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RNF125 encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. De plus, nous expédions RNF125 Protéines (4) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal RNF125 Primary Antibody pour ICC, IF - ABIN4350731
Kim, Frederick, Levesque, Cooper, Feng, Krepler, Brill, Samuels, Hayward, Perlina, Piris, Zhang, Halaban, Herlyn, Brown, Wargo, Dummer, Flaherty, Ronai: Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation. dans Cell reports 2015
study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 (Montrer TRIM14 Anticorps) in the innate antiviral immune response
Data indicate that brain from Japanese encephalitis virus (JEV)-infection showed a (Montrer UTS2R Anticorps)reciprocal correlation between microRNA miR-15b levels and the ex (Montrer MLXIP Anticorps)pression of ring finger protein 125 (RNF125).
RNF125 is enhanced by IFN, these functions constitute a negative regulatory loop circuit for IFN production
we identified the downregulation of the ubiquitin ligase RNF125 in BRAFi-resistant melanomas
Results indicate that the nucleotide sequence in the 3' untranslated region (3' UTR (Montrer UTS2R Anticorps)) of ring finger protein 125 (RNF125) is a potential microRNA miR (Montrer MLXIP Anticorps)-15b targeting site.
studies of the RNF125 pathway point to upregulation of RIG-I (Montrer DDX58 Anticorps)-IPS1 (Montrer MAVS Anticorps)-MDA5 (Montrer IFIH1 Anticorps) and/or disruption of the PI3K (Montrer PIK3CA Anticorps)-AKT (Montrer AKT1 Anticorps) and interferon (Montrer IFNA Anticorps) signaling pathways as the putative final effectors
In controls, RNF125 is the highest expressed gene, whereas in HIV infection progressors, RIG-I (Montrer DDX58 Anticorps) is either the highest expressed gene or is expressed similarly to RNF125 and TRIM25 (Montrer TRIM25 Anticorps).
study reports human bocavirus VP2 modulates IFN pathway by targeting the ring finger protein 125, a negative regulator of type I IFN signaling, which conjugates Lys (Montrer LYZ Anticorps)(48)-linked ubiquitination to retinoic acid-inducible gene-I (Montrer DDX58 Anticorps) and leads to the proteasome-dependent degradation of RIG-I (Montrer DDX58 Anticorps)
These results suggest that RNF125/TRAC-1 could function to recruit host factor(s) controlling HIV-1 transcription to the ubiquitin-proteasome pathway.
TRAC-1 associates with membranes and is excluded from the nucleus through myristoylation
This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.
E3 ubiquitin-protein ligase RNF125
, T-cell RING activation protein 1
, T-cell ring protein identified in activation screen