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RSPO3 encodes a member of the thrombospondin type 1 repeat supergene family. De plus, nous expédions R-Spondin 3 Protéines (14) et R-Spondin 3 Kits (9) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal RSPO3 Primary Antibody pour ELISA, WB - ABIN4240612
Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. dans Molecular medicine (Cambridge, Mass.) 2010
Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK (Montrer PTPRK Anticorps)(e1)-RSPO3(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT (Montrer WNT2 Anticorps) blockade by the porcupine (Montrer PORCN Anticorps) inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT (Montrer WNT2 Anticorps) pathway inhibitor AXIN1 (Montrer AXIN1 Anticorps), with consequent protein loss.
PTPRK (Montrer PTPRK Anticorps)-RSPO3 fusions and RNF43 (Montrer RNF43 Anticorps) mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs).
Using C-mannosylation-defective Rspo3 mutant-overexpressing cell lines, we found that C-mannosylation of Rspo3 promotes its secretion and activates Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling.
High RSPO3 expression is associated with breast cancer.
A genome-wide association study of bone mineral density (BMD (Montrer BEST1 Anticorps)) found a new BMD (Montrer BEST1 Anticorps) locus that harbors the PTCH1 (Montrer PTCH1 Anticorps) gene, that associates with reduced spine BMD (Montrer BEST1 Anticorps) and the RSPO3 associates with increased spine BMD (Montrer BEST1 Anticorps).
results suggest that the expression of RSPO (Montrer RSPO1 Anticorps) fusion transcripts is related to a subset of colorectal cancers arising in the Japanese population
These findings suggest that aberrant RSPO3-LGR4 (Montrer LGR4 Anticorps) signaling potentially acts as a driving mechanism in the aggressiveness of Keap1 (Montrer KEAP1 Anticorps)-deficient lung ADs (Montrer AGPS Anticorps).
using RNA-seq data, identification of multiple fusion transcripts including recurrent gene fusions involving R-spondin family members RSPO2 (Montrer RSPO2 Anticorps) and RSPO3 that together occur in 10% of colon tumours
the gene is a novel member of thrombospondin type I repeat supergene family (hPWTSR)
a polymorphism in thrombospondin subtly but significantly sensitizes the calcium-binding repeats to removal of Ca2 (Montrer CA2 Anticorps)+ and thermal denaturation
We provide in vivo evidence that RSPO3 stimulates the crypt stem cell and niche compartments and drives rapid intestinal tumorigenesis.
Rspo3 function remains essential in adult life to ensure replenishment of lost cells and maintain the properties of the zona glomerulosa
Conditional deletion of Rspo3 in mice disrupts activation of central fate, demonstrating its crucial role in determining and maintaining beta-catenin (Montrer CTNNB1 Anticorps)-dependent zonation.
data identify endothelial RSPO3-driven non-canonical WNT (Montrer WNT2 Anticorps)/Ca(2 (Montrer CA2 Anticorps)+)/NFAT (Montrer NFATC1 Anticorps) signaling as a critical maintenance pathway of the remodeling vasculature
Nkx2-5 (Montrer NKX2-5 Anticorps) has a role in regulating cardiac growth through modulation of Wnt (Montrer WNT2 Anticorps) signaling by R-spondin3
Rspo3 loss of function mutation in combination with Rspo2 (Montrer RSPO2 Anticorps) mutation,but not on its own, causes severe limb truncation.
Sexually dimorphic expression patterns were observed for WNT (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps)-responsive genes, and for Wnt2b (Montrer WNT2B Anticorps), Wnt4 (Montrer WNT4 Anticorps), Wnt7a (Montrer WNT7A Anticorps), Wnt9b (Montrer WNT9B Anticorps), Wnt10b (Montrer WNT10B Anticorps), Wnt11 (Montrer WNT11 Anticorps), Wnt16 (Montrer WNT16 Anticorps), and Rspo3 mRNAs.
Data show that Rspo3 binds syndecan 4 (Montrer SDC4 Anticorps) and that together they activate Wnt5a (Montrer WNT5A Anticorps)/PCP (Montrer BMP1 Anticorps) signaling.
suggest a critical role for Rspo3 in the interaction between chorion and allantois in labyrinthine development
identify Rspo3 as a novel, evolutionarily conserved angiogenic factor (Montrer VEGFA Anticorps) in embryogenesis
This gene encodes a member of the thrombospondin type 1 repeat supergene family. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.
, R-spondin 3 homolog
, protein with TSP type-1 repeat
, roof plate-specific spondin-3
, thrombospondin type-1 domain-containing protein 2
, thrombospondin, type I, domain containing 2
, R-spondin 3-like protein
, cristin 1
, cysteine-rich and single thrombospondin domain-containing protein 1
, thrombospondin, type I, domain 2