Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

PLEC Kits ELISA

(Plectin (PLEC))
Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human\; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974)\; exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011].
PLEC Kit ELISA PLEC Kit ELISA PLEC Kit ELISA (ABIN6969427)

PLEC Reactivité: Humain Colorimetric Sandwich ELISA 0.313 ng/mL - 20 ng/mL Plasma, Serum, Tissue Homogenate

PLEC Kit ELISA PLEC Kit ELISA PLEC Kit ELISA (ABIN6958656)

PLEC Reactivité: Humain Colorimetric Sandwich ELISA 1.56 ng/mL - 100 ng/mL Cell Lysate, Tissue Homogenate

PLEC Kit ELISA PLEC Kit ELISA PLEC Kit ELISA (ABIN6958657)

PLEC Reactivité: Rat Colorimetric Sandwich ELISA 0.78 ng/mL - 50 ng/mL Cell Lysate, Tissue Homogenate

PLEC Kits ELISA par Réactivité

Trouvez PLEC Kits ELISA pour une variété d'espèces telles que anti-Human PLEC, anti-Mouse PLEC, anti-Rat PLEC. Les espèces listées ci-dessous sont parmi celles disponibles. Cliquez sur un lien pour accéder aux produits correspondants.

PLEC Kits ELISA par Méthode de détection

On trouve ici des PLEC Kits ELISA avec un Méthode de détection spécifique. Les Méthode de détection mentionnés ici sont quelques-uns de ceux qui sont disponibles. Un clic sur le lien correspondant permet d'accéder aux produits

PLEC Kits ELISA par Analytical Method

On trouve ici des PLEC Kits ELISA avec un Analytical Method spécifique. Les Analytical Method mentionnés ici sont quelques-uns de ceux qui sont disponibles. Un clic sur le lien correspondant permet d'accéder aux produits

PLEC Kits ELISA par Type de méthode

On trouve ici des PLEC Kits ELISA avec un Type de méthode spécifique. Les Type de méthode mentionnés ici sont quelques-uns de ceux qui sont disponibles. Un clic sur le lien correspondant permet d'accéder aux produits

PLEC Kits ELISA par Sample

On trouve ici des PLEC Kits ELISA avec un Sample spécifique. Les Sample mentionnés ici sont quelques-uns de ceux qui sont disponibles. Un clic sur le lien correspondant permet d'accéder aux produits

PLEC Kits ELISA fréquemment utilisés

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969427
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6958656
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6958657
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN5593036
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Sandwich ELISA
Validations
N° du produit ABIN433086
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6210115
Quantité 96 tests
Fiche technique Fiche technique

Pseudonymes pour PLEC Kits ELISA

plectin (LOC100481602) Kits ELISA
plectin L homeolog (plec.L) Kits ELISA
plectin (PLEC) Kits ELISA
plectin (Plec) Kits ELISA
plectin (LOC786966) Kits ELISA
AA591047 Kits ELISA
AU042537 Kits ELISA
EBS1 Kits ELISA
EBSO Kits ELISA
HD1 Kits ELISA
IFAP300 Kits ELISA
LGMD2Q Kits ELISA
PCN Kits ELISA
Pcn Kits ELISA
PLEC1 Kits ELISA
Plec1 Kits ELISA
PLEC1b Kits ELISA
Plectin-1 Kits ELISA
PLTN Kits ELISA
Pltn Kits ELISA
Vous êtes ici:
Support technique