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The protein encoded by PLK2 is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. De plus, nous expédions Polo-Like Kinase 2 Anticorps (59) et Polo-Like Kinase 2 Protéines (12) et beaucoup plus de produits pour cette protéine.
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Plk2 represents an independent prognostic marker and regulates tumor growth and apoptosis by targeting Fbxw7 (Montrer FBXW7 Kits ELISA)/Cyclin E (Montrer CCNE1 Kits ELISA) pathway in colorectal carcinoma.
PLK2 kinase has a role in mediating alpha-synuclein (Montrer SNCA Kits ELISA) selective autophagic degradation
PLK2, functional kinase and polo (Montrer PLK1 Kits ELISA)-box domains were required for interaction with PFV Gag. Fluorescently-tagged PFV Gag, through its chromatin tethering function, selectively relocalized ectopically expressed eGFP-tagged PLK (Montrer PLK1 Kits ELISA) proteins to mitotic chromosomes i
Develop a DDS for continuous intracellular delivery of PLK2.
Structural analysis of the polo (Montrer PLK1 Kits ELISA)-box domain of human PLK2 has been presented.
our study demonstrates a novel mechanism of PLK2 in promoting tumor progression, whereby it directly binds to enriched TAp73 (Montrer TP73 Kits ELISA), catalyzes Ser48 phosphorylation of TAp73 (Montrer TP73 Kits ELISA), and inhibits TAp73 (Montrer TP73 Kits ELISA) transcriptional activity
Data suggest wild-type SNCA (alpha-synuclein (Montrer SNCA Kits ELISA)) binding to synaptosome membrane is not affected by phosphorylation by PLK2; A30P SNCA (Montrer SNCA Kits ELISA), a Parkinson disease mutation, binding is greatly increased; endocytosis of SNCA (Montrer SNCA Kits ELISA) fibrils follows similar pattern.
Decreased PLK2 protein expression due to promoter hypermethylation was negatively correlated with JAK2 (Montrer JAK2 Kits ELISA) overexpression, a common occurrence in hematological malignancies.
PLK2 SNPs were associated with Alzheimer disease and mild cognitive impairment. PLK2-rs15009 CC and GG genotypes and CC genotype at PLK2-rs702723 were protective for AD.
PLK2 indirectly activates ROCK2 (Montrer ROCK2 Kits ELISA) via phosphorylating nucleophosmin (Montrer NPM1 Kits ELISA) during centrosome amplification.
miR-146a regulates lineage negative bone marrow cell senescence and apoptosis by suppressing Plk2 expression that, in turn, activates p16Ink4a/p19Arf and p53 signaling.
These results support a significant role for a PLK (Montrer PLK1 Kits ELISA) kinase in phosphorylating alpha-synuclein (Montrer SNCA Kits ELISA) at Ser129 in the brain, and suggest that PLK2 is responsible for this activity under physiological conditions.
In support of a tumor suppressor function for Plk2, loss of Plk2 increased the formation of lesions in multiparous glands. Collectively, these results demonstrate a novel role for Plk2 in regulating mammary gland development.
c-Fos and polo-like kinase 2 induction is impaired in the limbic system of fear-conditioned alpha-synuclein (Montrer SNCA Kits ELISA) transgenic mice
PLK2 inhibition is a tractable CNS pharmacological target that does not cause genotoxicity at doses and exposures that engage the target in the sensory retina.
perturbation of Plk2 disrupts Ras and Rap (Montrer LRPAP1 Kits ELISA) signaling, prevents homeostatic shrinkage and loss of dendritic spines, and impairs proper memory formation.
CIB (Montrer CIB1 Kits ELISA) co-immunoprecipitated with Snk (Montrer ATP1A4 Kits ELISA) and inhibited the kinase activity of Snk (Montrer ATP1A4 Kits ELISA), suggesting that CIB (Montrer CIB1 Kits ELISA) is a negative regulator for Snk (Montrer ATP1A4 Kits ELISA) kinase activity.
there is a mitotic checkpoint (Montrer BUB3 Kits ELISA) wherein p53 (Montrer TP53 Kits ELISA)-dependent activation of Snk/Plk2 prevents mitotic catastrophe following spindle damage
PLK2 directly phosphorylates alpha-synuclein (Montrer SNCA Kits ELISA) at Ser (Montrer SIGLEC1 Kits ELISA)-129 in an in vitro biochemical assay
Here we show that CHK-2 promotes pairing and synapsis by phosphorylating a family of zinc finger proteins that bind to specialized regions on each chromosome known as pairing centers, priming their recruitment of the Polo-like kinase PLK (Montrer PLK1 Kits ELISA)-2.
Polo kinases, via their polo box domains, bind to and regulate the activity of two key polarity proteins, MEX-5 and MEX-6.
The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, serine/threonine-protein kinase PLK2
, serine/threonine-protein kinase SNK
, serum-inducible kinase
, polo-like kinase 1
, polo-like kinase 2 (Drosophila)
, polo-like kinase 2
, Serine/threonine-protein kinase PLK2
, serine/threonine-protein kinase PLK2-like