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RASSF1 encodes a protein similar to the RAS effector proteins. De plus, nous expédions Ras Association (RalGDS/AF-6) Domain Family Member 1 Anticorps (139) et Ras Association (RalGDS/AF-6) Domain Family Member 1 Protéines (8) et beaucoup plus de produits pour cette protéine.
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Data show that silencing DNA methyltransferase 1 (DNMT1 (Montrer DNMT1 Kits ELISA)) increased expression of tumor suppressor genes, RASSF1A and DAPK (Montrer DAPK1 Kits ELISA), in esophageal squamous cell carcinoma (ESCC) cells and ESCC xenograft in nude mice.
Describe a novel interaction between Rheb and the tumor suppressor RASSF1A. This interaction may allow coordinate upregulation of Hippo while TOR is suppressed to modulate the balance of apoptosis and autophagy in lung tumor cells.
Nine of the 32 (28.1%) iCCA patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 (Montrer RNF2 Kits ELISA) mutations, two each (6.3%) of CACNA2D3 (Montrer CACNA2D3 Kits ELISA) and RASSF1 mutations, and one each (3.1%) of ATG7 (Montrer ATG7 Kits ELISA) and PLCD1 (Montrer PLCD1 Kits ELISA) mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.
Gestational age-dependent increase of hypermethylated RASSF1A; the fetal specific epigenetic marker in maternal plasma was demonstrated, in an Indian study group of normal pregnant women.
the RASSF1 gene polymorphism influences molecular carcinogenesis and clinic pathological features of hepatocellular carcinoma within the Egyptian population
We report for the first time that RASSF1A promoter methylation provides significant prognostic information in high-grade serous ovarian cancer patients.
The main finding of this study was the significant association between RASSF1A promoter methylation and increased EC risk.
Data suggest that the overexpression of DNMT3B4 may play an important role in human kidney tumorigenesis through chromosomal instability and methylation of RASSF1A.
Methylation status of the RASSF1A gene promoter was strongly related to melanoma susceptibility but no significant difference was found between RASSF1A gene promoter methylation and the prognosis and clinical-pathological features of melanoma.
In response to TGF-beta (Montrer TGFB1 Kits ELISA), RASSF1A is recruited to TGF-beta (Montrer TGFB1 Kits ELISA) receptor I and targeted for degradation by the co-recruited E3 ubiquitin ligase ITCH. RASSF1A degradation is necessary to permit Hippo pathway effector YAP1 (Montrer YAP1 Kits ELISA) association with SMADs and subsequent nuclear translocation of receptor-activated SMAD2 (Montrer SMAD2 Kits ELISA).
essential role of RASSF1A in regulating TNF-alpha (Montrer TNF Kits ELISA) signalling in cardiomyocytes, with RASSF1A being key in the formation of the TNFR (Montrer TNFRSF1A Kits ELISA) complex and in signal transmission to the downstream targets
RASSF1A may function to interfere and restrict TLR-driven activation of NF-kappaB (Montrer NFKB1 Kits ELISA) and is essential for protection against inflammation-induced injury.
nickel-smelting fumes upregulated the expression of RASSF1A. This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.
Loss of RASSF1A synergizes with deregulated RUNX2 (Montrer RUNX2 Kits ELISA) signaling in tumorigenesis.
Concomitant with the loss of Rassf1a, the loss of p53 (Montrer TP53 Kits ELISA) (which causes unrestrained propagation of tetraploids into aneuploid cells) further undermines genomic stability and accelerates tumorigenesis.
Data show that methylation of CCND-2 (Montrer CCND2 Kits ELISA), p16, RAR-beta (Montrer RARB Kits ELISA) and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens.
Rassf1A acts as a tumor suppressor gene.
cooperation between inactivation of Rassf1a and Apc (Montrer APC Kits ELISA) resulting in accelerated intestinal tumourigenesis.
RASSF1A mediates p21Cip1/Waf1 (Montrer CDKN1A Kits ELISA)-dependent cell cycle arrest and senescence through modulation of the Raf (Montrer RAF1 Kits ELISA)-MEK (Montrer MDK Kits ELISA)-ERK (Montrer EPHB2 Kits ELISA) pathway and inhibition of Akt (Montrer AKT1 Kits ELISA).
data establish RASSF1A as a novel inhibitor of cardiac hypertrophy by modulating the extracellular regulated kinase 1/2 pathway.
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Ras association (RalGDS/AF-6) domain family 1
, Ras association (RalGDS/AF-6) domain family member 1
, ras association domain-containing protein 1
, Ras association domain family 1
, cardiac-specific ras association domain family 1 protein
, pancreas-specific ras association domain family 1 protein
, tumor suppressor protein RDA32
, 123F protein
, RASSF1A tumor suppressor
, protein 123F2