but not TLR7 (Montrer TLR7 Anticorps), is involved in priming of human neutrophil reactive oxygen species production by inducing the phosphorylation of p47phox and p38 MAPK (Montrer MAPK14 Anticorps).

  7. Reduced carotid but not coronary artery atherosclerosis in patients with chronic granulomatous disease despite the high prevalence of traditional risk factors raises questions about the role of NADPH oxidase (Montrer NOX1 Anticorps) in the pathogenesis of atherosclerosis.

  8. Four novel mutations in the NCF1, NCF2 (Montrer NCF2 Anticorps), and CYBB (Montrer CYBB Anticorps) genees have been identified in chronic granulomatous disease patients in Morocco.

  9. Suggest eupafolin attenuated COX-2 (Montrer COX2 Anticorps) expression leading to reduced production of prostaglandin E2 by blocking Nox2 (Montrer CYBB Anticorps)/p47(phox) pathway.

  10. p47(phox) and Rac2 (Montrer RAC2 Anticorps) accumulate only transiently at the phagosome at the onset of NADPH (Montrer NQO1 Anticorps) activity and detach from the phagosome before the end of reactive oxygen species production.

Cow (Bovine) Neutrophil Cytosolic Factor 1 (NCF1) interaction partners

  1. two novel splice variants designed as NCF1-TV1 (retained intron 6) and NCF1-TV2 (retained part of intron 8)encoding two putative truncated proteins (239AA and 283AA). Two splice variants were up-regulated in the mastitis-infected cows' mammary tissues, blood and neutrophils compared with these of healthy cows.

  2. A p47(phox) and Src kinase (Montrer CSK Anticorps) activation of peroxide production by Nox2 (Montrer CYBB Anticorps) appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C (Montrer PKC Anticorps).

Neutrophil Cytosolic Factor 1 (NCF1) profil antigène

Profil protéine

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.

Gene names and symbols associated with NCF1

  • neutrophil cytosolic factor 1 (p47phox) anticorps
  • general transcription factor IIi (GTF2I) anticorps
  • neutrophil cytosolic factor 1 (Ncf1) anticorps
  • neutrophil cytosolic factor 1 (NCF1) anticorps
  • neutrophil cytosolic factor 1 (ncf1) anticorps
  • cb893 anticorps
  • Ncf-1 anticorps
  • NCF1A anticorps
  • NOXO2 anticorps
  • p47 anticorps
  • p47phox anticorps
  • SH3PXD1A anticorps

Protein level used designations for NCF1

neutrophil cytosolic factor 1 , 47 kDa neutrophil oxidase factor , NADPH oxidase subunit (47 kD) , NADPH oxidase subunit (47kDa) , NCF-47K , neutrophil NADPH oxidase factor 1 , neutrophil cytosol factor 1 , p47-phox , 47 kDa autosomal chronic granulomatous disease protein , NADPH oxidase organizer 2 , NCF-1 , SH3 and PX domain-containing protein 1A , neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) , nox organizer 2 , nox-organizing protein 2 , neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1) , p47phox

GENE ID SPECIES
619225 Ciona intestinalis
100227162 Taeniopygia guttata
17969 Mus musculus
653361 Homo sapiens
281345 Bos taurus
378966 Danio rerio
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