Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Kits ELISA

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. De plus, nous expédions RUNX1T1 Anticorps (39) et RUNX1T1 Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
Anti-Rat RUNX1T1 RUNX1T1 362489  
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Plus Kits ELISA pour RUNX1T1 partenaires d'interaction

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  2. Leukaemogenesis by AML1 (Montrer RUNX1 Kits ELISA)-ETO requires enhanced C/D box snoRNA/RNP (Montrer RNPC3 Kits ELISA) formation.

  3. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (Montrer RUNX1 Kits ELISA)-175) of AML1 (Montrer RUNX1 Kits ELISA)-ETO is consistent with its contribution to the activity of full-length AML1 (Montrer RUNX1 Kits ELISA)-ETO and is mediated through its direct association with the DNA-binding domain

  4. the AML1 (Montrer RUNX1 Kits ELISA)-ETO fusion protein increases the expression of SIRT1 (Montrer SIRT1 Kits ELISA), possibly by binding to the promoter region of SIRT1 (Montrer SIRT1 Kits ELISA) to activate its transcription in t(8;21) AML (Montrer RUNX1 Kits ELISA).

  5. A feedback circuitry involving miR (Montrer MLXIP Kits ELISA)-9-1 and RUNX1 (Montrer RUNX1 Kits ELISA)-RUNX1T1.

  6. The role of RUNX1T1 in t(8;21) acute myeloid leukemia (Montrer BCL11A Kits ELISA) and miRNA expression regulation

  7. Our data revealed a novel role for RUNX1T1 as a tumor-suppressor gene in colorectal cancer through modulation of multiple cellular pathways affecting the cell cycle, DNA damage, DNA replication, estrogen signaling, and drug resistance

  8. Exon splicing patterns in the human RUNX1 (Montrer RUNX1 Kits ELISA)-RUNX1T1 fusion gene present in acute myeloid leukemia (Montrer BCL11A Kits ELISA) patients have been decoded.

  9. Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1 (Montrer RUNX1 Kits ELISA)-ETO/RUNX1 (Montrer RUNX1 Kits ELISA)-RUNX1T1 is facilitated by interaction with the chaperonin (Montrer HSPD1 Kits ELISA) TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70 (Montrer HSP70 Kits ELISA)).

  10. AML1/ETO transactivates gene expression through recruiting AP-1 to the AML1/ETO-AML1 complex.

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  2. Leukaemogenesis by AML1 (Montrer RUNX1 Kits ELISA)-ETO requires enhanced C/D box snoRNA/RNP (Montrer RNPC3 Kits ELISA) formation.

  3. Data show that RUNX1 (Montrer RUNX1 Kits ELISA)-ETO;c-Kit (Montrer KIT Kits ELISA)(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (Montrer BCL11A Kits ELISA) (AML (Montrer RUNX1 Kits ELISA)) in a fraction (51%) of reconstituted mice.

  4. Self-renewal induced by AML1 (Montrer RUNX1 Kits ELISA)/ETO in primary murine progenitors was inhibited when Aes (Montrer AES Kits ELISA) was decreased or absent.

  5. AML1 (Montrer RUNX1 Kits ELISA)-ETO synergizes with an ICSBP (Montrer IRF8 Kits ELISA) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  6. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (Montrer CEBPB Kits ELISA) and a novel regulator of early adipogenesis

  7. the loss of the molecular events of AML1 (Montrer RUNX1 Kits ELISA)-ETO C-terminal NCoR (Montrer NCOR1 Kits ELISA)/SMRT-interacting domain transforms AML1 (Montrer RUNX1 Kits ELISA)-ETO into a potent leukemogenic protein

  8. p15(Ink4b (Montrer CDKN2B Kits ELISA)) loss must be accompanied by additional oncogenic changes for RUNX1 (Montrer RUNX1 Kits ELISA)-ETO-associated AML (Montrer RUNX1 Kits ELISA) to develop

  9. AML1 DNA-binding domain and the ETO NHR2-dimerization domain, but not the ETO NHR1 domain, are critical for the induction of acute myeloid leukemia by AML1-ETO9a

  10. the eTAFH-E protein interaction appears to contribute relatively little to the activity of AML1 (Montrer RUNX1 Kits ELISA)-ETO

RUNX1T1 profil antigène

Antigen Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1) anticorps
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1) anticorps
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1) anticorps
  • AML1T1 anticorps
  • Cbfa2t1 anticorps
  • Cbfa2t1h anticorps
  • CDR anticorps
  • ETO anticorps
  • MTG8 anticorps
  • si:ch211-232j17.1 anticorps
  • wu:fi14b07 anticorps
  • zgc:154044 anticorps
  • ZMYND2 anticorps

Protein level used designations for RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPECIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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