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anti-Regulator of Calcineurin 1 (RCAN1) Anticorps

The protein encoded by RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. De plus, nous expédions Regulator of Calcineurin 1 Protéines (17) et Regulator of Calcineurin 1 Kits (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
RCAN1 1823 Q08554
RCAN1 54720 Q9JHG6
RCAN1 266766 Q6IN33
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Top anti-Regulator of Calcineurin 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 162 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Poulet Lapin Inconjugué WB WB Suggested Anti-RCAN1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human Muscle 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué WB The anti-DSCR1 Pab (ABIN390298) is used in Western blot to detect DSCR1 in endothelial tissue lysate. Endothelial cell lysate transferred to membrane was incubated with primary antibody at a 1:500 dilution in 2 % BSA in TBST at 4 °C overnight. Data courtesy of Dr. Katherine Healey, NWCRF Institute, School of Biological Sciences, University of Wales Bangor. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of Calcipressin-1 Antibody  in 293 cell line lysates (35ug/lane). This demonstrates the RCAN1 antibody detected the RCAN1 protein (arrow). Western blot analysis of RCAN1 (arrow) using Calcipressin-1 Antibody . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the RCAN1 gene. 0.4 mL Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Lapin Inconjugué EIA, WB TOP: The anti-DSCR1 Pab is used in Western blot to detect DSCR1 in endothelial cell lysate. BOTTOM: Endothelial cell lysate transferred to membrane was incubated with primary antibody at a 1:500 dilution in 2% BSA in TBST at 4¢ªC overnight. 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué EIA, WB TOP: The anti-DSCR1 Pab is used in Western blot to detect DSCR1 in endothelial tissue lysate. BOTTOM: Endothelial cell lysate transferred to membrane was incubated with primary antibody at a 1:500 dilution in 2% BSA in TBST at 4¢ªC overnight. 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué WB WB Suggested Anti-RCAN1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Placenta WB Suggested Anti-RCAN1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Human Placenta 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué WB WB Suggested Anti-Rcan1 AntibodyTitration: 1.0 µg/mL  Positive Control: Rat Thymus 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué WB The anti-DSCR1 Pab (ABIN390297) is used in Western blot to detect DSCR1 in endothelial cell lysate. Endothelial cell lysate transferred to membrane was incubated with primary antibody at a 1:500 dilution in 2 % BSA in TBST at 4 °C overnight. Data courtesy of Dr. Katherine Healey, NWCRF Institute, School of Biological Sciences, University of Wales Bangor. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 6 to 8 Days
342,86 €
Détails
Humain Lapin Inconjugué ICC, IF, WB WB Image Sample (30 ug of whole cell lysate) A: Hela 12% SDS PAGE antibody diluted at 1:1000 ICC/IF Image Calcipressin 1 antibody detects Calcipressin 1 protein at cytoplasm and nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Calcipressin 1 protein stained by Calcipressin 1 antibody , diluted at 1:500. Blue: Hoechst 33342 staining. 100 μL Connectez-vous pour afficher 5 to 7 Days
357,24 €
Détails

RCAN1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-Regulator of Calcineurin 1 Anticorps mieux référencés

  1. Human Polyclonal RCAN1 Primary Antibody pour WB - ABIN390298 : Hirakawa, Nary, Medh: Glucocorticoid evoked upregulation of RCAN1-1 in human leukemic CEM cells susceptible to apoptosis. dans Journal of molecular signaling 2009 (PubMed)
    Show all 6 references for ABIN390298

  2. Human Polyclonal RCAN1 Primary Antibody pour EIA, WB - ABIN358860 : Minami, Horiuchi, Miura, Abid, Takabe, Noguchi, Kohro, Ge, Aburatani, Hamakubo, Kodama, Aird: Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. dans The Journal of biological chemistry 2004 (PubMed)
    Show all 3 references for ABIN358860

  3. Chicken Polyclonal RCAN1 Primary Antibody pour WB - ABIN2780590 : Riper, Jayakumar, Latchana, Bhoiwala, Mitchell, Valenti, Crawford: Regulation of vascular function by RCAN1 (ADAPT78). dans Archives of biochemistry and biophysics 2008 (PubMed)
    Show all 2 references for ABIN2780590

  4. Human Polyclonal RCAN1 Primary Antibody pour EIA, WB - ABIN951003 : Tam, van de Lagemaat, Redon, Strathdee, Croning, Malloy, Muir, Pickard, Deary, Blackwood, Carter, Grant: Confirmed rare copy number variants implicate novel genes in schizophrenia. dans Biochemical Society transactions 2010 (PubMed)
    Show all 2 references for ABIN951003

  5. Human Polyclonal RCAN1 Primary Antibody pour ELISA, WB - ABIN1451085 : Fuentes, Pritchard, Estivill: Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. dans Genomics 1997 (PubMed)

  6. Human Polyclonal RCAN1 Primary Antibody pour EIA, WB - ABIN358861 : Yang, Chen, Edgar, Li, Molkentin, Berman, Lin: Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function. dans The Journal of experimental medicine 2009 (PubMed)

Plus d’anticorps contre Regulator of Calcineurin 1 partenaires d’interaction

Xenopus laevis Regulator of Calcineurin 1 (RCAN1) interaction partners

  1. RCAN1-regulated vascular branching which may play a role in the patterning of morphologically different vasculature.

Human Regulator of Calcineurin 1 (RCAN1) interaction partners

  1. The objective of this study was aimed to detect the association of Down syndrome critical region 1 (DSCR1) gene polymorphisms (rs149048873 and rs143081213) and congenital heart disease (CHD (Montrer CHDH Anticorps)) susceptibility.

  2. Results support overexpression of RCAN1 and particularly the RCAN1.1S isoform during aging as a pathogenic mechanism in both Down syndrome-related and sporadic Alzheimer's disease

  3. RCAN1 can interact with IkappaBalpha (Montrer NFKBIA Anticorps) and affect the phosphorylation of IkappaBalpha (Montrer NFKBIA Anticorps) at tyrosine 42.

  4. The sequence variations in RCAN1 promoter are not major genetic factors involved in sporadic CHD (Montrer CHDH Anticorps), at least in the current research population.

  5. E4BP4 (Montrer NFIL3 Anticorps) and BIM (Montrer BCL2L11 Anticorps) regulation correlated with that of RCAN1-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1-1

  6. Rcan1-1L may play a protective role in Ang II (Montrer AGT Anticorps)-treated cardiomyocytes through the induction of mitochondrial autophagy, and may be an alternative method of cardiac protection.

  7. Results show that Rcan1 isoform 1L (Rcan1-1L) overexpression specifically activates mitophagy and increases cell survival under hypoxic conditions.

  8. Data show that after IL-1beta (Montrer IL1B Anticorps) treatment, the levels of reactive oxygen species and interleukin 8 (IL-8 (Montrer IL8 Anticorps)) mRNA of Down syndrome candidate region-1 (DSCR1)-transfected cells treated without BAPTA was significantly lower than those in pcDNA-transfected cells.

  9. Study showed that RCAN1 further contributes to Alzheimer's disease pathogenesis by increasing N-glycosylation and Abeta (Montrer APP Anticorps) production

  10. These results suggest that USP22 (Montrer USP22 Anticorps) positively regulates RCAN1 levels, which would consequently affect diverse RCAN1-linked cellular processes.

Mouse (Murine) Regulator of Calcineurin 1 (RCAN1) interaction partners

  1. These results uncover a critical link between calcineurin (Montrer PPP3CA Anticorps) signalling, impaired neurotrophin (Montrer BDNF Anticorps) trafficking and neurodevelopmental deficits in the peripheral nervous system in Down syndrome.

  2. Data suggest that expression of Dscr1 in hippocampus can be regulated by dietary factors; supplementation of maternal diet and offspring diet with fish oil down-regulates Dscr1 in hippocampus of offspring; Dscr1 is a presumed target in Down syndrome.

  3. inhibition of the calcineurin (Montrer PPP3CA Anticorps)-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo

  4. PACAP (Montrer ADCYAP1 Anticorps) targets RCAN1 to control neuronal differentiation.

  5. We also confirmed that overexpression of RCAN1-1L could inhibit the transcriptional activation of an NFAT (Montrer NFATC1 Anticorps)-dependent promoter in response to PMA and ionomycin by inhibiting Calcineurin (Montrer PPP3CA Anticorps) activity in HEK293T cells

  6. found that RCAN1/3 interact with RAF (Montrer RAF1 Anticorps) kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF (Montrer RAF1 Anticorps) kinases may influence T cell positive selection

  7. Calcineurin (Montrer PPP3CA Anticorps) and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.

  8. Data indicate that neuron from Down syndrome candidate region 1 (DSCR1)-transgenic mice were more resistant than wild-type neurons to apoptotic cell death following 24 h of glucose deprivation.

  9. A major role for haematopoietic Rcan1 in atherosclerosis and suggest that therapies aimed at inhibiting RCAN1 expression or function might significantly reduce atherosclerosis burden.

  10. SCF (Montrer KITLG Anticorps)-mediated activation induced expression of Rcan1 in bone-marrow-derived mast cells. Rcan1 suppresses SCF (Montrer KITLG Anticorps)-induced activation of calcineurin (Montrer PPP3CA Anticorps) & NF-kappaB (Montrer NFKB1 Anticorps), & negatively regulates its own expression via Egr1 (Montrer EGR1 Anticorps).

Regulator of Calcineurin 1 (RCAN1) profil antigène

Profil protéine

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.

Gene names and symbols associated with RCAN1

  • regulator of calcineurin 1 (RCAN1) anticorps
  • regulator of calcineurin 1b (rcan1b) anticorps
  • Down syndrome critical region gene 1 (dscr1) anticorps
  • regulator of calcineurin 1 (rcan1) anticorps
  • desmocollin 1 (DSC1) anticorps
  • DSCR1-like protein (LOC443255) anticorps
  • regulator of calcineurin 1 (Rcan1) anticorps
  • 2410048A02Rik anticorps
  • AA408855 anticorps
  • Adapt78 anticorps
  • AI429645 anticorps
  • AL024459 anticorps
  • AV028423 anticorps
  • CALP1L anticorps
  • CDHF1 anticorps
  • CSP1 anticorps
  • DG2/DG3 anticorps
  • DSC1 anticorps
  • Dscr1 anticorps
  • Mcip1 anticorps
  • MGC53636 anticorps
  • MGC69428 anticorps
  • rcan1 anticorps
  • RCN1 anticorps
  • wu:fr92c05 anticorps

Protein level used designations for RCAN1

regulator of calcineurin 1 , Down syndrome critical region gene 1 , cadherin family member 1 , desmocollin-1 , desmosomal glycoprotein 2/3 , calcipressin-1 , down syndrome critical region protein 1 , Down syndrome candidate region 1 , calcium and oxidant-inducible mRNA , modulatory calcineurin-interacting protein 1 , myocyte-enriched calcineurin-interacting protein 1 , near DSCR proline-rich protein , Down syndrome critical region homolog 1 , calcineurin inhibitor , calcipressin 1 , down syndrome critical region protein 1 homolog , myocyte-enriched calcineurin interactin protein 1 , Down syndrome critical region protein 1 homolog , Oxidative-induced protein Adapt78

GENE ID SPECIES
697108 Macaca mulatta
336348 Danio rerio
380353 Xenopus laevis
448016 Xenopus (Silurana) tropicalis
1823 Homo sapiens
443255 Ovis aries
1827 Homo sapiens
54720 Mus musculus
379550 Xenopus laevis
418510 Gallus gallus
607887 Canis lupus familiaris
539640 Bos taurus
266766 Rattus norvegicus
100171642 Pongo abelii
100689474 Cricetulus griseus
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