Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 Protéines (KCNJ15)

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. De plus, nous expédions KCNJ15 Anticorps (38) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
KCNJ15 3772 Q99712
KCNJ15 16516 O88932
Rat KCNJ15 KCNJ15 170847 Q91ZF1
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$5,442.50
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$4,244.78
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$405.71
Détails

KCNJ15 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
, ,
Mouse (Murine)
,

Plus protéines pour Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 (KCNJ15) partenaires d'interaction

Human Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 (KCNJ15) interaction partners

  1. KCNJ15 couples with polyamines in sensing weak electric fields.

  2. RNA-seq evidence of biallelic expression of KCNJ15 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of KCNJ15 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB (Montrer WRB Protéines) differentially methylated region (DMR (Montrer WDR20 Protéines)) in disomic controls or trisomy (Down syndrome) individuals.

  3. KCNJ15 has a major role in histamine-stimulated gastric acid secretion.

  4. We had performed a replication study using an independent larger Japanese population for the association of rs3746876 within KCNJ15, and observed a significant association of rs3746876 with type 2 diabetes, but this study failed to find original finding.

  5. It was shown that downregulation of Kcnj15 leads to increased insulin (Montrer INS Protéines) secretion in vitro and in vivo. The mechanism for regulating insulin (Montrer INS Protéines) secretion inolved a calcium-sensiong receptor.

  6. KCNJ15 is a previously unreported susceptibility gene for T2DM among Asians

  7. The potential synergy and consequences of the overexpression of KIR4.2 and KIR3.2 (Montrer KCNJ6 Protéines) in Down's syndrome brain development are discussed.

  8. Calcium-sensing receptor (Montrer CASR Protéines) interacts directly with Kir4.1 (Montrer KCNJ10 Protéines) and Kir4.2 and can decrease their currents.

  9. MUPP1 and Kir4.2 may participate in a protein complex in the nephron that could regulate transport of K(+) as well as other ions.

Mouse (Murine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 (KCNJ15) interaction partners

  1. Data show that KCNJ15 inward rectifier potassium channel and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents are changed in Trisomic neuron.

  2. It was shown that downregulation of Kcnj15 leads to increased insulin (Montrer INS Protéines) secretion in vitro and in vivo. The mechanism for regulating insulin (Montrer INS Protéines) secretion inolved a calcium-sensiong receptor.

  3. in nonsecreting parietal cells, KCNJ15 is stored in vesicles distinct from the H(+)-K(+)-ATPase (Montrer ATP4b Protéines)-enriched tubulovesicles. Furthermore, upon stimulation, KCNJ15 and H(+)-K(+)-ATPase (Montrer ATP4b Protéines) both translocate to the apical membrane for active acid secretion.

Profil protéine KCNJ15

Profil protéine

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with KCNJ15

  • potassium voltage-gated channel subfamily J member 15 (KCNJ15)
  • potassium channel, inwardly rectifying subfamily J, member 15 L homeolog (kcnj15.L)
  • potassium inwardly-rectifying channel, subfamily J, member 15 (Kcnj15)
  • potassium voltage-gated channel subfamily J member 15 (Kcnj15)
  • 4930414N08Rik Protéine
  • AI182284 Protéine
  • AI267127 Protéine
  • IRKK Protéine
  • kcnj1 Protéine
  • KCNJ15 Protéine
  • KIR1.3 Protéine
  • Kir4.2 Protéine
  • MGC68935 Protéine

Protein level used designations for KCNJ15

ATP-sensitive inward rectifier potassium channel 15 , inward rectifier K(+) channel Kir1.3 , inward rectifier K(+) channel Kir4.2 , inward rectifier K+ channel KIR4.2 , potassium channel, inwardly rectifying subfamily J member 15 , potassium inwardly-rectifying channel, subfamily J, member 15 , potassium inwardly-rectifying channel, subfamily J, member 1 , inward rectifier K+ channel Kir4.2 , potassium inwardly-rectifying channel J15 , Potassium channel, inwardly rectifying subfamily J member 15

GENE ID SPECIES
3772 Homo sapiens
379692 Xenopus laevis
16516 Mus musculus
170847 Rattus norvegicus
427984 Gallus gallus
487759 Canis lupus familiaris
522184 Bos taurus
693427 Macaca mulatta
747512 Pan troglodytes
100602180 Nomascus leucogenys
100713999 Cavia porcellus
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