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anti-Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Anticorps

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. De plus, nous expédions PCSK9 Kits (65) et PCSK9 Protéines (61) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996
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Top anti-PCSK9 Anticorps sur anticorps-enligne.fr

Showing 10 out of 154 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Chèvre Inconjugué IHC (p), WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Chèvre Inconjugué EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with AP22408PU-N (1 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22408PU-N (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 8 to 10 Days
385,00 €
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of PCSK9 Antibody (N-term) in Jurkat cell line lysates (35ug/lane). PCSK9 (arrow) was detected using the purified Pab. 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué FACS, IHC (p), WB Western blot analysis of PCSK9 antibody (C-term) (ABIN391505) in Hela cell line lysates (35 µg/lane). PCSK9 (arrow) was detected using the purified polyclonal antibody. PCSK9 Antibody (C-term) (ABIN391505) IHC analysis in formalin fixed and paraffin embedded human Colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué FACS, IHC (p), WB Western blot analysis of PCSK9 Antibody (N-term) (ABIN652320) in Jurkat cell line lysates (35 µg/lane). PCSK9 (arrow) was detected using the purified polyclonal antibody. PCSK9 Antibody (N-term) (ABIN652320) IHC analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Chèvre Inconjugué EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with AP22407PU-N (0.5 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22407PU-N(1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 8 to 10 Days
385,00 €
Détails
Humain Chèvre Inconjugué IHC, ELISA, WB ABIN185371 staining (0.2 µg/mL) of McA cell lysates: untransfected (1), transfected with wild type human pcsk9 (2), transfected with S127R human pcsk9 (3). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London. ABIN185371 (0.3 µg/mL) staining of Human Adipose lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 3 to 4 Days
349,82 €
Détails
Humain Lapin Inconjugué WB   0.1 mg Connectez-vous pour afficher 8 to 10 Days
462,00 €
Détails
Humain Chèvre Inconjugué ChIP, IHC (p), IHC, ELISA, WB Western Blot: PCSK9 Antibody [ABIN268772] - Analysis of PCSK9 in McA cell lysates: untransfected (1), transfected with wild type human PCSK9 (2), transfected with S127R human PCSK9 (3) using ABIN268772 (0.2ug/ml). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London. Western Blot: PCSK9 Antibody [ABIN268772] - (0.3ug/ml) staining of Human Adipose lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 3 to 5 Days
426,25 €
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti-NARC1 Polyclonal Antibody, Unconjugated (ABIN761831) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Connectez-vous pour afficher 5 to 7 Days
315,94 €
Détails

PCSK9 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-PCSK9 Anticorps mieux référencés

  1. Human Polyclonal PCSK9 Primary Antibody pour ChIP, IHC (p) - ABIN268772 : Cohen, Pertsemlidis, Kotowski, Graham, Garcia, Hobbs: Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. dans Nature genetics 2005 (PubMed)
    Show all 9 references for ABIN268772

  2. Human Polyclonal PCSK9 Primary Antibody pour WB - ABIN493159 : Yue, Averna, Lin, Schonfeld: The c.43_44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population. dans Human mutation 2006 (PubMed)
    Show all 4 references for ABIN493159

  3. Human Polyclonal PCSK9 Primary Antibody pour IHC (p), WB - ABIN374535 : Lambert, Ancellin, Charlton, Comas, Pilot, Keech, Patel, Sullivan, Cohn, Rye, Barter: Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment. dans Clinical chemistry 2008 (PubMed)
    Show all 3 references for ABIN374535

  4. Human Polyclonal PCSK9 Primary Antibody pour EIA, WB - ABIN453778 : McNutt, Kwon, Chen, Chen, Horton, Lagace: Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. dans The Journal of biological chemistry 2009 (PubMed)
    Show all 3 references for ABIN453778

  5. Human Polyclonal PCSK9 Primary Antibody pour IHC, ELISA - ABIN185371 : Lalanne, Lambert, Amar, Chétiveaux, Zaïr, Jarnoux, Ouguerram, Friburg, Seidah, Brewer, Krempf, Costet: Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. dans Journal of lipid research 2005 (PubMed)
    Show all 2 references for ABIN185371

  6. Human Polyclonal PCSK9 Primary Antibody pour FACS, IHC (p) - ABIN652320 : Shioji, Mannami, Kokubo, Inamoto, Takagi, Goto, Nonogi, Iwai: Genetic variants in PCSK9 affect the cholesterol level in Japanese. dans Journal of human genetics 2004 (PubMed)
    Show all 2 references for ABIN652320

  7. Human Polyclonal PCSK9 Primary Antibody pour FACS, IHC (p) - ABIN391505 : Abifadel, Varret, Rabès, Allard, Ouguerram, Devillers, Cruaud, Benjannet, Wickham, Erlich, Derré, Villéger, Farnier, Beucler, Bruckert, Chambaz, Chanu, Lecerf, Luc, Moulin, Weissenbach, Prat, Krempf et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. ... dans Nature genetics 2003 (PubMed)
    Show all 2 references for ABIN391505

  8. Human Polyclonal PCSK9 Primary Antibody pour IF (p), IHC (p) - ABIN761831 : Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. dans Molecular medicine reports 2016 (PubMed)

  9. Human Polyclonal PCSK9 Primary Antibody pour EIA, WB - ABIN569616 : Kwon, Lagace, McNutt, Horton, Deisenhofer: Molecular basis for LDL receptor recognition by PCSK9. dans Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

Plus d’anticorps contre PCSK9 partenaires d’interaction

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. Data from this cross sectional study in a small sample of patients showed that plasma PCSK9 was correlated with the presence of calcific aortic valve disease but not its severity.

  2. Serum PCSK9 levels were found lower in intrauterine growth restriction only in male neonates born before 34 weeks of gestation.

  3. PCSK9 levels are linearly associated with the fraction and amount of necrotic core tissue in coronary atherosclerosis, independently of serum LDL cholesterol levels and statin use

  4. Both PCSK9 levels and CETP (Montrer CETP Anticorps) activity were higher in patients with an increasing number of metabolic syndrome components

  5. Circulating PCSK9 levels were correlated with an atherogenic lipid profile and with insulin (Montrer INS Anticorps) resistance parameters; The rs11591147 genetic variant of PCSK9 resulted in lower levels of circulating PCSK9 and LDL cholesterol

  6. PCSK9 increases hepatic lipid and lipoprotein production via apoE (Montrer APOE Anticorps)- and LDLR (Montrer LDLR Anticorps)-dependent mechanisms

  7. Possible inter-locus interactions among the DOCK7 (Montrer DOCK7 Anticorps), PCSK9 and GALNT2 (Montrer GALNT2 Anticorps) SNPs were also noted.

  8. In this study, variants in PCSK9 had approximately the same effect as variants in HMGCR (Montrer HMGCR Anticorps) on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive.

  9. During sepsis, PCSK9 levels are highly correlated with the development of subsequent multiple organ failure. Inhibition of PCSK9 activity is an attractive target for treating the spectrum of sepsis and septic shock.

  10. Report increased intestinal cholesterol absorption and elevated serum cholesterol in families with primary hypercholesterolemia without mutations in PCSK9.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. PCSK9 increases hepatic lipid and lipoprotein production via apoE (Montrer APOE Anticorps)- and LDLR (Montrer LDLR Anticorps)-dependent mechanisms

  2. Podocyte damage triggers marked inductions in plasma PCSK9, and knockout of Pcsk9 ameliorates dyslipidemia in a mouse model of nephrotic syndrome.

  3. polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating PCSK9.

  4. binding of PCSK9 to GRP94 (Montrer HSP90B1 Anticorps) protects LDLR (Montrer LDLR Anticorps) from degradation likely by preventing early binding of PCSK9 to LDLR (Montrer LDLR Anticorps)

  5. The absence of PCSK9 results in a sex- and tissue-specific subcellular distribution of the LDLR (Montrer LDLR Anticorps) and VLDLR (Montrer VLDLR Anticorps), which is determined by estradiol levels.

  6. that ox-LDL receptor-1 (Montrer OLR1 Anticorps) and PCSK9 positively influence each other's expression, especially during an inflammatory reaction

  7. Data show that leptin (Montrer LEP Anticorps) treatment suppresses proprotein convertase subtilisin/kexin type 9 (PCSK9) in male, but fails to suppress PCSK9 in female.

  8. The Liver Clock Controls Cholesterol Homeostasis through Trib1 (Montrer TRIB1 Anticorps) Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR (Montrer LDLR Anticorps)) Axis.

  9. Hepatic LDLR (Montrer LDLR Anticorps) levels are up-regulated in SEC24A (Montrer SEC24A Anticorps)-deficient cells as a consequence of specific dependence of PCSK9, a negative regulator of LDLR (Montrer LDLR Anticorps), on SEC24A (Montrer SEC24A Anticorps) for efficient exit from the ensoplasmic reticulum.

  10. PCSK9(-/-) mice display normal sodium balance and blood pressure regulation despite an increase of cleaved alphaENaC (Montrer SCNN1A Anticorps) under basal condition

PCSK9 profil antigène

Profil protéine

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Gene names and symbols associated with PCSK9

  • proprotein convertase subtilisin/kexin type 9 (pcsk9) anticorps
  • proprotein convertase subtilisin/kexin type 9 (PCSK9) anticorps
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9) anticorps
  • proprotein convertase subtilisin/kexin type 9-like (LOC100620501) anticorps
  • AI415265 anticorps
  • AI747682 anticorps
  • FH3 anticorps
  • HCHOLA3 anticorps
  • LDLCQ1 anticorps
  • NARC-1 anticorps
  • Narc1 anticorps
  • PC9 anticorps

Protein level used designations for PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPECIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
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