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The protein encoded by PAK7 is a member of the PAK family of Ser/Thr protein kinases. De plus, nous expédions PAK7 Protéines (13) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal PAK7 Primary Antibody pour ICC, ELISA - ABIN1002958
Jaffer, Chernoff: p21-activated kinases: three more join the Pak. dans The international journal of biochemistry & cell biology 2002
Show all 3 Pubmed References
Data suggest expression of ECAD (E-cadherin (Montrer CDH1 Anticorps)) in bladder cancer cell lines correlates with presence of intercellular junctions and level of PAK5 (Montrer PAK6 Anticorps) (p21 (Montrer CDKN1A Anticorps)-activated kinase PAK5 (Montrer PAK6 Anticorps) protein) expression; endogenous PAK5 (Montrer PAK6 Anticorps) is localized to intercellular junctions and interacts with ECAD (Montrer CDH1 Anticorps); depletion of PAK5 (Montrer PAK6 Anticorps) expression reduces integrity of intercellular junctions; PAK5 (Montrer PAK6 Anticorps) mRNA levels are reduced in bladder cancer compared with normal controls.
model suggests PAK5 self-association interferes with AID binding to the catalytic domain, thus maintaining its high activity.
PAK7 expression is significantly downregulated in human masticatory mucosa during wound healing
PAK7 is overexpressed in human esophageal squamous cell cancer samples and correlated with lymph node metastasis.
E47 (Montrer TCF3 Anticorps) is a novel substrate of PAK5 (Montrer PAK6 Anticorps), and PAK5 (Montrer PAK6 Anticorps)-mediated phosphorylation of E47 (Montrer TCF3 Anticorps) promotes epithelial-mesenchymal transition and metastasis of colon cancer.
Aurora-A induced PAK7 expression in esophageal cancer cells.
results suggest that the inhibition of PAK5 by RNA interference might efficiently suppress tumor development of glioma cells with PAK5 high expression.
miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma.
PAK7 promotes cell proliferation and tumorigenesis
It inhibits glioma cell migration and invasion potentially through the PAK5 (Montrer PAK6 Anticorps)-Egr1 (Montrer EGR1 Anticorps)-MMP2 (Montrer MMP2 Anticorps) signaling pathway.
Xenopus PAK5 regulates convergent extension movements in vivo by modulating the calcium-mediated cell-cell adhesion in blastomeres.
PAK-7 p21-activated kinase 5 knockout mice are more sensitive to the stimulant effects of amphetamine
functional deficits in PAK5, PAK6 (Montrer PAK6 Anticorps) and PAK5/PAK6 (Montrer PAK6 Anticorps) knockout mice
PAK 5 is involved in formalin-induced inflammatory nociception through regulation of MAPK-induced c-Fos-activation and formalin-specific transient receptor potential-channels.
These results implicate Pak5 in Pacsin1 (Montrer PACSIN1 Anticorps)- and Synaptojanin1-mediated synaptic vesicle trafficking.
PAK5 may provide a molecular rationale for late-stage complications in diabetes.
Our results indicate that Pak5 and Pak6 (Montrer PAK6 Anticorps) together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory.
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.
, p21(CDKN1A)-activated kinase 7
, p21-activated kinase 5
, p21-activated kinase 7
, p21CDKN1A-activated kinase 7
, protein kinase PAK5
, serine/threonine-protein kinase PAK 7
, serine/threonine-protein kinase PAK7
, p21 (CDKN1A)-activated kinase 7