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SLC47A2 encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. De plus, nous expédions Solute Carrier Family 47, Member 2 Anticorps (44) et et beaucoup plus de produits pour cette protéine.
Pazopanib inhibits OCT2, MATE1 (Montrer SLC47A1 Kits ELISA) and MATE2-K, which are involved in cisplatin secretion into urine, potentiating cisplatin toxicity.
Network and cell biological analysis additionally showed that expression of MATE2-K is regulated by Nrf2 (Montrer GABPA Kits ELISA) signaling
There were statistically significant association between resistance to metformin and MATE2 expression in cancer cells.
These were associated with markedly reduced or increased MATE2-K function.
The results confirmed that OAT1 (Montrer KCNK3 Kits ELISA), OAT3 (Montrer SLC22A8 Kits ELISA), OCT2, MATE1 (Montrer SLC47A1 Kits ELISA), and MATE2-K were coexpressed in tubular epithelial cells.
The effect of novel promoter variants in ... MATE2 on the pharmacokinetics and pharmacodynamics of metformin
MATE2, which facilitates extrusion of drugs and metabolites from blood into urine, is physically or functionally associated with cilia.
4',6-diamidino-2-phenylindole (DAPI) can be used as a probe substrate for rapid assays of the functionality of the human MATE2
characterization of MATE2-K: kinetic analysis of transport of cimetidine and tetraethylammonium; inhibitors; comparison to hMATE1 and rMATE1
These findings suggested that the loss of transport activities of the MATE1 (Montrer SLC47A1 Kits ELISA) G64D and MATE2-K G211V variants were due to the alteration of protein expression in cell surface membranes.
MATE2 mRNA expression levels were the highest in the testis, where high expression was localized to Sertoli cells, a critical cell type of the blood testis barrier.
testes-specific multidrug and toxic compound extrusion 2 (MATE2) act as a polyspecific H(+)/organic cation exporter in Leydig cells.
This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
multidrug and toxin extrusion protein 2
, solute carrier family 47, member 2
, solute carrier family 47 member 2
, H+/organic cation antiporter
, kidney-specific H(+)/organic cation antiporter
, multidrug and toxin extrusion 2
, h(+)/organic cation antiporter kidney-specific