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RBM39 encodes a member of the U2AF65 family of proteins. De plus, nous expédions RBM39 Protéines (4) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal RBM39 Primary Antibody pour IP, WB - ABIN223403
Sotgia, Del Galdo, Casimiro, Bonuccelli, Mercier, Whitaker-Menezes, Daumer, Zhou, Wang, Katiyar, Xu, Bosco, Quong, Aronow, Witkiewicz, Minetti, Frank, Jimenez, Knudsen, Pestell, Lisanti: Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. dans The American journal of pathology 2009
Show all 2 Pubmed References
RBM39 is extensively involved in alternative splicing of RNA and helps regulate transcript levels. RBM39 may modulate alternative splicing similarly to U2AF65 (Montrer U2AF59 Anticorps) by either directly binding to RNA or recruiting other splicing factors, such as U2AF65 (Montrer U2AF59 Anticorps).
The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1 (Montrer TIA1 Anticorps), Pcbp1 (Montrer PCBP1 Anticorps), and RBM39 stabilizes or increases U2 snRNP (Montrer LSM2 Anticorps) recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39-mediated splicing regulation.
This study therefore establishes a structural basis for specific UHM-ULM interactions by splicing factors such as U2AF35 (Montrer U2AF1 Anticorps), U2AF65 (Montrer U2AF59 Anticorps), RBM39 and SF3b155 (Montrer SF3B1 Anticorps), and a platform for continued studies of intermolecular interactions governing disease-related alternative splicing in eukaryotic cells.
mammalian c-Abl (Montrer ABL1 Anticorps) plays an important role in steroid hormone receptor (Montrer NR4A1 Anticorps)-mediated transcription by regulating RBM39
Knockdown of CAPER expression markedly reduced human breast cancer cell proliferation in both in vitro and in vivo settings. Mechanistically, knockdown of CAPER abrogated the activity of proliferative and protein synthesis pathways.
identify SF3b155 (Montrer SF3B1 Anticorps) as the relevant ULM-containing partner of full-length CAPERalpha in human cell extracts.
Data show that CSE1L (Montrer CSE1L Anticorps), DIDO1 (Montrer DIDO1 Anticorps) and RBM39 mRNA expression levels correlated with chromosome 20q DNA copy number status.
Increased VEGF(165) expression is secondary to the down-regulation of CAPER-alpha by EWS/FLI-1. CAPER-alpha mediates alternative splicing and controls the shift from VEGF(189) to VEGF(165) .
this study identifies CAPERalpha (RNA binding motif protein 39) as a new transcriptional coregulator for v-Rel (Montrer NFkBP65 Anticorps) and reveals an important role in modulating Rel's oncogenic activity.
Analysis of human breast cancer samples revealed that CAPER is overexpressed and undergoes a cytoplasmic-to-nuclear shift during the transition from pre-malignancy to ductal carcinoma in situ
CAPER integrates mitochondrial energy metabolism by coactivating ERR-alpha (Montrer ESRRA Anticorps)-Gabpa (Montrer GABPA Anticorps) and stress-induced adaptive metabolic responses via NF- kappaB (Montrer NFKB1 Anticorps)/c-Myc (Montrer MYC Anticorps).
This gene encodes a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X.
RNA binding motif protein 39
, RNA binding motif protein 39, isoform 1
, RNA-binding protein 39
, RNA-binding protein 39-like
, RNA-binding region (RNP1, RRM) containing 2
, coactivator of activating protein-1 and estrogen receptors
, functional spliceosome-associated protein 59
, hepatocellular carcinoma protein 1
, splicing factor HCC1
, RNA-binding motif protein 39
, RNA-binding region-containing protein 2
, coactivator of AP-1 and ERs
, coactivator of activating protein 1 and estrogen receptors
, transcription coactivator CAPER