Neutrophil Cytosolic Factor 2 Protéines (NCF2)

NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. De plus, nous expédions NCF2 Anticorps (50) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NCF2 4688 P19878
NCF2 17970 O70145
NCF2 364018 A7E3N2
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Showing 9 out of 12 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$7,759.50
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$7,759.50
Détails
HOST_Baculovirus infected Insect Cells Humain Inconjugué 100 μg Connectez-vous pour afficher 20 to 21 Days
$382.80
Détails
HOST_Escherichia coli (E. coli) Humain His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$640.00
Détails
HOST_Escherichia coli (E. coli) Souris His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$656.00
Détails
HOST_HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 10 to 12 Days
$785.40
Détails
HOST_Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$405.71
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,501.67
Détails
HOST_Escherichia coli (E. coli) Souris Inconjugué   100 μg Connectez-vous pour afficher 11 to 18 Days
$852.50
Détails

NCF2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , ,
, , , ,
Mouse (Murine) ,
,
Rat (Rattus)

Plus protéines pour Neutrophil Cytosolic Factor 2 (NCF2) partenaires d'interaction

Pig (Porcine) Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. analysis of NCF2, BCKDHB (Montrer BCKDHB Protéines) and BCKDHA (Montrer BCKDHA Protéines) in pig

Human Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox (Montrer NCF4 Protéines) and p67phox at the phagosomal membrane.

  2. TLR4 (Montrer TLR4 Protéines)- and TLR2-induced IRAK (Montrer IRAK1 Protéines)-ERK (Montrer EPHB2 Protéines) pathway cross-talks with p67phox-Nox-2 (Montrer CYBB Protéines) for reactive oxygen species generation, thus regulating IL-1beta (Montrer IL1B Protéines) transcription and processing in monocytic cells.

  3. Skeletal muscle protein expression of the NADPH oxidase (Montrer NOX1 Protéines) subunits p22(phox (Montrer CYBA Protéines)), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox (Montrer CYBA Protéines)) and p67(phox) expression was attenuated by exercise training in obese subjects.

  4. A novel homozygous mutation in NCF2.

  5. results reveal an essential role for the Cys (Montrer DNAJC5 Protéines)-Gly-Cys (Montrer DNAJC5 Protéines) triad in Nox2 (Montrer CYBB Protéines) in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys (Montrer DNAJC5 Protéines)-Gly-Cys (Montrer DNAJC5 Protéines). The 2 regions interact with distinct partner sites in p67(phox).

  6. This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4 (Montrer NCF4 Protéines)/VAV1 (Montrer VAV1 Protéines)/RAC1 NADPH oxidase (Montrer NOX1 Protéines) complex.

  7. Data indicate that arachidonic acid induces the direct interaction of Rac (Montrer AKT1 Protéines)-GTP (Montrer AK3 Protéines)-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase (Montrer NOX1 Protéines) Nox2 (Montrer CYBB Protéines).

  8. Four novel mutations in the NCF1 (Montrer NCF1 Protéines), NCF2, and CYBB (Montrer CYBB Protéines) genees have been identified in chronic granulomatous disease patients in Morocco.

  9. Results not only establish allelic heterogeneity within NCF2 associated with SLE, but also emphasize the utility of multi-ethnic cohorts to identify predisposing variants explaining additional phenotypic variance of complex diseases like SLE.

  10. NCF2 in Asian populations shows a pattern of diversity characterized by a differentiated haplotype structure.

Mouse (Murine) Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. Just as patients with chronic granulomatous disease who lack NADPH oxidase (Montrer NOX1 Protéines) rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.

  2. p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 (Montrer PLA2G2A Protéines) activity, an interaction that could function to terminate the PLA2 (Montrer PLA2G2A Protéines)-mediated NOX2 (Montrer CYBB Protéines) activation signal.

  3. The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH (Montrer FDXR Protéines) oxidasesubunit (67kDa (Montrer RPSA Protéines)) and the resultant metabolic oxidative stress.

  4. Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2 (Montrer CYBB Protéines)), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4 (Montrer SLC2A4 Protéines)-/-) mice.

  5. This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.

  6. This study demonstrates the involvement of ROS (Montrer ROS1 Protéines) from NADPH oxidase (Montrer NOX1 Protéines) in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta (Montrer PKCd Protéines)- and ERK (Montrer EPHB2 Protéines)-dependent pathways.

Profil protéine NCF2

Profil protéine

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with NCF2

  • neutrophil cytosolic factor 2 (NCF2)
  • neutrophil cytosolic factor 2 (ncf2)
  • neutrophil cytosolic factor 2 (p67phox)
  • neutrophil cytosol factor 2 (VDBG_06643)
  • neutrophil cytosolic factor 2 (PGTG_05816)
  • neutrophil cytosolic factor 2 (LOC100136240)
  • neutrophil cytosolic factor 2 (Ncf2)
  • MGC81877 Protéine
  • Ncf-2 Protéine
  • NOXA2 Protéine
  • P67-PHOX Protéine
  • P67PHOX Protéine
  • zgc:158405 Protéine

Protein level used designations for NCF2

neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) , neutrophil cytosolic factor 2 , neutrophil cytosol factor 2 , predicted neutrophil cytosolic factor 2 , p67phox , p67-phox , NADPH oxidase cytosolic protein p67phox , NADPH oxidase cytosolic protein , 67 kDa neutrophil oxidase factor , NADPH oxidase activator 2 , chronic granulomatous disease, autosomal 2 , neutrophil NADPH oxidase factor 2 , neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2) , NADPH oxidase subunit (67 kD) , NADPH oxidase subunit (67kDa) , NCF-2

GENE ID SPECIES
424445 Gallus gallus
444487 Xenopus laevis
457573 Pan troglodytes
480036 Canis lupus familiaris
562473 Danio rerio
619224 Ciona intestinalis
619367 Xenopus (Silurana) tropicalis
9537124 Verticillium alfalfae VaMs.102
10531323 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100008802 Oryctolagus cuniculus
100136240 Oncorhynchus mykiss
100142665 Sus scrofa
100174692 Pongo abelii
100270811 Salmo salar
4688 Homo sapiens
17970 Mus musculus
364018 Rattus norvegicus
281346 Bos taurus
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