Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) Kits ELISA

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. De plus, nous expédions Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Anticorps (69) et Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Humain KCNA2 KCNA2 3737 P16389
Anti-Souris KCNA2 KCNA2 16490 P63141
Anti-Rat KCNA2 KCNA2 25468 P63142
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Plus Kits ELISA pour Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 partenaires d'interaction

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) interaction partners

  1. Pharmacogenetic and case-control study evaluated the role of the variants of KCNA1 (Montrer KCNA1 Kits ELISA), KCNA2, and KCNV2 (Montrer KCNV2 Kits ELISA) in the susceptibility and drug resistance of genetic generalized epilepsies and revealed no significant association between 8 variants of KCNA1 (Montrer KCNA1 Kits ELISA), KCNA2, and KCNV2 (Montrer KCNV2 Kits ELISA) genes and risk or drug resistance of genetic generalized epilepsies after a Bonferroni correction for multiple comparisons.

  2. In the asymptomatic mother, the mutated copy of the CDKL5 (Montrer CDKL5 Kits ELISA) gene was inactivated in 90% of blood cells. We also identified a premature stop codon (p.Arg926*) in IQSEC2 (Montrer IQSEC2 Kits ELISA) in a patient with a Rett-like phenotype. Finally, exome sequencing enabled us to characterize a heterozygous de novo missense (p.Val408Ala) in KCNA2 in a girl with infantile-onset seizures variant of Rett syndrome (RTT)

  3. Novel recurrent missense mutation within the Kv1.2 voltage sensor associated with variable phenotypes, including hereditary spastic paraplegia, ataxia (Montrer USP14 Kits ELISA), and intellectual disability.

  4. This study demonstrated that KCNA2 mutation causes episodic ataxia (Montrer USP14 Kits ELISA) and pharmacoresponsive epilepsy.

  5. Use-dependent activation of Kv1.2 channels is mediated by an extrinsic regulator that binds preferentially to the channel closed state, with Thr252 being necessary but not sufficient for this interaction to alter channel function.

  6. This gene has not been previously described as a cause of disease in humans, but mutations of the orthologous gene in mice (Kcna2) are known to cause both ataxia (Montrer USP14 Kits ELISA) and convulsions

  7. KCNA2 is a new gene involved in human neurodevelopmental disorders through two different mechanisms, predicting either hyperexcitability or electrical silencing of KV1.2-expressing neurons.

  8. the inhibition of two K(+) channel (Montrer KCNC4 Kits ELISA) isoforms, Kv1.2 and KCa3.1 (Montrer KCNN4 Kits ELISA), by two drug molecules, lidocaine and TRAM (Montrer TRAM1 Kits ELISA)-34, is examined in atomic detail using molecular dynamics simulations.

  9. isoform betaII plays a central role in the PKC-dependent regulation of Kv1.5 (Montrer KCNA5 Kits ELISA)/Kvbeta1.2 channels.

  10. Using mutagenesis and analysis of gating currents from gating pore mutations in the Shaker Kv channel, we identified statistically highly significant correlations between VSD function and physicochemical properties of gating pore residues.

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) interaction partners

  1. Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 (Montrer CA3 Kits ELISA) pyramidal cells

  2. analysis of fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics

  3. This study showed that MK2 kinase is activated by TcdA and TcdB and regulates the expression of proinflammatory cytokines.

  4. Mk2 homozygous deletion in mice impedes the induction of experimental colitis by dextran sodium sulfate, confirming the notion that p38 (Montrer CRK Kits ELISA)/Mk2 is involved in this inflammatory response.

  5. The dynamic Sig-1R (Montrer SIGMAR1 Kits ELISA)-Kv1.2 complex represents a mechanism that shapes neuronal and behavioral response to cocaine.

  6. Overlapping patterns with differential expression and precise localization of Kv1.1 and Kv1.2 channels targeted to specialized subcellular compartments contribute to distinctive patterns of neuronal excitability --REVIEW

  7. the contribution of Kv1.2 in the regulation of nigrostriatal DA release by the D2-AR and thereby offer a novel mechanism by which DA release is regulated.

  8. These results suggest that independent of known mutations in Kcna1 (Montrer KCNA1 Kits ELISA) encoding Kv1.1, Kcna2 mutations may be important molecular correlates underlying human cerebellar ataxic disease.

  9. Data show that PSD-95 (Montrer DLG4 Kits ELISA) colocalizes precisely with Kv1 (Montrer KCNA5 Kits ELISA) potassium channels and Caspr2 (Montrer CNTNAP2 Kits ELISA) at juxtaparanodes, and that a macromolecular complex of Kv1 (Montrer KCNA5 Kits ELISA) channels and PSD-95 (Montrer DLG4 Kits ELISA) can be immunopurified from mammalian brain and spinal cord.

  10. Kcna2-null mice exhibited increased seizure susceptibility but, in contrast to Kcna1 (Montrer KCNA1 Kits ELISA)-null mice, hypoexcitability and enlarged Kv1 (Montrer KCNA5 Kits ELISA) currents in auditory neurons.

Xenopus laevis Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) interaction partners

  1. When mapped onto the X-ray structure of the K(v)1.2 channel the large number of permissive mutations support the notion of relatively independent domains, consistent with crystallographic studies

Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) profil antigène

Antigen Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Gene names and symbols associated with KCNA2

  • potassium voltage-gated channel, shaker-related subfamily, member 2 (KCNA2) anticorps
  • potassium voltage-gated channel, shaker-related subfamily, member 2 (TGas050c02.1) anticorps
  • potassium voltage-gated channel, shaker-related subfamily, member 2 (Kcna2) anticorps
  • potassium voltage-gated channel, shaker-related subfamily, member 2 (kcna2) anticorps
  • Akr6a4 anticorps
  • BK2 anticorps
  • ENSMUSG00000074335 anticorps
  • Gm10672 anticorps
  • HBK5 anticorps
  • HK4 anticorps
  • HUKIV anticorps
  • k(v)1.2 anticorps
  • Kca1-2 anticorps
  • kcna2 anticorps
  • kcna2-a anticorps
  • kv1.2 anticorps
  • Mk-2 anticorps
  • MK2 anticorps
  • NGK1 anticorps
  • RBK2 anticorps
  • XSha2 anticorps

Protein level used designations for KCNA2

potassium voltage-gated channel, shaker-related subfamily, member 2 , potassium voltage-gated channel subfamily A member 2-like , potassium voltage-gated channel subfamily A member 2 , voltage-gated potassium channel Kv1.2 , shaker subfamily potassium channel Kv1.2 alpha subunit , voltage-gated K(+) channel HuKIV , voltage-gated potassium channel HBK5 , voltage-gated potassium channel protein Kv1.2 , voltage-gated potassium channel subunit Kv1.2 , MK2 , Potassium (K+) channel protein alpha 2, voltage dependent , RAK , RBK2 , RCK5 , potassium voltage gated channel shaker related subfamily member 2 , Kv1.2' potassium channel , Voltage-gated potassium channel subunit Kv1.2 , potassium voltage-gated channel, shaker-related subfamily, member 2 a , CSMK1 , delayed rectifier K+ channel , voltage-dependent K channel , voltage-gated channel, shaker-related subfamily, member 2 , potassium channel (BGK5)

GENE ID SPECIES
469413 Pan troglodytes
702126 Macaca mulatta
100076742 Ornithorhynchus anatinus
100145813 Xenopus (Silurana) tropicalis
100444529 Pongo abelii
100478109 Ailuropoda melanoleuca
100596531 Nomascus leucogenys
395117 Gallus gallus
3737 Homo sapiens
16490 Mus musculus
25468 Rattus norvegicus
100537815 Danio rerio
373840 Xenopus laevis
404022 Canis lupus familiaris
397292 Sus scrofa
539608 Bos taurus
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