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RRAGC encodes a member of the GTR\\/RAG GTP-binding protein family. De plus, nous expédions Ras-Related GTP Binding C Anticorps (68) et Ras-Related GTP Binding C Protéines (6) et beaucoup plus de produits pour cette protéine.
Full-length RagA (Montrer RRAGA Kits ELISA)(GTP (Montrer AK3 Kits ELISA)):RagC(GDP) dimer binds to regulator to activate mTORC1.
The dynamic response of mTORC1 requires intersubunit communication by the Rag GTPases, providing a rationale for why they exist as a dimer and revealing a distinct mode of control for a GTP-binding protein.
These findings implicate mTORC1 dysregulation through a gain-of-function mutation in RagC as a novel molecular basis for syndromic forms of pediatric heart failure, and expand genotype-phenotype correlation in RASopathy-related syndromes
activating nature of the RRAGC mutations, their existence in the dominant clone and their stability during disease progression support their potential as an excellent candidate for therapeutic targeting
FLCN (Montrer FLCN Kits ELISA) and its binding partners, FNIP1 (Montrer FNIP1 Kits ELISA)/2, are Rag-interacting proteins with GAP activity for RagC/D, but not RagA (Montrer RRAGA Kits ELISA)/B.
The constitutively active RagA (Montrer RRAGA Kits ELISA)-RagC heterodimer blocks the inhibitory effect of alcohol (EtOH).
This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants.
Ras-related GTP binding C
, ras-related GTP-binding protein C
, ras-related gtp-binding protein c
, GTPase-interacting protein 2
, Rag C protein
, rag C
, small GTPase homolog
, small GTPase, homolog