anti-Neutrophil Cytosolic Factor 1 (NCF1) Anticorps

The protein encoded by NCF1 is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase.

afficher tous les anticorps Gène GeneID UniProt
Anti-Souris NCF1 NCF1 17969 Q09014
Anti-Humain NCF1 NCF1 653361 P14598
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Plus d’anticorps contre Neutrophil Cytosolic Factor 1 partenaires d’interaction

Mouse (Murine) Neutrophil Cytosolic Factor 1 (NCF1) interaction partners

  1. The authors demonstrated a significant role of the host NADPH oxidase (Montrer NOX1 Anticorps) in promoting chronic inflammatory pathology in the oviduct following chlamydial infection.

  2. data partly explains the discrepancy of the phenotypes reported earlier utilizing the Ncf1m1J mice or Ncf1 knockout mice.

  3. Data (including data from studies in transgenic mice) suggest that ability to generate Ncf1-derived superoxide, specifically in CD4 (Montrer CD4 Anticorps)-positive T-lymphocytes, is key for development of autoimmune responses in type 1 diabetes.

  4. The Park7 (Montrer PARK7 Anticorps) binds to p47(phox), a subunit of the NADPH oxidase (Montrer NOX1 Anticorps), to promote NADPH oxidase (Montrer NOX1 Anticorps)-dependent production of ROS (Montrer ROS1 Anticorps).

  5. p47(phox)-dependent NADPH oxidases are a major glomerular source of reactive oxygen species, contributing to kidney injury

  6. p47phox mRNA expression was increased in diet-induced obese (DIO) mice. p47phox suppresses collateral vessel growth after femoral artery ligation in DIO mice.

  7. These findings suggest that a p47(phox)-dependent NAD(P)H (Montrer NQO1 Anticorps) oxidase mediates the increase in diaphragm oxidants and contractile dysfunction in chronic heart failure.

  8. The present study provides evidence that augmented EGFRtk impairs vascular function by NADPH oxidase (Montrer NOX1 Anticorps)-dependent mechanism. Therefore, EGFRtk and oxidative stress should be potential targets to treat vascular dysfunction in TD2.

  9. NOX2 (Montrer CYBB Anticorps)/ROS (Montrer ROS1 Anticorps) activity in macrophages signals the development of antigen-specific CD8 (Montrer CD8A Anticorps)(+)T cell response.

  10. p47phox plays a critical role in the regulation of adventitial fibroblast proliferation and migration and may be a new therapeutic target for neointimal hyperplasia

Human Neutrophil Cytosolic Factor 1 (NCF1) interaction partners

  1. Decreased and increased copy numbers of NCF1 predispose to and protect against SLE.

  2. Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (Montrer HCK Anticorps)-dependent activation of PKCdelta (Montrer PKCd Anticorps), which stimulates PKCgamma (Montrer PRKCG Anticorps), resulting in translocation of phosphorylated p47(phox).

  3. There was an increased frequency of the NCF1-339 T allele in patients with systemic lupus erythematosus. The NCF1-339 T allele reduced extracellular ROS (Montrer ROS1 Anticorps) production in neutrophils and led to an increase expression of type 1 interferon (Montrer IFNA Anticorps)-regulated genes.

  4. Skeletal muscle protein expression of the NADPH oxidase (Montrer NOX1 Anticorps) subunits p22(phox (Montrer CYBA Anticorps)), p47(phox), and p67(phox (Montrer NCF2 Anticorps)) was increased in obese relative to lean subjects, where p22(phox (Montrer CYBA Anticorps)) and p67(phox (Montrer NCF2 Anticorps)) expression was attenuated by exercise training in obese subjects.

  5. A novel role for Spns2 (Montrer SPNS2 Anticorps) and S1P1 (Montrer S1PR1 Anticorps)&2 in the activation of p47(phox) and production of reactive oxygen species involved in hyperoxia-mediated lung injury.

  6. Study provides evidence for a novel PKC-zeta (Montrer PRKCZ Anticorps) to p47phox interaction that is required for cell transformation from blebbishields and ROS (Montrer ROS1 Anticorps) production in cancer cells.

  7. Overexpression of p47phox is associated with increased migration/metastasis rate in melanoma.

  8. A rare mutation in NCF1 encoding p47phox of the leukocyte NADPH oxidase (Montrer NOX1 Anticorps) causes lack of superoxide generation, leads to chronic granulomatous disease and was recently (1200-2300 years ago) introduced into the Kavkazi Jewish population

  9. Data show that diphenylene iodonium (DPI (Montrer DSP Anticorps)) and apocynin can reduce hyperoxia-induced reactive oxygen species (ROS (Montrer ROS1 Anticorps)) production by decreasing the translocation and level of NADPH Oxidase (Montrer NOX1 Anticorps) p47phox.

  10. increased levels of gp91phox (Montrer CYBB Anticorps), p47phox and p22phox (Montrer CYBA Anticorps) likely account for the interferon-gamma (Montrer IFNG Anticorps) mediated enhancement of dimethyl sulfoxide-induced Nox2 (Montrer CYBB Anticorps) activity.

Cow (Bovine) Neutrophil Cytosolic Factor 1 (NCF1) interaction partners

  1. Differential Roles of Protein Complexes NOX1 (Montrer NOX1 Anticorps)-NOXO1 (Montrer NOXO1 Anticorps) and NOX2 (Montrer CYBB Anticorps)-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress.

  2. two novel splice variants designed as NCF1-TV1 (retained intron 6) and NCF1-TV2 (retained part of intron 8)encoding two putative truncated proteins (239AA and 283AA). Two splice variants were up-regulated in the mastitis-infected cows' mammary tissues, blood and neutrophils compared with these of healthy cows.

  3. A p47(phox) and Src kinase (Montrer CSK Anticorps) activation of peroxide production by Nox2 (Montrer CYBB Anticorps) appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C (Montrer PKC Anticorps).

Neutrophil Cytosolic Factor 1 (NCF1) profil antigène

Profil protéine

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.

Gene names and symbols associated with NCF1

  • neutrophil cytosolic factor 1 (p47phox) anticorps
  • general transcription factor IIi (GTF2I) anticorps
  • neutrophil cytosolic factor 1 (Ncf1) anticorps
  • neutrophil cytosolic factor 1 (NCF1) anticorps
  • neutrophil cytosolic factor 1 (ncf1) anticorps
  • cb893 anticorps
  • Ncf-1 anticorps
  • NCF1A anticorps
  • NOXO2 anticorps
  • p47 anticorps
  • p47phox anticorps
  • SH3PXD1A anticorps

Protein level used designations for NCF1

neutrophil cytosolic factor 1 , 47 kDa neutrophil oxidase factor , NADPH oxidase subunit (47 kD) , NADPH oxidase subunit (47kDa) , NCF-47K , neutrophil NADPH oxidase factor 1 , neutrophil cytosol factor 1 , p47-phox , 47 kDa autosomal chronic granulomatous disease protein , NADPH oxidase organizer 2 , NCF-1 , SH3 and PX domain-containing protein 1A , neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) , nox organizer 2 , nox-organizing protein 2 , neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1) , p47phox

GENE ID SPECIES
619225 Ciona intestinalis
100227162 Taeniopygia guttata
17969 Mus musculus
653361 Homo sapiens
281345 Bos taurus
378966 Danio rerio
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