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anti-Pyruvate Dehydrogenase Complex, Component X (PDHX) Anticorps

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. De plus, nous expédions Pyruvate Dehydrogenase Complex, Component X Protéines (7) et Pyruvate Dehydrogenase Complex, Component X Kits (1) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PDHX 8050 O00330
PDHX 27402 Q8BKZ9
PDHX 311254  
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Top anti-Pyruvate Dehydrogenase Complex, Component X Anticorps sur anticorps-enligne.fr

Showing 10 out of 58 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué IF, IHC (p), WB Western blot analysis of anti-PDX1 Antibody (T11) (ABIN388774) in NCI-H460 cell line lysates (35 µg/lane).PDX1-T11(arrow) was detected using the purified polyclonal antibody. Western blot analysis of PDX1 (arrow) using PDX1 Antibody (T11) (ABIN388774). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PDX1 gene (Lane 2) (Origene Technologies). 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué WB The anti-PDX1 Pab (ABIN388773) is used in Western blot to detect PDX1 in mouse heart tissue lysate. Western blot analysis of PDX1 (arrow) using rabbit polyclonal PDX1 Antibody (C-term) (ABIN388773). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PDX1 gene (Lane 2) (Origene Technologies). 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Chèvre Inconjugué IHC, ELISA, WB ABIN185236 (1µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN185389 staining of paraffin embedded Human Pancreas. A) Microwaved antigen retrieval with citrate buffer pH 6 (3µg/ml), HRP-staining. B) Microwaved antigen retrieval with Tris/EDTA buffer pH9 (1µg/ml) , HRP-staining. 100 μg Connectez-vous pour afficher 3 to 4 Days
349,82 €
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Chèvre Inconjugué IHC (p), IHC, ELISA, WB ABIN250349 staining of paraffin embedded Human Pancreas. A) Microwaved antigen retrieval with citrate buffer pH 6 (3?g/ml), HRP-staining. B) Microwaved antigen retrieval with Tris/EDTA buffer pH9 (1?g/ml) , HRP-staining. Western Blot: PDHX Antibody [ABIN250349] - Western blot analysis of Human Pancreas lysate (35ug protein in RIPA buffer) using ABIN250349 (1ug/ml). 0.1 mg Connectez-vous pour afficher 3 to 5 Days
388,75 €
Détails
Humain Lapin Inconjugué EIA, WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Lapin Inconjugué WB WB Image Sample (30 ug of whole cell lysate) A: A431 , B: H1299 C: Hela 10% SDS PAGE antibody diluted at 1:1000 100 μL Connectez-vous pour afficher 5 to 7 Days
357,24 €
Détails
Humain Lapin Inconjugué IHC, WB 100 μL Connectez-vous pour afficher 12 Days
392,86 €
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of various cell lines, using PDHX antibody. Immunofluorescence analysis of U2OS cell using PDHX antibody. Blue: DAPI for nuclear staining. 100 μL Connectez-vous pour afficher 12 Days
261,90 €
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Western Blot: PDHX Antibody [NBP1-84079] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted).Lane 5: Human liver tissue.Lane 6: Human tonsil tissue Immunohistochemistry-Paraffin: PDHX Antibody [NBP1-84079] - Staining of human stomach shows strong cytoplasmic(granular pattern) and nuclear positivity in glandular cells. 0.1 mL Connectez-vous pour afficher 6 to 9 Days
418,75 €
Détails

PDHX Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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Mouse (Murine) ,
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anti-Pyruvate Dehydrogenase Complex, Component X Anticorps mieux référencés

  1. Human Polyclonal PDHX Primary Antibody pour EIA, WB - ABIN4620452 : Ling, McEachern, Seyda, MacKay, Scherer, Bratinova, Beatty, Giovannucci-Uzielli, Robinson: Detection of a homozygous four base pair deletion in the protein X gene in a case of pyruvate dehydrogenase complex deficiency. dans Human molecular genetics 1998 (PubMed)
    Show all 4 references for ABIN4620452

  2. Human Polyclonal PDHX Primary Antibody pour IF, IHC (p) - ABIN388774 : Aral, Benelli, Ait-Ghezala, Amessou, Fouque, Maunoury, Créau, Kamoun, Marsac: Mutations in PDX1, the human lipoyl-containing component X of the pyruvate dehydrogenase-complex gene on chromosome 11p1, in congenital lactic acidosis. dans American journal of human genetics 1998 (PubMed)
    Show all 3 references for ABIN388774

  3. Human Polyclonal PDHX Primary Antibody pour EIA, IHC (p) - ABIN4620453 : Murray, Gilkerson, Capaldi: Quantitative proteomics: the copy number of pyruvate dehydrogenase is more than 10(2)-fold lower than that of complex III in human mitochondria. dans FEBS letters 2002 (PubMed)
    Show all 3 references for ABIN4620453

  4. Human Polyclonal PDHX Primary Antibody pour WB - ABIN388773 : Harris, Bowker-Kinley, Wu, Jeng, Popov: Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex. dans The Journal of biological chemistry 1997 (PubMed)
    Show all 2 references for ABIN388773

  5. Human Polyclonal PDHX Primary Antibody pour IHC (p), IHC - ABIN250349 : Schild, Ruhs, Beiter, Zügel, Hudemann, Reimer, Krumholz-Wagner, Wagner, Keller, Eder, Krüger, Krüger, Braun, Nieß, Steinacker, Mooren: Basal and exercise induced label-free quantitative protein profiling of m. vastus lateralis in trained and untrained individuals. dans Journal of proteomics 2015 (PubMed)

  6. Human Polyclonal PDHX Primary Antibody pour IHC, ELISA - ABIN185389 : Roche, Baker, Yan, Hiromasa, Gong, Peng, Dong, Turkan, Kasten: Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. dans Progress in nucleic acid research and molecular biology 2001 (PubMed)

Plus d’anticorps contre Pyruvate Dehydrogenase Complex, Component X partenaires d’interaction

Human Pyruvate Dehydrogenase Complex, Component X (PDHX) interaction partners

  1. We propose testing for the R446* mutation in PDHX as a rapid first screening in Roma infants with metabolic acidosis.

  2. MiR (Montrer MLXIP Anticorps)-26a regulates glucose metabolism of colorectal cancer cells by direct targeting PDHX.

  3. New mutation in PDHX gene found in two unrelated patients with Pyruvate dehydrogenase (Montrer PDP Anticorps) deficiency.

  4. genetic association with systemic lupus erythematosus to a haplotype between PDHX and CD44 (Montrer CD44 Anticorps) was established.

  5. determination that PDH (Montrer PDP Anticorps) and complex III exist at a steady-state ratio of 1:100, 1:128 and 1:202 in HeLa cell extracts, fibroblast mitochondria and heart tissue mitochondria, respectively

  6. model of the pyruvate dehydrogenase (Montrer PDP Anticorps) complex formed by E2 and E2 plus the E3-binding protein and binding of the E1 and E3 components

  7. specificity of pairing for human E3BP with E3 from its subcomplex structure to be most likely due to conformational rigidity of the binding fragment of the E3-binding domain of E3BP and its exquisite amino acid match with the E3 target interface

  8. A cluster of disease-causing E3 mutations located near the center of the E3BD/E3 interface prevents the efficient recruitment of these E3 variants by E3BP into the PDC (Montrer PNKD Anticorps), leading to the dysfunction of the PDC (Montrer PNKD Anticorps) catalytic machine.

  9. These data provide an additional case of E3BP deficiency with a unique and previously unreported deletion in the PDHX gene.

  10. Despite the presence of antibodies reactive with PDC (Montrer PNKD Anticorps)-E3BP in the majority of primary biliary cirrhosis (PBC (Montrer DLAT Anticorps)) patients this self-protein is not a dominant T-cell autoantigen in PBC (Montrer DLAT Anticorps).

Mouse (Murine) Pyruvate Dehydrogenase Complex, Component X (PDHX) interaction partners

  1. T1a/podoplanin (Montrer PDPN Anticorps) is first expressed in prox 1 (Montrer PROX1 Anticorps)-positive lymphatic progenitor cells, with predominant localization in the luminal plasma membrane of lymphatic endothelial cells during later development.

  2. In islet cells both fat and glucose regulate PDK (Montrer PDK2 Anticorps) gene and protein expression and indicate that hyperglycemia and hyperlipidemia contribute to the decline in diabetic islet PDH (Montrer PDP Anticorps) activity by increasing mRNA and protein expression of PDK (Montrer PDK2 Anticorps).

Cow (Bovine) Pyruvate Dehydrogenase Complex, Component X (PDHX) interaction partners

  1. This study showed that the recombinant and bovine E2/E3BP cores bind E3s with a 2:1 stoichiometry, and propose that mammalian PDC (Montrer PDC Anticorps) comprises a heterogeneous population of assemblies incorporating a network of E3 cross-bridges above the core surface.

Pyruvate Dehydrogenase Complex, Component X (PDHX) profil antigène

Profil protéine

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit\; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with PDHX

  • pyruvate dehydrogenase complex, component X (pdhx) anticorps
  • pyruvate dehydrogenase complex, component X (PDHX) anticorps
  • E3-binding protein (pdhX) anticorps
  • pyruvate dehydrogenase complex, component X (LOC100220979) anticorps
  • pyruvate dehydrogenase complex, component X (LOC100349815) anticorps
  • pyruvate dehydrogenase complex, component X (Pdhx) anticorps
  • pyruvate dehydrogenase protein X component-like (LOC517402) anticorps
  • Ac1164 anticorps
  • AI481367 anticorps
  • DDBDRAFT_0168431 anticorps
  • DDBDRAFT_0230192 anticorps
  • DDB_0168431 anticorps
  • DDB_0230192 anticorps
  • DLDBP anticorps
  • E3bp anticorps
  • MGC86218 anticorps
  • OPDX anticorps
  • PDHX anticorps
  • Pdx1 anticorps
  • proX anticorps
  • zgc:66110 anticorps
  • zgc:85977 anticorps

Protein level used designations for PDHX

pyruvate dehydrogenase complex, component X , pyruvate dehydrogenase protein X component, mitochondrial-like , dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex , lipoyl-containing pyruvate dehydrogenase complex component X , pyruvate dehydrogenase complex, E3-binding protein subunit , pyruvate dehydrogenase complex, lipoyl-containing component X , pyruvate dehydrogenase protein X component, mitochondrial , dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex (E3-binding protein) (proX) , E3-binding protein , E3BP , proX , pyruvate dehydrogenase protein X component

GENE ID SPECIES
393532 Danio rerio
423154 Gallus gallus
447247 Xenopus laevis
451120 Pan troglodytes
8618072 Dictyostelium discoideum AX4
100059260 Equus caballus
100220979 Taeniopygia guttata
100349815 Oryctolagus cuniculus
100379696 Xenopus (Silurana) tropicalis
100455315 Pongo abelii
100475970 Ailuropoda melanoleuca
100544023 Meleagris gallopavo
100586539 Nomascus leucogenys
8050 Homo sapiens
27402 Mus musculus
311254 Rattus norvegicus
475942 Canis lupus familiaris
517402 Bos taurus
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