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RTKN encodes a scaffold protein that interacts with GTP-bound Rho proteins. De plus, nous expédions Rhotekin Protéines (8) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal Rhotekin Primary Antibody pour WB - ABIN4890447
Pusapati, Eiseler, Rykx, Vandoninck, Derua, Waelkens, Van Lint, von Wichert, Seufferlein: Protein kinase D regulates RhoA activity via rhotekin phosphorylation. dans The Journal of biological chemistry 2012
Let-7a microRNA inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer.
RTKN is upregulated in hepatocellular carcinoma.MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma.
The RTKN protein is associated with lung cancer in clinic samples and exerts anticancer activity in lung adenocarcinoma cells through inhibiting cell cycle progression and the DNA replication machinery.
RTKN could affect the proliferation and metastasis of colon cancer by reducing expression of MCM2 (Montrer MCM2 Anticorps)/3/5, CDK1 (Montrer CDK1 Anticorps)/2 and PCNA (Montrer PCNA Anticorps)
suggest that interaction of S100A4 (Montrer S100A4 Anticorps) and Rhotekin permits S100A4 (Montrer S100A4 Anticorps) to complex with RhoA (Montrer RHOA Anticorps) and switch Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotypea
Protein kinase D (Montrer PRKD1 Anticorps) regulates RhoA (Montrer RHOA Anticorps) activity via phosphorylation rhotekin at Ser (Montrer SIGLEC1 Anticorps)-435.
Rho/RTKN-mediated NF-kappaB (Montrer NFKB1 Anticorps) activation leading to cell survival may play a key role in gastric tumorigenesis.
These results suggest that the RTKN gene is involved in bladder carcinogenesis and progression in bladder carcinoma, indicating that RTKN gene could be a molecular target in cancer therapy.
Lin-7B (Montrer LIN7B Anticorps) is a binding partner for Rhotekin in the human brain cDNA library
SEPT9 (Montrer SEPT9 Anticorps) sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4 (Montrer SEPT4 Anticorps)/SEPT11 (Montrer SEPT11 Anticorps) and resistance to Rho/Rhotekin-signaling
these findings suggest that cGK (Montrer PRKG1 Anticorps)-Ialpha interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation.
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.