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PPP4R1 encodes one of several alternate regulatory subunits of serine\\/threonine protein phosphatase 4 (PP4). De plus, nous expédions Protein Phosphatase 4, Regulatory Subunit 1 Anticorps (19) et Protein Phosphatase 4, Regulatory Subunit 1 Protéines (4) et beaucoup plus de produits pour cette protéine.
PP4R1 could mediate the dephosphorylation of TRAF2 (Montrer TRAF2 Kits ELISA) Ser11.
PP4R1 expression was triggered upon activation and proliferation of primary human T lymphocytes and deficiency for PP4R1 caused sustained and increased IKK (Montrer CHUK Kits ELISA) activity, T cell hyperactivation, and aberrant NF-kappaB (Montrer NFKB1 Kits ELISA) signaling in NF-kappaB (Montrer NFKB1 Kits ELISA)-addicted T cell lymphomas
LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function.
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.
protein phosphatase 4, regulatory subunit 1
, serine/threonine phosphatase 4
, serine/threonine-protein phosphatase 4 regulatory subunit 1