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SENP8 encodes a cysteine protease that is a member of the sentrin-specific protease family. De plus, nous expédions SUMO/sentrin Specific Peptidase Family Member 8 Anticorps (64) et SUMO/sentrin Specific Peptidase Family Member 8 Protéines (18) et beaucoup plus de produits pour cette protéine.
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mutants of a DEN1 homolog from Arabidopsis thaliana have no detectable defects in NEDD8 processing but do accumulate a broad range of NEDD8 conjugates. Neddylation may serve as a regulatory mechanism for cullin and non-cullin proteins. [DEN1]
In endothelial dysfunction, HDAC2 (Montrer HDAC2 Kits ELISA) levels were reciprocally regulated by ectopic expression of NEDD8 (Montrer NEDD8 Kits ELISA) and the de-NEDDylating enzyme SENP8.
the expression of SENP8, SAE1 (Montrer SAE1 Kits ELISA), PIAS1 (Montrer PIAS1 Kits ELISA), PIAS2 (Montrer PIAS2 Kits ELISA) and ZMIZ1 (Montrer ZMIZ1 Kits ELISA) is deregulated in the majority of PTC (Montrer F9 Kits ELISA) tissues, likely contributing to the PTC (Montrer F9 Kits ELISA) phenotype.
Data indicate that overexpression of SENP8, a NEDD8 (Montrer NEDD8 Kits ELISA)-specific cysteine protease (Montrer CTSB Kits ELISA), resulted in deNEDDylation of E2F1 (Montrer E2F1 Kits ELISA) and promoted its transactivation activity at the p73 (Montrer TP73 Kits ELISA) gene.
We analyzed whether CSN1 (Montrer CSN1S1 Kits ELISA) alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 (Montrer COPS8 Kits ELISA) signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells.
A role for SENP8 as a central regulator of the inflammatory process is identified using knockdown and overexpression approaches.
the specificity of NEDD8 (Montrer NEDD8 Kits ELISA)-specific peptidase SENP8
Data show that the stability of MDM2 (Montrer MDM2 Kits ELISA) is regulated by NEDD8 (Montrer NEDD8 Kits ELISA) pathway and identify NEDP1 that deneddylates MDM2 (Montrer MDM2 Kits ELISA), resulting in MDM2 (Montrer MDM2 Kits ELISA) destabilization concomitant with p53 (Montrer TP53 Kits ELISA) activation.
NEDP1 is likely to play an important role in ubiquitin-mediated proteolysis by controlling the activity of SCF (Montrer KITLG Kits ELISA) complexes
results suggest a unique role for NEDD8-specific protease 1(DEN1) in regulating the modification of cullin 1 (Montrer CUL1 Kits ELISA) by Nedd8 (Montrer NEDD8 Kits ELISA) protein
X-ray structures of the human Nedd8-specific protease (Montrer USP21 Kits ELISA), Den1, in a complex with the inhibitor Nedd8 (Montrer NEDD8 Kits ELISA) aldehyde, thus revealing a model for the tetrahedral transition state intermediate generated during proteolysis
This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.
SUMO/sentrin specific peptidase family member 8
, NEDD8-specific protease 1
, SUMO/sentrin specific protease 8
, SUMO/sentrin specific protease family member 8
, protease, cysteine, 2 (NEDD8 specific)
, sentrin-specific protease 8
, sentrin/SUMO-specific protease SENP8
, NEDD8 specific-protease cysteine 2
, SUMO sentrin specific protease family member 8
, deneddylase 1
, protease, cysteine 2
, SUMO/sentrin specific peptidase 8
, Sumo1/sentrin/SMT3 specific peptidase 8