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The protein encoded by PTPRCAP was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC\\/CD45, a key regulator of T- and B-lymphocyte activation. De plus, nous expédions Protein tyrosine Phosphatase, Receptor Type, C Polypeptide-Associated Protein Anticorps (30) et et beaucoup plus de produits pour cette protéine.
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The association of LPAP with CD45 (Montrer PTPRC Kits ELISA) is dispensable for CD45 (Montrer PTPRC Kits ELISA)-mediated apoptosis signaling, as shown in studies of LPAP knocked-out thymocytes.
results support a model in which binding of CD45-AP to inactive CD45 (Montrer PTPRC Kits ELISA) dimers converts them to active monomers
results support the model: following phorbol 12-myristate 13-acetate (PMA) or TCR/CD3 (Montrer CD3 Kits ELISA) activation of T cells, LPAP is rapidly dephosphorylated at Ser (Montrer SIGLEC1 Kits ELISA)-99 and Ser (Montrer SIGLEC1 Kits ELISA)-172 and slowly phosphorylated at Ser (Montrer SIGLEC1 Kits ELISA)-163. Ser (Montrer SIGLEC1 Kits ELISA)-153 exhibited a high basal level of phosphorylation in both resting and activated cells
Data show that the minor allele of rs869736 in the PTPRCAP promoter is associated with increased susceptibility to diffuse-type gastric cancer by increasing PTPRCAP expression.
We analysed the C77G polymorphism in multiple sclerosis (MS) patients from the genetically homogeneous population of Sardinia. CD45 (Montrer PTPRC Kits ELISA) did not contribute to development of the disease in Sardinian MS.
The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein.
, CD45-associated protein
, PTPRC-associated protein
, protein tyrosine phosphatase receptor type C-associated protein
, CD45 associated protein
, lymphocyte phosphatase-associated phosphoprotein
, protein tyrosine phosphatase, receptor type, c polypeptide-associated protein
, protein tyrosine phosphatase, receptor type, C polypeptide-associated protein