Signal Peptide Peptidase-Like 2B (SPPL2B) Kits ELISA

SPPL2B encodes a member of the GXGD family of aspartic proteases. De plus, nous expédions SPPL2B Anticorps (9) et SPPL2B Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Humain SPPL2B SPPL2B 56928 Q8TCT7
Anti-Souris SPPL2B SPPL2B 73218 Q3TD49
Anti-Rat SPPL2B SPPL2B 362828 Q5PQL3
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Plus Kits ELISA pour SPPL2B partenaires d'interaction

Zebrafish Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.

Human Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. TfR1 (Montrer TFRC Kits ELISA) N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b.

  2. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2 (Montrer ITM2B Kits ELISA)) determines its processing by signal peptide peptidase-like 2b (SPPL2b).

  3. SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  4. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.

  5. Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha (Montrer TNF Kits ELISA) into the cytosol.

  6. SPPL2a and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 (Montrer ITM2B Kits ELISA) N-terminal fragment.

  7. Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha (Montrer TNF Kits ELISA) and caused a relative increase of longer intracellular cleavage products.

Mouse (Murine) Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. in vivo SPPL2a, but not SPPL2b, exhibit a physiologically relevant contribution to CD74 (Montrer CD74 Kits ELISA) proteolysis in B and dendritic cells

SPPL2B profil antigène

Antigen Summary

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPPL2B

  • signal peptide peptidase-like 2 (sppl2) anticorps
  • signal peptide peptidase-like 2B (sppl2b) anticorps
  • signal peptide peptidase like 2B (sppl2b) anticorps
  • signal peptide peptidase like 2B (SPPL2B) anticorps
  • signal peptide peptidase like 2B (Sppl2b) anticorps
  • signal peptide peptidase-like 2B (SPPL2B) anticorps
  • signal peptide peptidase-like 2B (Sppl2b) anticorps
  • 3110056O03Rik anticorps
  • AW550292 anticorps
  • IMP-4 anticorps
  • IMP4 anticorps
  • MGC147524 anticorps
  • PSH4 anticorps
  • PSL1 anticorps
  • RGD1308556 anticorps
  • SPPL2B anticorps
  • wu:fc16e01 anticorps
  • wu:fc85d12 anticorps
  • zgc:136525 anticorps

Protein level used designations for SPPL2B

signal peptide peptidase-like 2B , signal peptide peptidase-like protein 2 , SPP-like 2B , protein SPP-like 2B , protein SPPL2b , intramembrane protease 4 , presenilin homologous protein 4 , presenilin-like protein 1

GENE ID SPECIES
325540 Danio rerio
780336 Xenopus (Silurana) tropicalis
379574 Xenopus laevis
420056 Gallus gallus
56928 Homo sapiens
73218 Mus musculus
504285 Bos taurus
362828 Rattus norvegicus
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