Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
The protein encoded by SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. De plus, nous expédions SMAD5 Protéines (14) et SMAD5 Kits (8) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 111 products:
Human Polyclonal SMAD5 Primary Antibody pour WB - ABIN1881816
Park, Lee, Ahn, Kim: Predicting the multi-modal binding propensity of small molecules: towards an understanding of drug promiscuity. dans Molecular bioSystems 2009
Show all 5 Pubmed References
Human Monoclonal SMAD5 Primary Antibody pour ICC, FACS - ABIN969404
Chang, Chang, Lee, Lee, Yeh, Yeh, Cheng, Chien, Chiu: Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad. dans Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 2 Pubmed References
TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway.
Alk3 and Alk3b, as well as SMAD5, are essential cellular mediators of BMP signaling in zebrfish.
Data show that interplay of Smad1 (Montrer SMAD1 Anticorps)/5 and MAP kinase (Montrer MAPK1 Anticorps) signaling system (ERK (Montrer MAPK1 Anticorps) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.
this study uncovers that smad1 (Montrer SMAD1 Anticorps) and smad9 (Montrer SMAD9 Anticorps) act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis.
Functional investigation of a subset of these genes, fgf10a (Montrer FGF10 Anticorps), tgfb2 (Montrer TGFB2 Anticorps), pax9 (Montrer PAX9 Anticorps), and smad5 revealed their necessity in zebrafish palatogenesis.
maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2 (Montrer BMP4 Anticorps)/7 signaling to establish the initial dorsoventral asymmetry
Data show that patterning of the eye primordia in Smad5-deficient embryos starts during blastula and early gastrula stages.
that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 (Montrer SMAD1 Anticorps) and Smad5.
Data show that Smad5 expression is ubiquitous during testis development but becomes cell-specific in the adult.
the BMP-2 (Montrer BMP2 Anticorps)/Smad1 (Montrer GARS Anticorps)/5/RUNX2 (Montrer RUNX2 Anticorps) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (Montrer BGLAP Anticorps) synth
miR (Montrer MLXIP Anticorps)-23a and miR (Montrer MLXIP Anticorps)-27a target SMAD5 and regulate apoptosis in human granulosa cells via the FasL (Montrer FASL Anticorps)-Fas (Montrer FAS Anticorps) pathway
Our findings suggest that suppression of miR (Montrer MLXIP Anticorps)-222-3p activity promoted osteogenic differentiation hBMSCs through regulating Smad5-RUNX2 (Montrer RUNX2 Anticorps) signaling axis.
Overexpression of the BMP4 (Montrer BMP4 Anticorps)/SMAD4 (Montrer SMAD4 Anticorps)/SMAD5 signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis.
The polycomb group protein L3MBTL1 (Montrer L3MBTL1 Anticorps) represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.
adult human Sertoli cells assumed similar morphological features, stable global gene expression profiles and numerous proteins, and activation of AKT (Montrer AKT1 Anticorps) and SMAD1 (Montrer GARS Anticorps)/5 during long-period culture.
balance between Smad1 (Montrer GARS Anticorps)/5- and Smad2 (Montrer SMAD2 Anticorps)/3-dependent signaling defines the outcome of the effect of TGF-beta (Montrer TGFB1 Anticorps) on atherosclerosis where Smad1 (Montrer GARS Anticorps)/5 is responsible for proatherogenic effects
among the 15 SNPs, rs3206634 was significantly associated with KD in a recessive model (odds ratio = 2.31, p = 0.019), whereas there was no association between any of the 15 SNPs and CALs (Montrer CA8 Anticorps).
Our results indicated that KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4 (Montrer SMAD4 Anticorps)/smad5 pathway.
Inhibiting Smurf1 (Montrer SMURF1 Anticorps) mediated ubiquitination of Smad1 (Montrer GARS Anticorps)/5.
We discovered that Smad1 (Montrer SMAD1 Anticorps)/5/4-Amhr2 (Montrer AMHR2 Anticorps)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1 (Montrer SMAD1 Anticorps)/5/4-Amhr2 (Montrer AMHR2 Anticorps)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.
these studies characterize an accessory TGF-beta (Montrer TGFB1 Anticorps)-stimulated BMP R-Smad (Montrer SMAD1 Anticorps) signaling mechanism in interstitial cells of the developing lung.
Thyroid-specific Smad1 (Montrer SMAD1 Anticorps) and Smad5 double-knockout (Smad1 (Montrer SMAD1 Anticorps)/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.
Smad1 (Montrer SMAD1 Anticorps) and Smad5 have overlapping functions to govern hepcidin (Montrer HAMP Anticorps) transcription. Moreover, erythropoietin (Montrer EPO Anticorps) and erythroferrone target Smad1 (Montrer SMAD1 Anticorps)/5 signaling and require Smad1 (Montrer SMAD1 Anticorps)/5 to suppress hepcidin (Montrer HAMP Anticorps) expression.
miR (Montrer MLXIP Anticorps)-106b-5p and miR-17-5p are novel Smad5 regulators.
BetA can enhance in vivo osteogenic potentials of BMP2 (Montrer BMP2 Anticorps), possibly via stimulating Smad 1 (Montrer SMAD1 Anticorps)/5/8 and p38 (Montrer CRK Anticorps) pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases.
Data show that in R-Smad (Montrer SMAD1 Anticorps) proteins Smad1 (Montrer SMAD1 Anticorps);Smad5 knockout embryonic stem cells (mESCs), the bone morphogenetic proteins (BMP)-SMAD (Montrer SMAD1 Anticorps) signaling is dispensable for self-renewal.
Data show that R-Smad Proteins SMAD1 and SMAD5, which transduce bone morphogenetic protein (BMP) signals, recognize enhancer regions together with Kruppel-like factors KLF4 and KLF5 in naive embryonic stem cell (mESCs).
The crystal structure of Smad5-MH1 (Montrer SCN5A Anticorps) domain in complex with a composite DNA sequence demonstrates that the MH1 (Montrer SCN5A Anticorps) domain is targeted to a binding site with modular binding modes, and the length of the DNA spacer affects the MH1 (Montrer SCN5A Anticorps) assembly.
The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2 (Montrer BMP2 Anticorps)/Smad1 (Montrer SMAD1 Anticorps)/5/8 and Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) pathways.
a detailed computational model for TGF-beta (Montrer TGFB1 Anticorps) signalling that incorporates elements of previous models together with crosstalking between Smad1 (Montrer SMAD1 Anticorps)/5/8 and Smad2 (Montrer SMAD2 Anticorps)/3 channels through a negative feedback loop dependent on Smad7 (Montrer SMAD7 Anticorps).
The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.
mothers against decapentaplegic homolog 5
, SMA- and MAD-related protein 5
, SMAD 5
, SMAD family member 5
, mothers against DPP homolog 5
, MAD, mothers against decapentaplegic homolog 5
, SMAD, mothers against DPP homolog 5
, mothers against decapentaplegic, drosophila, homolog of, 5
, MAD homolog 5
, Smad 5
, Mothers against decapentaplegic homolog 5