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RRAS2 encodes a member of the R-Ras subfamily of Ras-like small GTPases. De plus, nous expédions Related RAS Viral (R-Ras) Oncogene Homolog 2 Anticorps (54) et Related RAS Viral (R-Ras) Oncogene Homolog 2 Protéines (10) et beaucoup plus de produits pour cette protéine.
Equilibrium dissociation constants were determined for the binding of HRAS, KRAS, NRAS and RRAS2 to the RAS binding (RB) domain of binding proteins.
This article is the first study demonstrating expression of TC21 in human skin malignant tumors and suggests that TC21 is more expressed in highly aggressive skin tumors.
Suggest that TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin (Montrer CDH1 Kits ELISA) and N-cadherin (Montrer CDH2 Kits ELISA) in hepatocellular carcinoma and is associated with tumor progression and poor prognosis in HCC (Montrer FAM126A Kits ELISA).
RasGRF GEFs can activate TC21 in all sublocalizations except the Golgi complex. Farnesylated TC21 can be activated by RasGRF1 (Montrer RASGRF1 Kits ELISA) & RasGRF2 (Montrer RASGRF2 Kits ELISA), but geranylgeranylated TC21 is unresponsive to RasGRF2 (Montrer RASGRF2 Kits ELISA).
TGF-beta (Montrer TGFB1 Kits ELISA) and TC21 have roles in tumorigenesis
TC21 directly links antigen receptors to PI(3 (Montrer PI3 Kits ELISA))K-mediated survival pathways.
SIRT6 (Montrer SIRT6 Kits ELISA), a sirtuin (Montrer SIRT1 Kits ELISA) with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.
The RLIP76 (Montrer RALBP1 Kits ELISA)/R-Ras/ARNO (Montrer CYTH2 Kits ELISA) complex localizes to recycling endosomes.RLIP76 is a linker protein (Montrer LAT Kits ELISA) connecting R-Ras to ARNO (Montrer CYTH2 Kits ELISA).
findings reveal R-Ras2 as a critical regulator of TGF-beta (Montrer TGFB1 Kits ELISA) signaling in vivo.
Data indicate that RRas2(-/-) mice show no major alterations in viability, growth rates, cardiovascular parameters, or fertility.
PI3K, but not RalGDS (Montrer RALGDS Kits ELISA), is an important mediator of cell proliferation by TC21.
role of TC21/R-Ras2 activation in the migration of neurofibromin (Montrer NF1 Kits ELISA)-deficient Schwann cells
Data suggest that R-Ras and TC-21 play a role in facilitating branching and growth in early ureteric bud development, whereas H-Ras (Montrer HRAS Kits ELISA) might favor cell migration and elongation of tubules, events that occur later in development.
This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants.
Ras-related protein R-Ras2
, ras-like protein TC21
, ras-related protein R-Ras2
, teratocarcinoma oncogene