Ring Finger and WD Repeat Domain 3 Protéines (RFWD3)

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. De plus, nous expédions RFWD3 Anticorps (29) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat RFWD3 RFWD3 361409  
RFWD3 55159 Q6PCD5
RFWD3 234736 Q8CIK8
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Top RFWD3 Protéines sur anticorps-enligne.fr

Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$11,073.30
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$11,073.30
Détails
HOST_Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$405.71
Détails

RFWD3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Ring Finger and WD Repeat Domain 3 (RFWD3) partenaires d'interaction

Horse (Equine) Ring Finger and WD Repeat Domain 3 (RFWD3) interaction partners

  1. a polymorphism in the 3'-UTR of RFWD3 had a strong association with PATN1, which affects spotting patterns in horse coat color

Human Ring Finger and WD Repeat Domain 3 (RFWD3) interaction partners

  1. The results suggest that RPA phosphorylation enhances the recruitment of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a process requiring both PRP19 and RFWD3, thereby triggering a phosphorylation-ubiquitylation circuitry that promotes ATR activation and homologous recombination.

  2. Single point mutations in the RPA32 subunit of RPA that abolish interaction with RFWD3 also inhibit interstrand crossling repair, demonstrating that RPA-mediated RFWD3 recruitment to stalled replication forks is important for ICL repair.

  3. E3 ligase RFWD3 functions in timely removal and degradation of RPA (Montrer RPA1 Protéines) and RAD51 (Montrer RAD51 Protéines) to allow homologous recombination progression to subsequent steps following mitomycin C damage.

  4. RFWD3-dependent ubiquitination of RPA regulates repair at stalled replication forks.

  5. RFWD3 and RPA2 (Montrer RPA2 Protéines) functionally interact and participate in replication checkpoint control

  6. RFWD3 is recruited to sites of DNA damage and facilitates RPA-mediated DNA damage signaling and repair

  7. Study identifies RFWD3 as a positive regulator of p53 (Montrer TP53 Protéines) stability when the G(1) cell cycle checkpoint is activated and provides an explanation for how p53 (Montrer TP53 Protéines) is protected from degradation in the presence of high levels of Mdm2 (Montrer MDM2 Protéines).

Profil protéine RFWD3

Profil protéine

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.

Gene names and symbols associated with RFWD3

  • ring finger and WD repeat domain 3 (Rfwd3)
  • ring finger and WD repeat domain 3 (RFWD3)
  • BC027246 Protéine
  • RFWD3 Protéine
  • RGD1305243 Protéine
  • RNF201 Protéine

Protein level used designations for RFWD3

ring finger and WD repeat domain 3 , RING finger and WD repeat domain-containing protein 3-like , E3 ubiquitin-protein ligase RFWD3 , RING finger and WD repeat domain-containing protein 3 , RING finger protein 201

GENE ID SPECIES
361409 Rattus norvegicus
415684 Gallus gallus
454242 Pan troglodytes
540072 Bos taurus
610424 Canis lupus familiaris
100055114 Equus caballus
100229473 Taeniopygia guttata
100387225 Callithrix jacchus
100461058 Pongo abelii
55159 Homo sapiens
234736 Mus musculus
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