anti-Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Anticorps

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. De plus, nous expédions PCSK9 Kits (72) et PCSK9 Protéines (60) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996
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Top anti-PCSK9 Anticorps sur anticorps-enligne.fr

Showing 10 out of 155 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Chèvre Inconjugué EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with AP22408PU-N (1 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22408PU-N (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 8 to 10 Days
385,00 €
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of PCSK9 Antibody (N-term) in Jurkat cell line lysates (35ug/lane). PCSK9 (arrow) was detected using the purified Pab. 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué FACS, IHC (p), WB Western blot analysis of PCSK9 antibody (C-term) (ABIN391505) in Hela cell line lysates (35 µg/lane). PCSK9 (arrow) was detected using the purified polyclonal antibody. PCSK9 Antibody (C-term) (ABIN391505) IHC analysis in formalin fixed and paraffin embedded human Colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué FACS, IHC (p), WB Western blot analysis of PCSK9 Antibody (N-term) (ABIN652320) in Jurkat cell line lysates (35 µg/lane). PCSK9 (arrow) was detected using the purified polyclonal antibody. PCSK9 Antibody (N-term) (ABIN652320) IHC analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Chèvre Inconjugué EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with AP22407PU-N (0.5 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22407PU-N(1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 8 to 10 Days
385,00 €
Détails
Humain Chèvre Inconjugué IHC, ELISA, WB ABIN185371 staining (0.2 µg/mL) of McA cell lysates: untransfected (1), transfected with wild type human pcsk9 (2), transfected with S127R human pcsk9 (3). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London. ABIN185371 (0.3 µg/mL) staining of Human Adipose lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 3 to 4 Days
349,82 €
Détails
Humain Chèvre Inconjugué ChIP, IHC (p), IHC, ELISA, WB Western Blot: PCSK9 Antibody [ABIN268772] - Analysis of PCSK9 in McA cell lysates: untransfected (1), transfected with wild type human PCSK9 (2), transfected with S127R human PCSK9 (3) using ABIN268772 (0.2ug/ml). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London. Western Blot: PCSK9 Antibody [ABIN268772] - (0.3ug/ml) staining of Human Adipose lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 3 to 5 Days
426,25 €
Détails
Humain Lapin Inconjugué IHC (p), WB Anti-PCSK9 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Connectez-vous pour afficher 8 to 11 Days
298,57 €
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti-NARC1 Polyclonal Antibody, Unconjugated (ABIN761831) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Connectez-vous pour afficher 9 to 12 Days
315,94 €
Détails
Humain Chèvre Inconjugué IHC (p), WB   0.1 mg Connectez-vous pour afficher 6 to 8 Days
357,50 €
Détails

PCSK9 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-PCSK9 Anticorps mieux référencés

  1. Human Polyclonal PCSK9 Primary Antibody pour ChIP, IHC (p) - ABIN268772 : Cohen, Pertsemlidis, Kotowski, Graham, Garcia, Hobbs: Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. dans Nature genetics 2005 (PubMed)
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  2. Human Polyclonal PCSK9 Primary Antibody pour EIA, WB - ABIN453778 : McNutt, Kwon, Chen, Chen, Horton, Lagace: Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. dans The Journal of biological chemistry 2009 (PubMed)
    Show all 3 references for 453778

  3. Human Polyclonal PCSK9 Primary Antibody pour IHC, ELISA - ABIN185371 : Lalanne, Lambert, Amar, Chétiveaux, Zaïr, Jarnoux, Ouguerram, Friburg, Seidah, Brewer, Krempf, Costet: Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. dans Journal of lipid research 2005 (PubMed)
    Show all 2 references for 185371

  4. Human Polyclonal PCSK9 Primary Antibody pour FACS, IHC (p) - ABIN391505 : Shioji, Mannami, Kokubo, Inamoto, Takagi, Goto, Nonogi, Iwai: Genetic variants in PCSK9 affect the cholesterol level in Japanese. dans Journal of human genetics 2004 (PubMed)
    Show all 2 references for 391505

  5. Human Polyclonal PCSK9 Primary Antibody pour FACS, IHC (p) - ABIN652320 : Abifadel, Varret, Rabès, Allard, Ouguerram, Devillers, Cruaud, Benjannet, Wickham, Erlich, Derré, Villéger, Farnier, Beucler, Bruckert, Chambaz, Chanu, Lecerf, Luc, Moulin, Weissenbach, Prat, Krempf et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. ... dans Nature genetics 2003 (PubMed)
    Show all 2 references for 652320

  6. Human Polyclonal PCSK9 Primary Antibody pour IF (p), IHC (p) - ABIN761831 : Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. dans Molecular medicine reports 2016 (PubMed)

  7. Human Polyclonal PCSK9 Primary Antibody pour EIA, WB - ABIN569616 : Kwon, Lagace, McNutt, Horton, Deisenhofer: Molecular basis for LDL receptor recognition by PCSK9. dans Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

Plus d’anticorps contre PCSK9 partenaires d’interaction

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. Use Crispr-Cas (Montrer CSE1L Anticorps) system to introduce nonsense variants into PCSK9 to lower blood cholesterol levels.

  2. PCSK9 decreased in youth participating in an intensive dietary intervention. Change in HOMA-IR was associated with change in PCSK9, independent of weight loss, suggesting an important relationship with insulin (Montrer INS Anticorps) sensitivity.

  3. these studies support that reductions in Lp(a (Montrer APOA Anticorps)) with PCSK9 inhibition are partly due to increased LDLR (Montrer LDLR Anticorps)-mediated uptake. In most situations, Lp(a (Montrer APOA Anticorps)) appears to compete poorly with LDL for LDLR (Montrer LDLR Anticorps) binding and internalization, but when LDLR (Montrer LDLR Anticorps) expression is increased with evolocumab, particularly in the setting of low circulating LDL, Lp(a (Montrer APOA Anticorps)) is reduced.

  4. Plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9), apolipoprotein C-III (apoC3 (Montrer APOC3 Anticorps)) and small dense low density lipoprotein cholesterol (sdLDL-C) showed significant interactions with current dyslipidemias, and were predictive in the screening.

  5. Some loss of function variants in PCSK9 are associated with enhanced LDL cholesterol lowering response to statin therapy.

  6. These observations suggest positive feedback interplay between SMC (Montrer DYM Anticorps)-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS. This interaction results in cellular injury, characterized by apoptosis-a hallmark of atherosclerosis.

  7. PCSK9 level is not associated with systolic or diastolic blood pressure in hypertensives or normotensives, but it positively correlates with carotid intima-media thickness in hypertensives in univariate but not multivariate analyses, and further researches are needed.

  8. results reveal that the tanshinone IIA modulates LDLR (Montrer LDLR Anticorps) level and activity via down-regulation of PCSK9 expression in hepatic cells

  9. This article reviews the functions and regulatory mechanisms of PCSK9. The effects of PCSK9 on the LDL receptor (Montrer LDLR Anticorps), the relationship of this convertase with IDOL (Montrer MYLIP Anticorps), and treatments currently available against hypercholesterolemia are also discussed. [review]

  10. LC n-3 PUFA intake is associated with a lower risk of nonfatal MI in C-allele carriers of PCSK9 rs11206510 (n = 799) but not in non-C-allele carriers (n = 3188).

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. Use Crispr-Cas (Montrer CTNND1 Anticorps) system to introduce nonsense variants into PCSK9 to lower blood cholesterol levels.

  2. Studied the combination model of a single AAV-PCSK9 injection, high-fat diet, and partial carotid ligation which induces robust atherosclerosis in the flow-disturbed carotid artery within 3 weeks in C57 mice, and results suggest this is a quick and convenient model to study atherosclerosis and mechanisms using any knockout or transgenic mice without having to generate double knockouts.

  3. These observations suggest positive feedback interplay between SMC (Montrer DYM Anticorps)-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS. This interaction results in cellular injury, characterized by apoptosis-a hallmark of atherosclerosis.

  4. AdipoR activation by agonists regulated PCSK9 expression and inhibits atherosclerosis in apoE (Montrer APOE Anticorps)(-/-) mice.

  5. Adeno (Montrer ADORA2A Anticorps)-associated virus mediated infection with a mouse PCSK9 gain-of-function mutation is a rapid, easy, and efficient approach for inducing hypercholesterolemia and promoting abdominal aortic aneurysms in C57BL/6 mice infused with angiotensin II.

  6. conditions that cause ER stress regardless of their ability to dysregulate ER Ca(2 (Montrer CA2 Anticorps)+) inhibit PCSK9 secretion, thereby reducing PCSK9-mediated LDLR (Montrer LDLR Anticorps) degradation and promoting LDLR (Montrer LDLR Anticorps)-dependent hepatic cholesterol uptake.

  7. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor (Montrer LDLR Anticorps) Degradation.

  8. PCSK9 increases hepatic lipid and lipoprotein production via apoE (Montrer APOE Anticorps)- and LDLR (Montrer LDLR Anticorps)-dependent mechanisms

  9. Podocyte damage triggers marked inductions in plasma PCSK9, and knockout of Pcsk9 ameliorates dyslipidemia in a mouse model of nephrotic syndrome.

  10. polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating PCSK9.

PCSK9 profil antigène

Profil protéine

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Gene names and symbols associated with PCSK9

  • proprotein convertase subtilisin/kexin type 9 (pcsk9) anticorps
  • proprotein convertase subtilisin/kexin type 9 (PCSK9) anticorps
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9) anticorps
  • proprotein convertase subtilisin/kexin type 9-like (LOC100620501) anticorps
  • AI415265 anticorps
  • AI747682 anticorps
  • FH3 anticorps
  • HCHOLA3 anticorps
  • LDLCQ1 anticorps
  • NARC-1 anticorps
  • Narc1 anticorps
  • PC9 anticorps

Protein level used designations for PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPECIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
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