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Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. De plus, nous expédions Ras-Related GTP Binding B Anticorps (42) et Ras-Related GTP Binding B Protéines (4) et beaucoup plus de produits pour cette protéine.
Data suggest DNM2 (Montrer DNM2 Kits ELISA)/RRAGB- (or DNM2 (Montrer DNM2 Kits ELISA)/RRAGC (Montrer RRAGC Kits ELISA)-)dependent endocytosis of extracellular amino acids (AAs (Montrer FGD1 Kits ELISA)) plays critical role in mTORC1 transport/activation; recruitment of mTORC1 from cytoplasm to lysosome is suppressed by DNM2 (Montrer DNM2 Kits ELISA) inhibition; AA deprivation appears to be main cause of mTORC1 inactivation via DNM2 (Montrer DNM2 Kits ELISA) inhibition. (RHEB (Montrer RHEB Kits ELISA) = Ras homolog enriched in brain (Montrer RHEB Kits ELISA); DNM2 (Montrer DNM2 Kits ELISA) = dynamin II (Montrer DNM2 Kits ELISA); RRAG = Ras-related GTP binding protein (Montrer RAB10 Kits ELISA))
Inhibition of glutaminolysis prevents GTP (Montrer AK3 Kits ELISA) loading of RagB and lysosomal translocation and subsequent activation of mTORC1.
RagA (Montrer RRAGA Kits ELISA) and RagB are key regulators of lysosomal function and cardiac protection.
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified.
Ras-related GTP binding B
, ras-related GTP-binding protein A
, Ras-related GTP binding A
, ras-related GTP-binding protein B
, GTP-binding protein ragB
, rag B