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a component of amyloid P. De plus, nous expédions et SH2 Domain Protein 1A Anticorps (6) et beaucoup plus de produits pour cette protéine.
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Human SH2D1A Kit ELISA pour Sandwich ELISA - ABIN414747
Oberbach, Blüher, Wirth, Till, Kovacs, Kullnick, Schlichting, Tomm, Rolle-Kampczyk, Murugaiyan, Binder, Dietrich, von Bergen: Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes. dans Journal of proteome research 2011
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High LAT1 expression correlated with significantly shorter prostate specific antigen recurrence-free survival in patients receiving androgen deprivation therapy
We describe here a novel c.137+5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM (Montrer SLAMF1 Kits ELISA))-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM (Montrer ZMYM2 Kits ELISA)) in an 8-year-old male patient and his 3-year-old step brother. The mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant.
In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.
The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation
Study of SAP (Montrer APCS Kits ELISA) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (Montrer CD244 Kits ELISA) functional assay allows identification of all cases
Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (Montrer APCS Kits ELISA) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (Montrer SLAMF1 Kits ELISA) peptide.
Signaling lymphocytic activation molecule (SLAM)/SLAM (Montrer SLAMF1 Kits ELISA)-associated protein pathway regulates human B-cell tolerance.
In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (Montrer APCS Kits ELISA) is nonfunctional, not only abolishing the activating function of 2B4 (Montrer CD244 Kits ELISA), but rendering this receptor inhibitory.
our data reveal how SAP (Montrer APCS Kits ELISA) nucleates a previously unknown signaling complex involving NTB-A (Montrer SLAMF6 Kits ELISA) and LCK (Montrer LCK Kits ELISA) to potentiate restimulation-induced cell death of activated human T cells.
SAP (Montrer APCS Kits ELISA) is a new actor downstream of PECAM-1 (Montrer PECAM1 Kits ELISA) and its binding regulates PECAM-1 (Montrer PECAM1 Kits ELISA) mediated cell adhesion.
SAP (Montrer APCS Kits ELISA) is an essential molecule for autoimmune antibody production.
SLAM (Montrer SLAMF1 Kits ELISA)-SAP (Montrer APCS Kits ELISA) signaling promotes differentiation of IL-17 (Montrer IL17A Kits ELISA)-producing T cells and progression of experimental autoimmune encephalomyelitis.
these data suggest that SAP (Montrer APCS Kits ELISA) is critical for regulating type II NKT (Montrer CTSL1 Kits ELISA) cell responses.
functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability
Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (Montrer APCS Kits ELISA)-/- mice and in Rag-/- mice into which B cells derived from SAP (Montrer APCS Kits ELISA)-/- mice together with wt CD4 (Montrer CD4 Kits ELISA)+ T cells had been transferred.
SAP (Montrer APCS Kits ELISA) plays an essential role in CIA (Montrer NCOA5 Kits ELISA) because of Fyn (Montrer FYN Kits ELISA)-independent and Fyn (Montrer FYN Kits ELISA)-dependent effects on TFH cells and, possibly, other T cell types.
SAP (Montrer APCS Kits ELISA) was required not only for the initiation but also for the progression of primary T cell-driven B cell responses to haptens.
Loss of SAP (Montrer APCS Kits ELISA) expression is associated with invariant NKT (Montrer CTSL1 Kits ELISA) cell cytotoxicity and defective lytic synapse formation.
SAP (Montrer APCS Kits ELISA) is required for the development of innate phenotype in H2-M3--restricted Cd8 (Montrer CD8A Kits ELISA)(+) T cells.
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
serum amyloid P-component
, Duncan disease SH2-protein
, SH2 domain-containing protein 1A
, SLAM associated protein/SH2 domain protein 1A
, SLAM-associated protein
, T cell signal transduction molecule SAP
, T-cell signal transduction molecule SAP
, signaling lymphocyte activation molecule-associated protein
, signaling lymphocytic activation molecule-associated protein
, SH2 domain protein 1A
, Duncan disease homolog