Protein-O-Mannosyltransferase 1 Protéines (POMT1)

The protein encoded by POMT1 is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. De plus, nous expédions Protein-O-Mannosyltransferase 1 Anticorps (52) et Protein-O-Mannosyltransferase 1 Kits (7) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
POMT1 10585 Q9Y6A1
POMT1 99011 Q8R2R1
Rat POMT1 POMT1 84430 Q99PR0
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Showing 6 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 60 to 65 Days
$8,623.45
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 60 to 65 Days
$6,052.17
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$405.71
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Escherichia coli (E. coli) Humain T7 tag,His tag   100 μg Connectez-vous pour afficher 15 to 18 Days
$650.00
Détails
Escherichia coli (E. coli) Souris T7 tag,His tag   100 μg Connectez-vous pour afficher 15 to 18 Days
$704.00
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Escherichia coli (E. coli) Humain Inconjugué   5 applications Connectez-vous pour afficher 1 to 2 Days
$312.71
Détails

POMT1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine) ,
,

Plus protéines pour Protein-O-Mannosyltransferase 1 (POMT1) partenaires d'interaction

Human Protein-O-Mannosyltransferase 1 (POMT1) interaction partners

  1. O-mannosylation of cadherins and protocadherins does not require POMT1 and/or POMT2 (Montrer POMT2 Protéines) in contrast to alpha-dystroglycan, and moreover, the O-Man glycans on cadherins are not elongated.

  2. results demonstrate functional and biochemical similarities between POMT1 and its orthologue from bakers' yeast Pmt4.

  3. Our results suggest that POMT activity is inversely proportional to clinical severity, and demonstrate that skin fibroblasts can be used for differential diagnosis of patients with alpha-dystroglycanopathies. We have provided clinical, histological, enzymatic and genetic evidence of POMT1 involvement in five unrelated Chinese patients.

  4. Inhibition of POMT1/2 in human mesencyhmal stem cells , resulted in complete abolishment of chondrogenesis and alterations of adipogenic and osteogenic potential together with a lethal effect during myogenic induction.

  5. Three patients with heterozygous POMT1 mutations showed left ventricular (LV) dilation and/or decrease in myocardial contractile force.

  6. the effects of replacing Arg(64), Glu (Montrer DCTN1 Protéines)(78) and Arg(138)residues in human POMT1 and POMT2 (Montrer POMT2 Protéines) with Ala on complex formation and enzymatic activity were studied.

  7. the function of the gene products is only known for POMT1, POMT2 (Montrer POMT2 Protéines), and POMGnT1 (Montrer POMGNT1 Protéines), all responsible for the O-mannosylglycan biosynthesis

  8. the N-glycosylation of POMT1 and POMT2 (Montrer POMT2 Protéines) is required for maintaining the conformation as well as the activity of the POMT1-POMT2 (Montrer POMT2 Protéines) complex.

  9. Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker-Warburg syndrome

  10. Extracellular matrix and nuclear abnormalities in skeletal muscle of a patient with Walker-Warburg syndrome caused by POMT1 mutation.

Mouse (Murine) Protein-O-Mannosyltransferase 1 (POMT1) interaction partners

  1. during embryogenesis, Pomt1 is expressed in the neural tube, the developing eye, and the mesenchyme; targeted deletion of Pomt1 results in early embryonic lethality due to defects in the assembly of Reichert's membrane

Profil protéine Protein-O-Mannosyltransferase 1 (POMT1)

Profil protéine

The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K). Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with POMT1

  • protein O-mannosyltransferase 1 (POMT1)
  • protein-O-mannosyltransferase 1 (Pomt1)
  • AI505244 Protéine
  • LGMD2K Protéine
  • MDDGA1 Protéine
  • MDDGB1 Protéine
  • MDDGC1 Protéine
  • RT Protéine

Protein level used designations for POMT1

dolichyl-phosphate-mannose--protein mannosyltransferase 1 , dolichyl-phosphate-mannose-protein mannosyltransferase , protein O-mannosyl-transferase 1 , protein O-mannosyltransferase 1

GENE ID SPECIES
10585 Homo sapiens
617609 Bos taurus
99011 Mus musculus
84430 Rattus norvegicus
608039 Canis lupus familiaris
100525803 Sus scrofa
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