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The protein encoded by RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. De plus, nous expédions Regulator of Calcineurin 1 Protéines (17) et Regulator of Calcineurin 1 Kits (7) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal RCAN1 Primary Antibody pour WB - ABIN390298
Hirakawa, Nary, Medh: Glucocorticoid evoked upregulation of RCAN1-1 in human leukemic CEM cells susceptible to apoptosis. dans Journal of molecular signaling 2009
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Human Polyclonal RCAN1 Primary Antibody pour EIA, WB - ABIN358860
Minami, Horiuchi, Miura, Abid, Takabe, Noguchi, Kohro, Ge, Aburatani, Hamakubo, Kodama, Aird: Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. dans The Journal of biological chemistry 2004
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Chicken Polyclonal RCAN1 Primary Antibody pour WB - ABIN2780590
Riper, Jayakumar, Latchana, Bhoiwala, Mitchell, Valenti, Crawford: Regulation of vascular function by RCAN1 (ADAPT78). dans Archives of biochemistry and biophysics 2008
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Human Polyclonal RCAN1 Primary Antibody pour EIA, WB - ABIN951003
Tam, van de Lagemaat, Redon, Strathdee, Croning, Malloy, Muir, Pickard, Deary, Blackwood, Carter, Grant: Confirmed rare copy number variants implicate novel genes in schizophrenia. dans Biochemical Society transactions 2010
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Human Polyclonal RCAN1 Primary Antibody pour ELISA, WB - ABIN1451085
Fuentes, Pritchard, Estivill: Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. dans Genomics 1997
Human Polyclonal RCAN1 Primary Antibody pour EIA, WB - ABIN358861
Yang, Chen, Edgar, Li, Molkentin, Berman, Lin: Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function. dans The Journal of experimental medicine 2009
Mouse (Murine) Polyclonal RCAN1 Primary Antibody pour ELISA, WB - ABIN4349720
Lee, Garvey, Baras, Lemmon, Gomez, Schoppee Bortz, Daum, LeBoeuf, Wamhoff: Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells. dans Human molecular genetics 2009
RCAN1-regulated vascular branching which may play a role in the patterning of morphologically different vasculature.
DSC1 expression is significantly downregulated in human masticatory mucosa during wound healing
Increased expression of DSC1 can promote the occurrence of head and neck squamous cell carcinoma (HNSCC) and is associated with tumor. The increased expression of DSC1 also indicates a poor prognosis of the patients with HNSCC.
The objective of this study was aimed to detect the association of Down syndrome critical region 1 (DSCR1) gene polymorphisms (rs149048873 and rs143081213) and congenital heart disease (CHD (Montrer CHDH Anticorps)) susceptibility.
Results support overexpression of RCAN1 and particularly the RCAN1.1S isoform during aging as a pathogenic mechanism in both Down syndrome-related and sporadic Alzheimer's disease
RCAN1 can interact with IkappaBalpha (Montrer NFKBIA Anticorps) and affect the phosphorylation of IkappaBalpha (Montrer NFKBIA Anticorps) at tyrosine 42.
The sequence variations in RCAN1 promoter are not major genetic factors involved in sporadic CHD (Montrer CHDH Anticorps), at least in the current research population.
E4BP4 (Montrer NFIL3 Anticorps) and BIM (Montrer BCL2L11 Anticorps) regulation correlated with that of RCAN1-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1-1
Rcan1-1L may play a protective role in Ang II (Montrer AGT Anticorps)-treated cardiomyocytes through the induction of mitochondrial autophagy, and may be an alternative method of cardiac protection.
Results show that Rcan1 isoform 1L (Rcan1-1L) overexpression specifically activates mitophagy and increases cell survival under hypoxic conditions.
Data show that after IL-1beta (Montrer IL1B Anticorps) treatment, the levels of reactive oxygen species and interleukin 8 (IL-8 (Montrer IL8 Anticorps)) mRNA of Down syndrome candidate region-1 (DSCR1)-transfected cells treated without BAPTA was significantly lower than those in pcDNA-transfected cells.
These results uncover a critical link between calcineurin (Montrer PPP3CA Anticorps) signalling, impaired neurotrophin (Montrer BDNF Anticorps) trafficking and neurodevelopmental deficits in the peripheral nervous system in Down syndrome.
Data suggest that expression of Dscr1 in hippocampus can be regulated by dietary factors; supplementation of maternal diet and offspring diet with fish oil down-regulates Dscr1 in hippocampus of offspring; Dscr1 is a presumed target in Down syndrome.
inhibition of the calcineurin (Montrer PPP3CA Anticorps)-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo
PACAP (Montrer ADCYAP1 Anticorps) targets RCAN1 to control neuronal differentiation.
We also confirmed that overexpression of RCAN1-1L could inhibit the transcriptional activation of an NFAT (Montrer NFATC1 Anticorps)-dependent promoter in response to PMA and ionomycin by inhibiting Calcineurin (Montrer PPP3CA Anticorps) activity in HEK293T cells
found that RCAN1/3 interact with RAF (Montrer RAF1 Anticorps) kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF (Montrer RAF1 Anticorps) kinases may influence T cell positive selection
Calcineurin (Montrer PPP3CA Anticorps) and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.
Data indicate that neuron from Down syndrome candidate region 1 (DSCR1)-transgenic mice were more resistant than wild-type neurons to apoptotic cell death following 24 h of glucose deprivation.
A major role for haematopoietic Rcan1 in atherosclerosis and suggest that therapies aimed at inhibiting RCAN1 expression or function might significantly reduce atherosclerosis burden.
SCF (Montrer KITLG Anticorps)-mediated activation induced expression of Rcan1 in bone-marrow-derived mast cells. Rcan1 suppresses SCF (Montrer KITLG Anticorps)-induced activation of calcineurin (Montrer PPP3CA Anticorps) & NF-kappaB (Montrer NFKB1 Anticorps), & negatively regulates its own expression via Egr1 (Montrer EGR1 Anticorps).
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
regulator of calcineurin 1
, Down syndrome critical region gene 1
, cadherin family member 1
, desmosomal glycoprotein 2/3
, down syndrome critical region protein 1
, Down syndrome candidate region 1
, calcium and oxidant-inducible mRNA
, modulatory calcineurin-interacting protein 1
, myocyte-enriched calcineurin-interacting protein 1
, near DSCR proline-rich protein
, Down syndrome critical region homolog 1
, calcineurin inhibitor
, calcipressin 1
, down syndrome critical region protein 1 homolog
, myocyte-enriched calcineurin interactin protein 1
, Down syndrome critical region protein 1 homolog
, Oxidative-induced protein Adapt78