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The protein encoded by PKD2 belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. De plus, nous expédions PKD2 Kits (11) et PKD2 Protéines (11) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 125 products:
Human Polyclonal PKD2 Primary Antibody pour IP, WB - ABIN152061
Liu, Evans, Britton, Zachary: The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis. dans Oncogene 2008
Show all 8 references for ABIN152061
Human Polyclonal PKD2 Primary Antibody pour EIA, IHC (p) - ABIN360330
Stayner, Zhou: Polycystin channels and kidney disease. dans Trends in pharmacological sciences 2001
Show all 5 references for ABIN360330
Novel PKD2 mutations in Chinese autosomal dominant polycystic kidney disease patients
Two neutral missense PKD2 variants indentified in exon1 c.83G>C (p.R28P) and c.568G>A (p.A190T), which the former segregate with the mutation in affected relatives, and two new intronic and 3'UTR (Montrer UTS2R Anticorps) variants, c.1548+63C>T and c.*363delA.
this study presents the cryo-EM structure of PKD2 in lipid bilayers at 3.0 A resolution, which establishes PKD2 as a homotetrameric ion channel and provides insight into potential mechanisms for its activation.
PCs expression and p53 (Montrer TP53 Anticorps) activation as a regulator of cell proliferation were further evaluated in vivo and in 69 advanced human carotid atherosclerotic plaques.
PKD2 and RSK1 (Montrer RPS6KA1 Anticorps) regulate integrin beta4 phosphorylation at threonine 1736 to stabilize keratinocyte cell adhesion and its hemidesmosomes.
The coiled-coil domain in the PC2 (Montrer KRT6B Anticorps) C-terminal forms a stable helix bundle regardless of the presence of Ca(2 (Montrer CA2 Anticorps)+).
Results show that some of the previously reported missense or synonymous mutations in PKD2 gene caused altered pre-mRNA splicing.
PKD2 is a core factor in the formation of this multiprotein complex at the TGN (Montrer TG Anticorps) that controls constitutive secretion of matrix metalloproteinase (Montrer MMP20 Anticorps) cargo.
Human polycystin-2 transgene dose-dependently rescues autosomal-dominant polycystic kidney disease phenotypes in Pkd2 mutant mice
FLNA (Montrer FLNA Anticorps) anchors PC2 (Montrer KRT6B Anticorps) to the actin cytoskeleton through complex PC2 (Montrer KRT6B Anticorps)-FLNA (Montrer FLNA Anticorps)-actin to reduce degradation and increase stability, and possibly regulate PC2 (Montrer KRT6B Anticorps) function in a Ca-dependent manner.
Our studies demonstrate that PKD1 (Montrer PKD1 Anticorps)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (Montrer DGKA Anticorps) effect on MVB secretory traffic.
Results reveal that whereas protein kinase D1 (Montrer PRKD1 Anticorps) and protein kinase D2 are essential for neuronal polarity, there exists a functional redundancy between the two proteins.
PKD2 acted as an amplification checkpoint for antigen-stimulated digital cytokine responses and translated the differential strength of TCR signaling to determine the number of naive CD8 (Montrer CD8A Anticorps)(+) T cells that became effector cells.
Protein kinase D2 promotes in vitro osteoclast differentiation and fusion
A bioinformatic screen identified the serine-threonine kinase (Montrer CDK4 Anticorps) protein kinase D2 (PRKD2) as a potential effector of GABP in hematopoietic stem cells
Transcriptional profiling reveals the full consequences of PKD2 loss and maps in detail the selective, but critical, function for PKD2 in signalling by alpha/beta mature TCR complexes in peripheral T-cells.
PKD2 is a common signaling target downstream of various agonist receptors in platelets and G(q)-mediated signals along with calcium and novel PKC (Montrer PKC Anticorps) isoforms, in particular, PKCdelta (Montrer PKCd Anticorps) activate PKD2 in platelets.
Data demonstrate that, unlike PKD1 (Montrer PKD1 Anticorps), PKD2 catalytic activity is dispensable for normal embryogenesis.
PKD2, like PKD (Montrer PRKD1 Anticorps), facilitates mitogenesis in 3T3 cells
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein kinase D2
, serine/threonine-protein kinase D2-like
, autosomal dominant polycystic kidney disease type II protein
, transient receptor potential cation channel, subfamily P, member 2
, serine/threonine-protein kinase D2