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Neutrophil Cytosolic Factor 4, 40kDa (NCF4) Kits ELISA

The protein encoded by NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. De plus, nous expédions Neutrophil Cytosolic Factor 4, 40kDa Anticorps (118) et Neutrophil Cytosolic Factor 4, 40kDa Protéines (9) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Souris NCF4 NCF4 17972 P97369
Anti-Rat NCF4 NCF4 500904  
Anti-Humain NCF4 NCF4 4689 Q15080
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Plus Kits ELISA pour Neutrophil Cytosolic Factor 4, 40kDa partenaires d'interaction

Mouse (Murine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. p40phox deficiency leads to upregulation of chemokine receptor 1 (Montrer CMKLR1 Kits ELISA) and downregulation of fucosyltransferases and sialyltransferases involved in glycan modifications during experimental intestinal inflammation.

  2. cooperation of p40(phox) with p47(phox) for Nox2 (Montrer CYBB Kits ELISA)-based NADPH oxidase (Montrer NOX1 Kits ELISA) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

  3. The defect in Reactive Oxygen Species production and killing of s aureus by p40(phox-/-) neutrophils defines p40(phox) as an essential component in bacterial killing.

  4. p40 (Montrer LANCL1 Kits ELISA)(phoxR58A/R58A) embryos do not develop normally but p40 (Montrer LANCL1 Kits ELISA)(phoxR58A/-) mice are viable and neutrophils from these animals exhibit significantly reduced oxidase responses compared to those from their p40(phox+/-) siblings.

  5. Class III PI3K Vps34 (Montrer PIK3C3 Kits ELISA) is responsible for the synthesis of PtdIns(3)P on phagosomes containing either S aureus or E coli. PtdIns(3)P binding to p40(phox) is important for CD18 (Montrer ITGB2 Kits ELISA)-dependent activation oxidase activation in response to S aureus and E coli

  6. p40(phox) is prephosphorylated in resting endothelial cells and can compensate p47(phox) in keeping basal ROS (Montrer ROS1 Kits ELISA) production.

Human Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. NCF4 polymorphism was associated with Crohn's disease, but not ulcerative colitis in Caucasian--{REVIEW}

  2. NCF4 may induce ex- pression of NADPH oxidase (Montrer NOX1 Kits ELISA) enzymes, such as p67phox (Montrer NCF2 Kits ELISA), p47phox (Montrer NCF1 Kits ELISA), p22phox (Montrer CYBA Kits ELISA) and NOX2 (Montrer CYBB Kits ELISA), which lead to increased ROS (Montrer ROS1 Kits ELISA) levels.

  3. Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer.

  4. The contribution of the functionally relevant NADPH (Montrer NQO1 Kits ELISA) polymorphisms rs1883112 and rs4673 to anthracycline-related heart lesions provides a plausible explanation for their modulation of cardiotoxicity.

  5. Constitutive and inducible intracellular production of reactive oxygen species (ROS (Montrer ROS1 Kits ELISA)) is higher in B cells expressing functional p40phox, supporting a direct role for p40phox in regulating B cell intracellular ROS (Montrer ROS1 Kits ELISA) generation.

  6. Genome-wide association studies-reported associations between the NELL1, NCF4, and FAM92B genes and susceptibility to Crohn's disease could not be replicated in Canadian children and young adults.

  7. Younger age at diagnosis, complicated disease behavior, and ileal disease location are risk factors for perianal CD. First report of an association of the NCF4 gene with perianal disease.

  8. cooperation of p40(phox) with p47(phox) for Nox2 (Montrer CYBB Kits ELISA)-based NADPH oxidase (Montrer NOX1 Kits ELISA) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

  9. Results demonstrate that PBEF (Montrer NAMPT Kits ELISA) can prime for PMN (Montrer TBCE Kits ELISA) respiratory burst activity by promoting p40 (Montrer IL9 Kits ELISA) and p47 (Montrer ING1 Kits ELISA) translocation to the membrane.

  10. cytosolic localisation depends on direct interaction with F-actin

Cow (Bovine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. Study proposes that NCF4 splice variants generated by functional SNP are important risk factors for mastitis susceptibility in dairy cows.

Neutrophil Cytosolic Factor 4, 40kDa (NCF4) profil antigène

Antigen Summary

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with NCF4

  • p40phox protein (p40phox) anticorps
  • neutrophil cytosolic factor 4 (LOC100136241) anticorps
  • neutrophil cytosolic factor 4 (Ncf4) anticorps
  • neutrophil cytosolic factor 4, 40kDa (NCF4) anticorps
  • AI451400 anticorps
  • NCF anticorps
  • P40PHOX anticorps
  • SH3PXD4 anticorps

Protein level used designations for NCF4

p40phox protein , neutrophil cytosolic factor 4 , NADPH oxidase cytosolic protein p40phox , NCF-4 , neutrophil NADPH oxidase factor 4 , neutrophil cytosol factor 4 , p40-phox , SH3 and PX domain-containing protein 4

GENE ID SPECIES
445891 Takifugu rubripes
100136241 Oncorhynchus mykiss
17972 Mus musculus
500904 Rattus norvegicus
4689 Homo sapiens
481277 Canis lupus familiaris
507859 Bos taurus
100009359 Oryctolagus cuniculus
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